Psycho-Babble Medication Thread 349899

Shown: posts 1 to 25 of 35. This is the beginning of the thread.

 

selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by platinumbride on May 23, 2004, at 14:13:37

I guess some ppl have read my selegiline compounded into a cream posts and seen that I can't be bothered with the uncertainty of it.

I talked to my doc about an maoi, taken in the traditional pill form and mentioned that I wanted to try parnate. He patently refused to prescribe any maoi except for selegiline. He also prescribed an amoino acid (phenyalenine??) along with it.

I have been trying to find things out about this, but everything I read about seleg. in a pill form deals with parkinson's or alzheimer's diseases, and I have only seen one thing about the seleg/phen. study.

Does anyone have any experience with selegiline as an antidepressant? Or with the combination I described above?

Thanks,
Diane

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by linkadge on May 23, 2004, at 16:09:11

In reply to selegiline ONLY (Chemist, KingVultan, SLS??), posted by platinumbride on May 23, 2004, at 14:13:37

This can be an extremely effective antidepressant combination if your depression involves lack of energy and/or motivation. Selegeline is an MAOB inhibitor. MAOB breaks down phenylthalamine.

Thus a combination of the amino acid and a compound which will sustain the action of the amino acid has been shown to be very helpful.

I am really rather envious as I have wanted to try this for a long time.

Best of Luck

Linkadge

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) linkadge

Posted by platinumbride on May 23, 2004, at 16:47:09

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by linkadge on May 23, 2004, at 16:09:11

Thank you, Linkadge, for your input. May I ask why your doc won't let you try this combo?

Diane

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by linkadge on May 23, 2004, at 18:34:28

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??) linkadge, posted by platinumbride on May 23, 2004, at 16:47:09

I don't really have the guts to ask. He seems very old fashoned and orthodox. He would tell me I don't have parkinsons, and that would probably be the end of it.


Linkadge

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) linkadge

Posted by zeugma on May 23, 2004, at 19:14:04

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by linkadge on May 23, 2004, at 18:34:28

selegilene has been used off-label for depression for a long time.

Have you tried any noradrenergic meds- TCA's, Strattera? They are good for motivation but do little for energy, for me. What about stimulants or Provigil?

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by LastDyingWish on May 23, 2004, at 21:04:22

In reply to selegiline ONLY (Chemist, KingVultan, SLS??), posted by platinumbride on May 23, 2004, at 14:13:37

I see my doc on thur. and am pretty sure he is going to prescribe the same combo. It would be very cool if you could keep me updated on your experience with selegiline.

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) platinumbride

Posted by chemist on May 23, 2004, at 22:37:14

In reply to selegiline ONLY (Chemist, KingVultan, SLS??), posted by platinumbride on May 23, 2004, at 14:13:37

> I guess some ppl have read my selegiline compounded into a cream posts and seen that I can't be bothered with the uncertainty of it.
>
> I talked to my doc about an maoi, taken in the traditional pill form and mentioned that I wanted to try parnate. He patently refused to prescribe any maoi except for selegiline. He also prescribed an amoino acid (phenyalenine??) along with it.
>
> I have been trying to find things out about this, but everything I read about seleg. in a pill form deals with parkinson's or alzheimer's diseases, and I have only seen one thing about the seleg/phen. study.
>
> Does anyone have any experience with selegiline as an antidepressant? Or with the combination I described above?
>
> Thanks,
> Diane

chemist here....i cannot think of any reason why you should be taking phenylalanine...there is a tie-in with L-tyrosine, but essentially you have been prescribed a component of an artificial sweetener for food/drinks. the presence of a primary amine does not overshadow the carboxylate group...i would respectfully ask about L-tyorsine in lieu of phenylalanine....all the best, chemist

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) zeugma

Posted by platinumbride on May 23, 2004, at 23:57:54

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??) linkadge, posted by zeugma on May 23, 2004, at 19:14:04

> selegilene has been used off-label for depression for a long time.
>
> Have you tried any noradrenergic meds- TCA's, Strattera? They are good for motivation but do little for energy, for me. What about stimulants or Provigil?

Well, I kind of ruled out tcas because I cannot risk more weight gain (and I gained a ton on remeron and ssris). Plus, my doc frankly never mentioned them. I think he really is only willing to do anything with an maoi because he read about the selegeline/phenylalanine study some years ago. he always seems to dig anything that has some kind of "natural medicine" component to it. That is the extent of his "experimenting". (Went nuts over sam-e)
He seems to stick with modern day ads - except for effexor.

