![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 37. This is the beginning of the thread.
Posted by fuji on May 19, 2004, at 18:15:54
Anyone know what a typical wash out period would be from ssri to maoi? I am about 5 days off of efexr but my doc wants me to be 5 (yes, she said 5) weeks off of prozac & 2 weeks off efxr. That means five unmedicated weeks for the first time in about 13 years. Pretty freakin' scary in my book!
Posted by snapper on May 19, 2004, at 18:43:01
In reply to wash-out before maoi, posted by fuji on May 19, 2004, at 18:15:54
Yes, pretty freakin scary but the absolute safest way to switch from ssri's and the like over to the maois. especially Prozac! your doc is not just covering her butt, but also has your health/safety in mind...you can do it though so good luck and try to remember the goal you are shooting for! 5 weeks is a long time but will probably go faster than you realize!
snapper
Posted by flipsactown on May 19, 2004, at 21:34:45
In reply to Re: wash-out before maoi, posted by snapper on May 19, 2004, at 18:43:01
I had been taking Prozac the better part of 10 years and finally decided to stop due to the poop out factor and try Nardil. I was aware of the 5 week washout period, but because my unipolar depression had gotten so brutal, out of desperation, I took a chance and started Nardil after 3 weeks. Fortunately, I did not have any bad reactions, but as everyone knows everyone reacts differently.
My depression seemed to be in check but because of severe insomnia, I had to reduce my Nardil from 60 to 30mgs and although I am now able to get at least 5 hours continuous sleep, my depression seems to have returned. I will cautiously increase my dosage back up to 45mg then 60mg, and hope that my depression lifts. I am taking Ambien for the insomnia.
FST
> Yes, pretty freakin scary but the absolute safest way to switch from ssri's and the like over to the maois. especially Prozac! your doc is not just covering her butt, but also has your health/safety in mind...you can do it though so good luck and try to remember the goal you are shooting for! 5 weeks is a long time but will probably go faster than you realize!
> snapper
Posted by King Vultan on May 20, 2004, at 7:43:53
In reply to wash-out before maoi, posted by fuji on May 19, 2004, at 18:15:54
> Anyone know what a typical wash out period would be from ssri to maoi? I am about 5 days off of efexr but my doc wants me to be 5 (yes, she said 5) weeks off of prozac & 2 weeks off efxr. That means five unmedicated weeks for the first time in about 13 years. Pretty freakin' scary in my book!
Yes, unfortunately, five weeks is a prudent washout period for Prozac because of its ridiculously long half life. If I were in your place, I would be apprehensive about waiting any less time than that. I do understand your concerns about being unmedicated for that length of time, as I also had to go through a washout period when switching to an MAOI (and then another period when the dosage I was taking was insufficient), but perhaps there will be enough residual effects on receptor densities from the drugs you've been taking to aid you in the transition.Todd
Posted by fuji on May 20, 2004, at 20:13:29
In reply to Re: wash-out before maoi » snapper, posted by flipsactown on May 19, 2004, at 21:34:45
Thanks for all the replies. Today I was thinking I could substitute something for the first 3 weeks of prozac washout and then have two weeks off of whatever I substituted or then of course I could just bite the bullet and do the five weeks. Is Nardil activating and is that the reason for insomnia?
Posted by Sad Panda on May 20, 2004, at 23:09:26
In reply to Re: wash-out before maoi, posted by fuji on May 20, 2004, at 20:13:29
> Thanks for all the replies. Today I was thinking I could substitute something for the first 3 weeks of prozac washout and then have two weeks off of whatever I substituted or then of course I could just bite the bullet and do the five weeks. Is Nardil activating and is that the reason for insomnia?
>Nortriptyline or Desipramine would be ideal candidates, they are safe with MAOI's & you could take them for the 5 weeks before starting Nardil easily. They may or may not be helpfull to you but atleast you would have some drug side effects to occupy your mind with. :)
Cheers,
Panda.
