Psycho-Babble Medication Thread 383919

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Zyprexa attributes

Posted by ace on August 29, 2004, at 22:55:33

As per requested by my brother and intellectual heavyweight, Chemist, here is a thread on Zyprexa, for which i will state what I know about it and personal experiences....

Pros/uses
1. Psychotic illness- usual starting dose is 10mg, titrating to 20-30mg. Zyprexa has been shown to unequivocally benifit psychotic patients...those with overvalued ideas (not quite psychotic, but somewhat close to it) can gain relief from as little as 2.5mg.

2. OCD- In my experience and from what I have read Zyprexa is an excellant augmenter for OCD- especially if their is some mild psychotic element to it.

3. Hypnotic- For many, but not me, Zyprexa provides a very strong hypnotic/sedative effect.

4. I believe it is cardiovascularly safe, no lipid abnormalities reported (to my knowledge) and EPS potential, including TD, seems to be EXTREMELY low. Out of probably 170 anecdotes, I have read 1 or 2 people developing mild TD (which abated)

5. Depression- for many, especially in conjuction with a standard antidepressant, Zyprexa exerts an unequivocal AD effect...usual dosage 2.5-10mg.

6. Anxiety- also has anxiolytic properties.

7. Can curb racing thoughts and agitation very quickly.


CONS


1. Withdrawal- quite a few have strong insomnia on withdrawal, which necissitates short term benzo usage or a sedative AD. Some don't- I never have. In fact, I have NO w/drawal sx from Zyprexa.

There you go, I'm sure I missed a lot, so tell me if you disagree or could add something!

Ace

 

thank you, ace!!! (nm) » ace

Posted by chemist on August 30, 2004, at 20:33:04

In reply to Zyprexa attributes, posted by ace on August 29, 2004, at 22:55:33

 

Re: Zyprexa attributes

Posted by gardenergirl on August 30, 2004, at 21:41:43

In reply to Zyprexa attributes, posted by ace on August 29, 2004, at 22:55:33

Isn't Zyprexa also known for weight gain and increased risk of developing type II diabetes?

gg

 

Re: Zyprexa attributes » gardenergirl

Posted by chemist on August 30, 2004, at 21:57:50

In reply to Re: Zyprexa attributes, posted by gardenergirl on August 30, 2004, at 21:41:43

> Isn't Zyprexa also known for weight gain and increased risk of developing type II diabetes?
>
> gg


hi gg...the white-paper indicates weight gain, and i have one m.s. (not a great one, and funded by ortho-mcneil: C. B. Nemeroff, J. Clin. Psychiatry 64:5 pp. 532-539, May 2003) on my desk that states that mean weight gain for olanzapine (zyprexa) from a meta-analysis of 81 journal articles is 9.22 lb. (4.15 kg) and that ``evidence is mounting that antipsychotic treatment may impair glucose tolerance'' and that the drugs implicated are chlorpromazine, clozapine, and olanzapine. i do recall there being a flurry of diabetes mellitus risk, but do not have the refs on hand or in mind. be glad to track 'em down, if you'd like, to confirm/deny.....all the best, chemist

 

Re: Zyprexa attributes » gardenergirl

Posted by ace on August 30, 2004, at 22:00:17

In reply to Re: Zyprexa attributes, posted by gardenergirl on August 30, 2004, at 21:41:43

> Isn't Zyprexa also known for weight gain

Yes.

and increased risk of developing type II diabetes?

This is overrated in my opinion. Before there is a chance you have to have a genetic predisposition for it...

> gg

 

Re: Zyprexa attributes » chemist

Posted by gardenergirl on August 30, 2004, at 22:31:56

In reply to Re: Zyprexa attributes » gardenergirl, posted by chemist on August 30, 2004, at 21:57:50

nah, I think I've run across them on Medscape...but thanks.

gg

 

Re: Zyprexa attributes » gardenergirl » ace

Posted by gardenergirl on August 30, 2004, at 22:37:55

In reply to Re: Zyprexa attributes » gardenergirl, posted by ace on August 30, 2004, at 22:00:17

True...predispositions s*ck!

Warmly,
gg


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