Don't know much about strattera but I imagine he would look at me sideways since the commercials all have that idiotic woman with the "channel changing in her head" (at least in the states).

I guess I will give this combination a chance. I seem to be running out of options, unless I find a doctor with different leanings....

Diane

 

will do :-) (nm) LastDyingWish

Posted by platinumbride on May 24, 2004, at 0:14:05

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by LastDyingWish on May 23, 2004, at 21:04:22

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) linkadge

Posted by platinumbride on May 24, 2004, at 0:20:40

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by linkadge on May 23, 2004, at 18:34:28

> I don't really have the guts to ask. He seems very old fashoned and orthodox. He would tell me I don't have parkinsons, and that would probably be the end of it.
>
>
> Linkadge

I'm sorry for that. Sounds like you aren't too thrilled. I hope greener pastures are ahead somehow, for you.

Diane

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??) chemist

Posted by platinumbride on May 24, 2004, at 0:27:19

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??) platinumbride, posted by chemist on May 23, 2004, at 22:37:14

>
>
> chemist here....i cannot think of any reason why you should be taking phenylalanine...there is a tie-in with L-tyrosine, but essentially you have been prescribed a component of an artificial sweetener for food/drinks. the presence of a primary amine does not overshadow the carboxylate group...i would respectfully ask about L-tyorsine in lieu of phenylalanine....all the best, chemist

Chemist, thank you, but my doc refers to research charted in some psychiatric journal vis. the phenyl. I, too, thought this was a dumb thing for anyone to have tried, given that it is part of aspartame (maybe I should just drink a lot of diet soda ha ha)

At any rate, someone posted this link some time ago. I haven't bothered to re read it, but i think it charts some numbers and such.

http://deprenyl.info/Deprenyl/deprenyl-27.htm

Diane

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by elleff on May 24, 2004, at 0:34:16

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??) platinumbride, posted by chemist on May 23, 2004, at 22:37:14

> > I guess some ppl have read my selegiline compounded into a cream posts and seen that I can't be bothered with the uncertainty of it.
> >
> > I talked to my doc about an maoi, taken in the traditional pill form and mentioned that I wanted to try parnate. He patently refused to prescribe any maoi except for selegiline. He also prescribed an amoino acid (phenyalenine??) along with it.
> >
> > I have been trying to find things out about this, but everything I read about seleg. in a pill form deals with parkinson's or alzheimer's diseases, and I have only seen one thing about the seleg/phen. study.
> >
> > Does anyone have any experience with selegiline as an antidepressant? Or with the combination I described above?
> >
> > Thanks,
> > Diane
>
> chemist here....i cannot think of any reason why you should be taking phenylalanine...there is a tie-in with L-tyrosine, but essentially you have been prescribed a component of an artificial sweetener for food/drinks. the presence of a primary amine does not overshadow the carboxylate group...i would respectfully ask about L-tyorsine in lieu of phenylalanine....all the best, chemist

Maybe there could be some sense behind it from the perspective that

1. The principle substrates for MAO-B in the brain are dopamine and PEA, which functions as a catecholaminergic enhancer. PEA is derived from phenylalanine I understand.

2. Sabelli's very positive studies of treatment resistant depressives using combinations of either selegilene and PEA or selegilene and phenylalanine in the 1980s.

Diane, be sure to take your phenylalanine on a completely empty stomach because amino acid transport into the brain is competetive and consequently other protein in the diet will reduce it's effectiveness.

regards

elleff

 

Re: selegiline + dopamine increase ?

Posted by btnd on May 24, 2004, at 6:29:37

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by elleff on May 24, 2004, at 0:34:16


> > > I have been trying to find things out about this, but everything I read about seleg. in a pill form deals with parkinson's or alzheimer's diseases, and I have only seen one thing about the seleg/phen. study.

> 2. Sabelli's very positive studies of treatment resistant depressives using combinations of either selegilene and PEA or selegilene and phenylalanine in the 1980s.


Here is the study. It was by Birkmayer. I don't know about Sabelli studies - can you post them?
Anyways, Birkmayer study shows TERRIFIC RESULTS. I'm wondering whether ANYTHING that increases dopamine (be it phenylalanine, GHB, L-Tyrosine, L-Dopa, Carvodopa) could work with Selegiline?

L-deprenyl plus L-phenylalanine in the treatment of depression

Birkmayer, W

J Neural Transmission. (AUSTRIA), 1984, 59/1 (81-87)

ABSTRACT

The antidepressive efficacy of deprenyl (5-10 mg daily) plus L-phenylalanine (205 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of L-phenylethylamine in the brain.