Posted by King Vultan on May 21, 2004, at 7:26:26
In reply to Re: wash-out before maoi, posted by fuji on May 20, 2004, at 20:13:29
> Thanks for all the replies. Today I was thinking I could substitute something for the first 3 weeks of prozac washout and then have two weeks off of whatever I substituted or then of course I could just bite the bullet and do the five weeks. Is Nardil activating and is that the reason for insomnia?
Nardil is actually somewhat sedating, particularly when compared to the other MAOI, Parnate. I believe the reason for the insomnia is the increase in availability of serotonin and norepinephrine, which can have a negative effect on sleep, at least for some people. I had bad insomnia on the two SSRIs I've tried, Zoloft and Prozac, moderate insomnia on some of the selective norepinephrine reuptake inhibitors I've tried, such as Strattera and desipramine, and terrible insomnia on Effexor, which works on both serotonin and norepinephrine, so the terrible insomnia I've experienced on Nardil is not unexpected.Todd
Posted by Sad Panda on May 21, 2004, at 7:38:45
In reply to Re: wash-out before maoi » fuji, posted by King Vultan on May 21, 2004, at 7:26:26
> > Thanks for all the replies. Today I was thinking I could substitute something for the first 3 weeks of prozac washout and then have two weeks off of whatever I substituted or then of course I could just bite the bullet and do the five weeks. Is Nardil activating and is that the reason for insomnia?
>
>
> Nardil is actually somewhat sedating, particularly when compared to the other MAOI, Parnate. I believe the reason for the insomnia is the increase in availability of serotonin and norepinephrine, which can have a negative effect on sleep, at least for some people. I had bad insomnia on the two SSRIs I've tried, Zoloft and Prozac, moderate insomnia on some of the selective norepinephrine reuptake inhibitors I've tried, such as Strattera and desipramine, and terrible insomnia on Effexor, which works on both serotonin and norepinephrine, so the terrible insomnia I've experienced on Nardil is not unexpected.
>
> Todd
>
>You need some H1 blockade to set your mind into sleep mode & some 5-HT2A blockade to keep it there. :)
Cheers,
Panda.
Posted by King Vultan on May 21, 2004, at 12:25:12
In reply to Re: wash-out before maoi » King Vultan, posted by Sad Panda on May 21, 2004, at 7:38:45
>
> You need some H1 blockade to set your mind into sleep mode & some 5-HT2A blockade to keep it there. :)
>
> Cheers,
> Panda.
>
>Hey there Panda,
I know Remeron has those characteristics, but after my negative experience with trazodone, I am done with sedating antidepressants, as I have found nortriptyline difficult to tolerate also. I am getting some H1 blockade from the Benadryl I am currently taking but wake up several times a night. I've already decided to ask my pdoc about stuff like Halcion or Restoril, which I can take every other night or whatever is necessary to avoid any dependency/tolerance issues. I am not going to take the damned atypical antipsychotic he had brought up at my last visit. It's too expensive, and I have grave misgivings about this class of drugs being prescribed for people with unipolar depression who are just suffering insomnia because of their AD meds.
Todd
Posted by PhoenixGirl on May 21, 2004, at 22:14:26
In reply to Re: wash-out before maoi, posted by King Vultan on May 21, 2004, at 12:25:12
I feel your pain, I'm about to start a wash-out period before I start Parnate. It's so scary, considering my depression has been so brutal as to require ECT.
I wanted to ask the other people here who have taken MAOIs -- How does it affect your libido and sexual function?
Posted by flipsactown on May 21, 2004, at 22:39:55
In reply to I feel your pain. (Have MAOI sex question too), posted by PhoenixGirl on May 21, 2004, at 22:14:26
I have been taking Nardil over 6 weeks and switched from Prozac after taking it for over 7 years. The ideal washout period for Nardil from an SSRI, like Prozac, is 5 weeks. However, my unipolar depression became so brutal after only 3 weeks, I took a chance out of desperation at only 3 weeks. Fortunately, I had no side effects. As far as libido is concerned, surprisingly, for me it was business as usual. As far as the effectiveness of Nardil, it seemed to lift my depression very well but the insomnia SE has been brutal. With my pdocs blessings, I reduced my dosage by one half. Although I am able to sleep at least 5 continuous hours now, on half my dose, my depression has returned. I will slowly increase it again and probably will take something for sleep to curve my insomnia.
