Psycho-Babble Medication Thread 358246

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Xyrem, Amisulpride, Selegiline, Adderall...

Posted by Michael Bell on June 20, 2004, at 6:02:38

Right now I'm taking a combo of Amisulpride and Memantine, and occasionally Klonopin & Adderall for SP. I also throw in some Picamilon and Gamalate every now and then. The combo is good for the anxiety part, but inconsistent as far as any prosocial effect. Even the adderall is sometimes prosocial, and sometimes *lessens* sociability, for whatever reason.

For those who have taken amisulpride + low dose selegiline, do the drugs potentiate each other? Is this a prosocial combo?

Also, has anyone taken adderall/dexedrine + opioid combo?



Xyrem will make you more anxious + talking is bad

Posted by utopizen on June 21, 2004, at 17:25:26

In reply to Xyrem, Amisulpride, Selegiline, Adderall..., posted by Michael Bell on June 20, 2004, at 6:02:38

For some reason your subject includes Xyrem.

If you want Xyrem, then you need to know this isn't a drug you casually try out, like Nardil or Parnate is. (And I say that because those two are very hardcore, but Xyrem is 10x more annoying).

I had to take it for my excessive sleepiness. It's taken at night, since it's got no existence in your bloodstream after 4 hours. That is to say, if you have any plans to take it in the day, you're safer taking crack. No, seriously, crack is safer, I'm not joking, if you plan to take something during the day. (But crack is relatively more dangerous compared to other drugs).

Here's me, three months ago on Xyrem at 6 grams taken in two divided doses each night (oh yeah, the pleasure of taking a drug half-way into the night):

-Vomiting in the middle of the night
-Since it's been used for amnesia, I didn't know I was vomiting the night before until my roommate commented about it 2 weeks into vomiting each night, only after I mentioned how I remembered vomiting the night before to him

-AM Anxiety. Lasts for several hours until about noon. Pretty annoying, so don't go thinking half-life predicts after-effects like this.

-Sweatiness in AM until about noon. I spent $1650 on Botox-A injections into my underarms to stop this, since Drysol didn't help control it.

-Depression. Yup. Along with social lability, so don't think you can hide this to others-- the worst sort of depression you can think of, and it happens the first day after taking it at night.

-Serious depression, by the way.

Oh, yes, it's an neuroprotective. Some really lame kind of neuroprotective. I wish that meant protective from experiencing hell, but no. Just means my neurons didn't die. Sort of like saying, "I feel worse than I would feel if I were in hell right now, but at least this drug isn't damaging my neurons-- so I have some great peace of mind now!"

Okay, and one more thing-- I think I can say this, because I too have some pretty severe social anxiety and once thought I hated Klonopin because it lowered my drive to talk:

Drugs that make you talk, believe me, are exactly the drugs you want to stay away from. One thing is, they will make you talk so much everyone (especially your doc during visits) will assume you're reacting to the stimulants and may have amphetamine psychosis.

Another secret I had to learn the hard way after taking high doses of Desoxyn per my doc's Rx: people don't like others who talk in general.

You will make few friends by talking. You'll make tons if you control your social anxiety and don't talk much. Most people are listeners. You know this, you're smart, and you research this stuff. People who have the most friends tend to ask you questions a lot, don't they?

Because they want you to think they are interested in hearing what you have to say, even if it bores them. Pick up on this and start asking others questions more often, let them finish their sentences, and you'll reduce your friendship deficiency like I did.


Re: Xyrem - can work excellently no side fx

Posted by Anthony Quest on June 26, 2004, at 23:21:52

In reply to Xyrem will make you more anxious + talking is bad, posted by utopizen on June 21, 2004, at 17:25:26

I don't understand how you didn't notice vomit in your room the next day. Anyhow, it sounds like you had miserable side effects. I take the same dose and have no side effects. The second nightly dose is annoying but thats the only thing you and I agree about - Like all medications, it depends on the individual.

Crack is not safer than Xyrem. That is ridiculous to say.

When used twice nightly - Xyrem - unlike benzos does not create dependence or withdrawal while being the only drug that induces sleep and the refreshing deep wave sleep.

It's too bad that it's not available to more people who could benefit.


Re: Xyrem, Amisulpride, Selegiline, Adderall...

Posted by Tmax on July 23, 2004, at 16:24:15

In reply to Xyrem, Amisulpride, Selegiline, Adderall..., posted by Michael Bell on June 20, 2004, at 6:02:38

I started taking my adderall XR 30 mg QD again two weeks after major surgery, when I was still taking Oxycontin 20 mg/BID for postsurgical pain.
This was a fairly potent amphetamine/opiod combo, (though by no means the maximum daily dose of either drug)--and I felt like superman. TWO WEEKS out of thoracic surgery (full pericardiectomy for constrictive pericarditis)and I'm working long hours from home and faxing in work to my office. I was on fire. I felt so good--painfree, lucid, and euphoric (but calm and sustainable-- not like a recreational high).

I had about 10 days of Oxycontin left after I re-started my regular Adderall dose and I felt better (and did more work) in those 10 days than I've ever felt before (even though the entire left side of my upper torso had been sliced open two weeks prior).

Then I ran out of Oxy, the pain came back, and I was in hell for two months.

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