 

Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by SLS on May 24, 2004, at 8:52:34

In reply to selegiline ONLY (Chemist, KingVultan, SLS??), posted by platinumbride on May 23, 2004, at 14:13:37

I guess it is worth a try. It is hard to ignore the many reports of the successful use of selegiline to treat depression.

I have seen arguments made for the use of either tyrosine of phenylalanine as an adjunct. Tyrosine is one step closer than phenylalanine to synthesizing neurotransmitters. However, using phenylalanine produces an increase in PEA through a side-reaction, perhaps adding a stimulant-like mood brightening effect. These are rather simplistic arguments, and I don't know that there have ever been studies to compare the two. In the past, there have been posters here on PB who have demonstrated much greater expertise on this subject than I. You might have some luck using the PB/Google search using "AndrewB" and "Adam" as a keywords. You are bound to find a few threads.

Try this:

http://www.google.com/search?q=%28andrewb+OR+adam%29+AND+%28deprenyl+OR+selegiline+OR+eldepryl%29&sitesearch=dr-bob.org

Historically, selegiline has not been considered to be a very effective antidepressant, although that is what it was initially developed as. Nevertheless, there have always been a few psychopharmacologists whom have embraced selegiline. When treating depression, the dosage of selegiline necessary to elicit an antidepressant response is higher than when it is used for Parkinsons.

Parkinsons:
5-10mg

Depression:
20-60mg (oral)
20mg (transdermal patch)

When taking selegiline orally at dosages above 10mg, it is recommended that one follow a special tyramine restricted diet. Supposedly, this is not necessary when using the transdermal patch.

It is my impression that selegiline is not as potent an antidepressant as Nardil or Parnate. The bottom line is that no one here is smart enough to predict with certainty whether or not selegiline will work for you.

Good luck.


- Scott

 

Re: selegiline + dopamine increase ?

Posted by Ilene on May 24, 2004, at 9:00:41

In reply to Re: selegiline + dopamine increase ?, posted by btnd on May 24, 2004, at 6:29:37

> L-deprenyl plus L-phenylalanine in the treatment of depression
>
> Birkmayer, W
>
> J Neural Transmission. (AUSTRIA), 1984, 59/1 (81-87)
>
> ABSTRACT
>
> The antidepressive efficacy of deprenyl (5-10 mg daily) plus L-phenylalanine (205 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of L-phenylethylamine in the brain.
>


Because this study is 20 years old I thought there would be some follow-up, so I went into Medline and looked. I found very little, except about Parkinsons Disease. Looks like this research went nowhere. I wonder why. Someone with access to an academic library might look in the Science Citation Index/Web of Science.

I.

 

phenylthylamine works differently than other dopam

Posted by linkadge on May 24, 2004, at 10:30:15

In reply to Re: selegiline + dopamine increase ?, posted by Ilene on May 24, 2004, at 9:00:41

phenylthylamine works differently than other dopimanergics.

I found that when I take phenylthylamine I am truely a nicer kinder person. I am more in love with people and care about the grand scheme of things.

When I take plain old ritalin or dexdrine I couldn't give a care.

PEA is a strange chemical and is very distinct from other dopimanergic agents.

Linkadge

 

Re: selegiline + dopamine increase ?

Posted by platinumbride on May 24, 2004, at 11:30:15

In reply to Re: selegiline + dopamine increase ?, posted by Ilene on May 24, 2004, at 9:00:41

Hi, and thank you all so much for yur input.

As far as updates on tis sttudy, all I know is tht my doc read of some similar study done within at least the past 4 years, in some psychiatric journak in America (I forgot the name....memory sucks due to either depression, anxiety or being in the middle of a neurontin dose). That was teh basis of his prescription.

Personally, I am sick of trying "natural" remedies, as I have had no success with tthem, and have been trying them even before the 8 yers or so tht I have been on the chemical route, but one must keep an open mind...

I would have preferred parnate or marplan, but he just won't do it. Very worried about the high doses required, the dietary and med interaction issues and a patient who came to him fresh from the hospital with a botched suicide attempt.