FST
Posted by gardenergirl on May 21, 2004, at 23:57:26
In reply to I feel your pain. (Have MAOI sex question too), posted by PhoenixGirl on May 21, 2004, at 22:14:26
Phoenixgirl,
I initially had anorgasmia when I started Nardil. This lasted for probably at least three months. At some point it went away, along with most of my other side effects.gg
Posted by Sad Panda on May 22, 2004, at 5:48:33
In reply to Re: wash-out before maoi, posted by King Vultan on May 21, 2004, at 12:25:12
> >
> > You need some H1 blockade to set your mind into sleep mode & some 5-HT2A blockade to keep it there. :)
> >
> > Cheers,
> > Panda.
> >
> >
>
> Hey there Panda,
>
> I know Remeron has those characteristics, but after my negative experience with trazodone, I am done with sedating antidepressants, as I have found nortriptyline difficult to tolerate also. I am getting some H1 blockade from the Benadryl I am currently taking but wake up several times a night. I've already decided to ask my pdoc about stuff like Halcion or Restoril, which I can take every other night or whatever is necessary to avoid any dependency/tolerance issues. I am not going to take the damned atypical antipsychotic he had brought up at my last visit. It's too expensive, and I have grave misgivings about this class of drugs being prescribed for people with unipolar depression who are just suffering insomnia because of their AD meds.
>
> Todd
>
>Hi Todd,
What sort of bad rections did you have to trazodone & nortriptyline? I am against the atypical AP for sleep for unipolar people, but they may be a good option for bipolar people needing sleep & mood stabization.
Cheers,
Panda.
Posted by King Vultan on May 22, 2004, at 11:35:33
In reply to Re: wash-out before maoi » King Vultan, posted by Sad Panda on May 22, 2004, at 5:48:33
>
> Hi Todd,
>
> What sort of bad rections did you have to trazodone & nortriptyline? I am against the atypical AP for sleep for unipolar people, but they may be a good option for bipolar people needing sleep & mood stabization.
>
> Cheers,
> Panda.
>
I found nortriptyline dreadfully sedating, and it also had a dual depressant/antidepressant action. I would go down in the dumps at first on a dosage increase, but then my spirits would gradually rise. Trazodone was a pure depressant for me and made me feel so depressed and out of sorts the next day after taking it that I dumped it after just a few days.I'm not sure what's going on with these drugs, but because I get such an immediate and positive response from SSRI type drugs (in as little as four hours with 25-50 mg Zoloft in a depressed and recently unmedicated state), perhaps my system is just geared more for this kind of drug than these atypical antidepressants. Nortripyline, at least, is a selective norepinephrine reuptake inhibitor, on top of the other things it does, and I'm convinced this is the only reason it had any antidepressant efficacy. Trazodone has very little direct effect on either serotonin or norepinephrine reuptake. I expect I would also react very badly to Serzone, which has a very similar pharmacology.
Todd
Posted by fuji on May 22, 2004, at 12:00:13
In reply to Re: wash-out before maoi » fuji, posted by King Vultan on May 21, 2004, at 7:26:26
It's interesting because most things sedate me whether they should or not. Provigil and coffee put me out like a light. So far the only thing that keeps me awake is anxiety but even then it's not that bad. Prozac, wellbutrin and effextor never keep me awake. Actually they are more like sleeping pills. Maybe I can go to sleep for the next 5 weeks!!
It seems that more people take Nardil. Any parnate folks out there with a couple of cents to throw in???
Posted by Questionmark on May 22, 2004, at 14:58:25
In reply to I feel your pain. (Have MAOI sex question too), posted by PhoenixGirl on May 21, 2004, at 22:14:26
> I wanted to ask the other people here who have taken MAOIs -- How does it affect your libido and sexual function?
For me, and for most people, Nardil has a negative effect on libido, but Parnate has a tremendously positive effect on libido and sexual function and pleasure.
Posted by Questionmark on May 22, 2004, at 15:01:50
In reply to Re: wash-out before maoi » Sad Panda, posted by King Vultan on May 22, 2004, at 11:35:33
>
>
> >
> > Hi Todd,
> >
> > What sort of bad rections did you have to trazodone & nortriptyline? I am against the atypical AP for sleep for unipolar people, but they may be a good option for bipolar people needing sleep & mood stabization.
> >
> > Cheers,
> > Panda.
> >
>
> I found nortriptyline dreadfully sedating, and it also had a dual depressant/antidepressant action. I would go down in the dumps at first on a dosage increase, but then my spirits would gradually rise. Trazodone was a pure depressant for me and made me feel so depressed and out of sorts the next day after taking it that I dumped it after just a few days.
>
> I'm not sure what's going on with these drugs, but because I get such an immediate and positive response from SSRI type drugs (in as little as four hours with 25-50 mg Zoloft in a depressed and recently unmedicated state), perhaps my system is just geared more for this kind of drug than these atypical antidepressants. Nortripyline, at least, is a selective norepinephrine reuptake inhibitor, on top of the other things it does, and I'm convinced this is the only reason it had any antidepressant efficacy. Trazodone has very little direct effect on either serotonin or norepinephrine reuptake. I expect I would also react very badly to Serzone, which has a very similar pharmacology.
>
> Toddi'm the exact same way: w/ antihistamines (other antihistamines-- never tried a TCA or trazadone) and SSRIs.
Posted by Sad Panda on May 23, 2004, at 1:33:07
In reply to Re: wash-out before maoi » Sad Panda, posted by King Vultan on May 22, 2004, at 11:35:33
>
>
> >
> > Hi Todd,
> >
> > What sort of bad rections did you have to trazodone & nortriptyline? I am against the atypical AP for sleep for unipolar people, but they may be a good option for bipolar people needing sleep & mood stabization.
> >
> > Cheers,
> > Panda.
> >
>
> I found nortriptyline dreadfully sedating, and it also had a dual depressant/antidepressant action. I would go down in the dumps at first on a dosage increase, but then my spirits would gradually rise. Trazodone was a pure depressant for me and made me feel so depressed and out of sorts the next day after taking it that I dumped it after just a few days.
>
> I'm not sure what's going on with these drugs, but because I get such an immediate and positive response from SSRI type drugs (in as little as four hours with 25-50 mg Zoloft in a depressed and recently unmedicated state), perhaps my system is just geared more for this kind of drug than these atypical antidepressants. Nortripyline, at least, is a selective norepinephrine reuptake inhibitor, on top of the other things it does, and I'm convinced this is the only reason it had any antidepressant efficacy. Trazodone has very little direct effect on either serotonin or norepinephrine reuptake. I expect I would also react very badly to Serzone, which has a very similar pharmacology.
>
> Todd
>
>Trazodone, Serzone & Nortriptyline are all 5-HT2A & Alpha-1 NE blockers, I'd be interested to know which receptor blockade causes you grief. A Remeron trial could be revealing, it stands out from the other sedating AD's because it doesn't block Alpha-1 NE.
Have you tried the other antihistamine for sleep like Phenergan & Polaramine? Phenergan might be bad, I think it would hit a bunch of receptors.
Cheers,
Panda.
Posted by King Vultan on May 24, 2004, at 8:03:25
In reply to Re: wash-out before maoi » King Vultan, posted by Sad Panda on May 23, 2004, at 1:33:07
> >
>
> Trazodone, Serzone & Nortriptyline are all 5-HT2A & Alpha-1 NE blockers, I'd be interested to know which receptor blockade causes you grief. A Remeron trial could be revealing, it stands out from the other sedating AD's because it doesn't block Alpha-1 NE.