I just want to say one more thing:

My insurance company has some ridiculous way of deciding what drugs it will assign a low co-pay to. They SAY that it is based on their research of the best drugs available to treat conditions. Sooooo, seligeline is an "approved" drug in their book for PARKINSONS, so I just pay a nominal co-pay for it, as it is generic. Nardil and parnate have very high co-pays. To get marplan, the doc has to write a friggin' dissertation! I was pretty shocked at that one. You cant even get ambien without a song and dance from the doctor, because their modern hypnitic of choice is sonata. Same with abilify or seroquel, because they like zyprexa or risperidol.

Sorry to rant, but, parnate and nardil are generics!!!!

Anyway, I guess the shot in the dark with this will begin today IF my pharmacy has managed to get seligeline in stock....

many many thanks,

Diane

> > L-deprenyl plus L-phenylalanine in the treatment of depression
> >
> > Birkmayer, W
> >
> > J Neural Transmission. (AUSTRIA), 1984, 59/1 (81-87)
> >
> > ABSTRACT
> >
> > The antidepressive efficacy of deprenyl (5-10 mg daily) plus L-phenylalanine (205 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of L-phenylethylamine in the brain.
> >
>
>
> Because this study is 20 years old I thought there would be some follow-up, so I went into Medline and looked. I found very little, except about Parkinsons Disease. Looks like this research went nowhere. I wonder why. Someone with access to an academic library might look in the Science Citation Index/Web of Science.
>
> I.
>

 

Re: phenylthylamine works differently than other dopam

Posted by platinumbride on May 24, 2004, at 11:33:33

In reply to phenylthylamine works differently than other dopam, posted by linkadge on May 24, 2004, at 10:30:15

If this is so much gentler, I begin to wonder if I should try it rather than phenylalanine. I don't want to faced with divorce papers because I am a nasty %*^!!!

Diane

> phenylthylamine works differently than other dopimanergics.
>
> I found that when I take phenylthylamine I am truely a nicer kinder person. I am more in love with people and care about the grand scheme of things.
>
> When I take plain old ritalin or dexdrine I couldn't give a care.
>
> PEA is a strange chemical and is very distinct from other dopimanergic agents.
>
> Linkadge
>

 

Re: selegiline + dopamine increase ? platinumbride

Posted by King Vultan on May 24, 2004, at 12:38:42

In reply to Re: selegiline + dopamine increase ?, posted by platinumbride on May 24, 2004, at 11:30:15

>
> I would have preferred parnate or marplan, but he just won't do it. Very worried about the high doses required, the dietary and med interaction issues and a patient who came to him fresh from the hospital with a botched suicide attempt.
>


I've posted this link on this board several times before, but perhaps it might do something to convince your doctor that the irreversible MAOIs are not so bad:

http://www.currentpsychiatry.com/2002_06/06_02_maoi.asp


> I just want to say one more thing:
>
> My insurance company has some ridiculous way of deciding what drugs it will assign a low co-pay to. They SAY that it is based on their research of the best drugs available to treat conditions. Sooooo, seligeline is an "approved" drug in their book for PARKINSONS, so I just pay a nominal co-pay for it, as it is generic. Nardil and parnate have very high co-pays. To get marplan, the doc has to write a friggin' dissertation! I was pretty shocked at that one. You cant even get ambien without a song and dance from the doctor, because their modern hypnitic of choice is sonata. Same with abilify or seroquel, because they like zyprexa or risperidol.
>
> Sorry to rant, but, parnate and nardil are generics!!!!
>

Actually, in the US, Parnate and Nardil are brand names, with no generics available. I assume the reason is because they are so rarely prescribed, it is not worth it for the generic companies to bother with them. In a three tier copay system, the two drugs are typically in the middle "formulary" category. On my current plan, both are a $25 copay, while true generics are $10. The cash price for a month's worth of Nardil at 6 pills/day (90 mg) is $125 at Walgreen's, so I am getting a very good deal.

However, some of the other copays my insurance company has are ridiculous and arbitrary, such as $50 for Ambien. I am going to see my GP today about another matter where I was hoping a $10 copay generic drug would work as well as the insanely priced $50 copay alternative (this for approximately $71 of medication for someone paying cash). Sadly, it looks like I am going to have to go back to the expensive stuff. Maybe I should count my blessings, though, as it is still better than not having insurance at all.

Todd

 

Re: selegiline + dopamine increase ?