>
> Have you tried the other antihistamine for sleep like Phenergan & Polaramine? Phenergan might be bad, I think it would hit a bunch of receptors.
>
> Cheers,
> Panda.
>
>
>My theory is that it is these drugs' blockade of 5HT-1 receptors that is responsible. For trazodone I have a reference showing these Ki values in order of strength:
alpha-1..... 12 +/- 0.2
5-HT2A..... 20 +/- 1
5-HT1A..... 29 +/- 1
alpha-2..... 106 +/- 2Furthermore, the trazodone metabolite mCPP shows these Ki values:
5-HT1A..... 16 +/- 0.2
alpha-1..... 97 +/- 3
5-HT2A..... 110 +/- 3So for the parent molecule, the 5-HT1A blockade is the 3rd most powerful--and of roughly the same order of magnitude as the alpha-1 blockade. For mCPP, the 5-HT1A blockade is by far the most powerful.
So what does this mean? I'm not sure, but I bring it up because the 5-HT1A receptor seems like a strange one for an antidepressant to be blockading. After all, the presynaptic 5-HT1A receptor is the initial target and the postsynaptic 5-HT1A receptor is the ultimate target for SSRIs to stimulate. To me, it doesn't sound like a great idea to be blockading this receptor, but trazodone--and Serzone, which has a very similar pharmacology--obviously work as antidepressants for some people. My theory is that this weird 5-HT1A blockade business is one of the reasons these drugs are viewed by some as marginal antidepressants. I also think that someone like myself who reacts very strongly and quickly to an SSRI will have a greater chance of finding Serzone and trazodone to be disappointing.
As for nortriptyline, I don't have statistical data, but in the receptor chart in "Psychotropic Drugs", its Ki for 5-HT1 blockade, represented by ++, is higher than most of the tricyclics, and it also has only a relatively weak blockade of serotonin reuptake to counterbalance it (its most powerful effect is its blockade of NE reuptake). I found nortriptyline to have kind of a dual action, as in one way I was getting a lift, and in another I was going down in the dumps. There was enough lift, however, that there was a net antidepressant effect.
None of this appears to apply to Remeron, which my book shows has zero effect on blockading 5-HT1A receptors. I'm more optimistic that this drug would have antidepressant effects for me, but I am not enthusiastic about trying it due to possible oversedation and weight gain problems.
Todd
Posted by Sad Panda on May 24, 2004, at 8:38:15
In reply to Re: wash-out before maoi, posted by King Vultan on May 24, 2004, at 8:03:25
> > >
> >
> > Trazodone, Serzone & Nortriptyline are all 5-HT2A & Alpha-1 NE blockers, I'd be interested to know which receptor blockade causes you grief. A Remeron trial could be revealing, it stands out from the other sedating AD's because it doesn't block Alpha-1 NE.
> >
> > Have you tried the other antihistamine for sleep like Phenergan & Polaramine? Phenergan might be bad, I think it would hit a bunch of receptors.
> >
> > Cheers,
> > Panda.
> >
> >
> >
>
> My theory is that it is these drugs' blockade of 5HT-1 receptors that is responsible. For trazodone I have a reference showing these Ki values in order of strength:
>
> alpha-1..... 12 +/- 0.2
> 5-HT2A..... 20 +/- 1
> 5-HT1A..... 29 +/- 1
> alpha-2..... 106 +/- 2
>
> Furthermore, the trazodone metabolite mCPP shows these Ki values:
>
> 5-HT1A..... 16 +/- 0.2
> alpha-1..... 97 +/- 3
> 5-HT2A..... 110 +/- 3
>
> So for the parent molecule, the 5-HT1A blockade is the 3rd most powerful--and of roughly the same order of magnitude as the alpha-1 blockade. For mCPP, the 5-HT1A blockade is by far the most powerful.
>
> So what does this mean? I'm not sure, but I bring it up because the 5-HT1A receptor seems like a strange one for an antidepressant to be blockading. After all, the presynaptic 5-HT1A receptor is the initial target and the postsynaptic 5-HT1A receptor is the ultimate target for SSRIs to stimulate. To me, it doesn't sound like a great idea to be blockading this receptor, but trazodone--and Serzone, which has a very similar pharmacology--obviously work as antidepressants for some people. My theory is that this weird 5-HT1A blockade business is one of the reasons these drugs are viewed by some as marginal antidepressants. I also think that someone like myself who reacts very strongly and quickly to an SSRI will have a greater chance of finding Serzone and trazodone to be disappointing.
>
> As for nortriptyline, I don't have statistical data, but in the receptor chart in "Psychotropic Drugs", its Ki for 5-HT1 blockade, represented by ++, is higher than most of the tricyclics, and it also has only a relatively weak blockade of serotonin reuptake to counterbalance it (its most powerful effect is its blockade of NE reuptake). I found nortriptyline to have kind of a dual action, as in one way I was getting a lift, and in another I was going down in the dumps. There was enough lift, however, that there was a net antidepressant effect.
>
> None of this appears to apply to Remeron, which my book shows has zero effect on blockading 5-HT1A receptors. I'm more optimistic that this drug would have antidepressant effects for me, but I am not enthusiastic about trying it due to possible oversedation and weight gain problems.
>
> Todd
>I was aware of Traz & mCPP blocking 5-HT1A, but I didn't know Nortriptyline did, I haven't seen that anywhere on the net. I think the AD abilities of Remeron would be similar to Traz & Serzone, that is, it's only an AD to a handfull of people. I like Remeron mostly as a sleep tablet, but it also is a great anti-nausea drugs & counters SRI anorgasmia. I hate that it blocks Alpha-2 NE, that effect just irritates me so much, I guess nothing is perfect. :) Ever find any data on benadryl & phenergan?
Cheers,
Panda.
Posted by zeugma on May 24, 2004, at 13:25:56
In reply to Re: wash-out before maoi, posted by King Vultan on May 24, 2004, at 8:03:25
> > >
> >
> > Trazodone, Serzone & Nortriptyline are all 5-HT2A & Alpha-1 NE blockers, I'd be interested to know which receptor blockade causes you grief. A Remeron trial could be revealing, it stands out from the other sedating AD's because it doesn't block Alpha-1 NE.
> >
> > Have you tried the other antihistamine for sleep like Phenergan & Polaramine? Phenergan might be bad, I think it would hit a bunch of receptors.
> >
> > Cheers,
> > Panda.
> >
> >
> >
>
> My theory is that it is these drugs' blockade of 5HT-1 receptors that is responsible. For trazodone I have a reference showing these Ki values in order of strength:
>
> alpha-1..... 12 +/- 0.2
> 5-HT2A..... 20 +/- 1
> 5-HT1A..... 29 +/- 1
> alpha-2..... 106 +/- 2
>
> Furthermore, the trazodone metabolite mCPP shows these Ki values:
>
> 5-HT1A..... 16 +/- 0.2
> alpha-1..... 97 +/- 3
> 5-HT2A..... 110 +/- 3
>
> So for the parent molecule, the 5-HT1A blockade is the 3rd most powerful--and of roughly the same order of magnitude as the alpha-1 blockade. For mCPP, the 5-HT1A blockade is by far the most powerful.