Posted by Ilene on May 24, 2004, at 13:00:24

In reply to Re: selegiline + dopamine increase ? platinumbride, posted by King Vultan on May 24, 2004, at 12:38:42

> >
> > I would have preferred parnate or marplan, but he just won't do it. Very worried about the high doses required, the dietary and med interaction issues and a patient who came to him fresh from the hospital with a botched suicide attempt.
> >
>
>
> I've posted this link on this board several times before, but perhaps it might do something to convince your doctor that the irreversible MAOIs are not so bad:
>
> http://www.currentpsychiatry.com/2002_06/06_02_maoi.asp
>
>
I gave this article to my pdoc, and she was very appreciative. She doesn't have a problem with having me make suggestions or arguing against her recommendations, however. I'm pretty lucky in that respect.

 

thanks for the info, elleff!!! (nm) elleff

Posted by chemist on May 24, 2004, at 16:30:32

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??), posted by elleff on May 24, 2004, at 0:34:16

 

correction: thanks to all for info! (nm)

Posted by chemist on May 24, 2004, at 16:31:49

In reply to Re: selegiline + dopamine increase ?, posted by btnd on May 24, 2004, at 6:29:37

 

Re: selegiline + dopamine increase ?

Posted by elleff on May 24, 2004, at 20:38:20

In reply to Re: selegiline + dopamine increase ?, posted by btnd on May 24, 2004, at 6:29:37


> Here is the study. It was by Birkmayer. I don't know about Sabelli studies - can you post them?

Here they are:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1900832

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8044048

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9081552

By the way, there would be reason to suspect that adding supplemental chromium (the anti-dysthymic effects of which have been well demonstrated - see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12559660) to oral phenylalanine supplementation should produce at least addative effects because chromium seems to work by increasing the insulin-mediated transport of aromatic and branch chain amino acids across the BBB (see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14571351)

regards

elleff

 

Phenethylamine, and selegeline + phenylalanine elleff

Posted by Questionmark on May 25, 2004, at 1:16:26

In reply to Re: selegiline + dopamine increase ?, posted by elleff on May 24, 2004, at 20:38:20

Wow, i don't ever remember seeing that third abstract you (elleff) posted before. i didn't know you could actually get phenylethylamine in exogenous oral form. i knew that much phenylalanine will be converted to PEA if taken with selegeline, but we are able to get PEA by itself?? Or, at least, it exists anyway, since the researchers in that study used it. So why isn't it sold anywhere?! Would i be able to get it if i wanted??
i mean, seriously, how promising does that abstract make PEA sound? Can anybody answer some of the above questions?

Oh, also, P.S.--
i hAVe read that one abstract before, showing the incredibly positive results of using selegeline and phenylalanine for depression. How amazing is that?!! What was it-- 80% responded? That's crAzy. i had mostly forgot about that study. But yeah-- why the heck does/did that study not have more impact than it does/did? Why aren't we using that combination more often??


>
> > Here is the study. It was by Birkmayer. I don't know about Sabelli studies - can you post them?
>
> Here they are:
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1900832
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8044048
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9081552
>
> By the way, there would be reason to suspect that adding supplemental chromium (the anti-dysthymic effects of which have been well demonstrated - see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12559660) to oral phenylalanine supplementation should produce at least addative effects because chromium seems to work by increasing the insulin-mediated transport of aromatic and branch chain amino acids across the BBB (see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14571351)
>
> regards
>
> elleff

 

Re: Phenethylamine, and selegeline + phenylalanine

Posted by elleff on May 25, 2004, at 1:28:05

In reply to Phenethylamine, and selegeline + phenylalanine elleff, posted by Questionmark on May 25, 2004, at 1:16:26

> Wow, i don't ever remember seeing that third abstract you (elleff) posted before. i didn't know you could actually get phenylethylamine in exogenous oral form. i knew that much phenylalanine will be converted to PEA if taken with selegeline, but we are able to get PEA by itself?? Or, at least, it exists anyway, since the researchers in that study used it. So why isn't it sold anywhere?! Would i be able to get it if i wanted??
> i mean, seriously, how promising does that abstract make PEA sound? Can anybody answer some of the above questions?
>
> Oh, also, P.S.--
> i hAVe read that one abstract before, showing the incredibly positive results of using selegeline and phenylalanine for depression. How amazing is that?!! What was it-- 80% responded? That's crAzy. i had mostly forgot about that study. But yeah-- why the heck does/did that study not have more impact than it does/did? Why aren't we using that combination more often??

I think the reason phenylethylamine is not commercially available, through pharmaceutical sources at least, is that it is readily convertible into amphetamine. There is, after all, only one methyl group between them: dexamphetamine is, of course "dextro-alpha-methyl-phenylethylamine".

I suspect that the reason this protocol has languished is the above, plus the absence of significant commercial drivers of selegilene.

regards

elleff


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