>
> So what does this mean? I'm not sure, but I bring it up because the 5-HT1A receptor seems like a strange one for an antidepressant to be blockading. After all, the presynaptic 5-HT1A receptor is the initial target and the postsynaptic 5-HT1A receptor is the ultimate target for SSRIs to stimulate. To me, it doesn't sound like a great idea to be blockading this receptor, but trazodone--and Serzone, which has a very similar pharmacology--obviously work as antidepressants for some people. My theory is that this weird 5-HT1A blockade business is one of the reasons these drugs are viewed by some as marginal antidepressants. I also think that someone like myself who reacts very strongly and quickly to an SSRI will have a greater chance of finding Serzone and trazodone to be disappointing.The azapirones- buspirone and gepirone- are 5-HT 1A agonists, and they are even more marginal antidepressants than trazodone and the soon to be discontinued Serzone. The azapirones have even worse pharmacokinetics than trazodone and Serzone - i.e. shorter half lives, and some people claim that this is the reason they have exhibited so little success when treating depression- or anxiety, for that matter. We will see when gepirone is released in an ER formulation, but from what I have heard buspirone ER was not a notable success.
As for nortriptyline, nobody has ever claimed it is a marginal antidepressant. So maybe for a good proprtion of people its antiserotonergetic effects are therapeutic?
>
> As for nortriptyline, I don't have statistical data, but in the receptor chart in "Psychotropic Drugs", its Ki for 5-HT1 blockade, represented by ++, is higher than most of the tricyclics, and it also has only a relatively weak blockade of serotonin reuptake to counterbalance it (its most powerful effect is its blockade of NE reuptake). I found nortriptyline to have kind of a dual action, as in one way I was getting a lift, and in another I was going down in the dumps. There was enough lift, however, that there was a net antidepressant effect.
>
> None of this appears to apply to Remeron, which my book shows has zero effect on blockading 5-HT1A receptors. I'm more optimistic that this drug would have antidepressant effects for me, but I am not enthusiastic about trying it due to possible oversedation and weight gain problems.
>
> ToddI found nortriptyline sedating enough, so I am not going near Remeron myself. The real mystery about nortriptyline is that it is the only AD with a true therapeutic window. This window cannot be based solely on its NRI effects, or adding Strattera would have resulted in loss of antidepressant effect. (?- is this reasoning off the mark? I mention it because Strattera definitely seemed to boost nortriptyline's AD effects.)
I am going to call my pdoc later and ask him to have a script called in for clomipramine. I am probably more depressed on 50 mg nortriptyline than I was on 75 mg, and sleeping worse, so i want to try the experiment of adding clomipramine and seeing if I can get a stronger AD effect from clomipramine alone than I did from nortriptyline. Then I would like to eliminate the Strattera and try a stimulant for my ADD instead.
What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
>
Posted by cybercafe on May 25, 2004, at 1:39:28
In reply to Re: I feel your pain. (Have MAOI sex question to » PhoenixGirl, posted by Questionmark on May 22, 2004, at 14:58:25
> > I wanted to ask the other people here who have taken MAOIs -- How does it affect your libido and sexual function?
>
>
> For me, and for most people, Nardil has a negative effect on libido, but Parnate has a tremendously positive effect on libido and sexual function and pleasure.2nd time around, parnate seems to have no positive effect on libido... either because of a tiny dose of abilify, ritalin, or because i actually have a couple girlfriends so sex really isn't anything i think about anymore, it's just something i do... hmmm... tough to answer
Posted by gardenergirl on May 25, 2004, at 10:00:44
In reply to Re: I feel your pain. (Have MAOI sex question to, posted by cybercafe on May 25, 2004, at 1:39:28
I had libido issues when I started on Nardil, but after about 4 months, they went away. Pleasant surprise!
gg
Posted by King Vultan on May 25, 2004, at 14:21:31
In reply to Re: wash-out before maoi » King Vultan, posted by zeugma on May 24, 2004, at 13:25:56
>
> What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
> >
>
>Clomipramine
NE reuptake............+++
5HT reuptake........+++++
DA reuptake..............+
Blockade 5HT1.........+
Blockade 5HT2.......+++
Blockade ACh.........+++
Blockade H1...........+++
Blockade alpha-1....+++
Blockade alpha-2......+
Blockade D2............++where each + represents a difference of one order of magnitude for Ki, ranging from
+++++ represents Ki = 0.1-1.0
+ represents Ki = 1000-10000
Todd
Posted by zeugma on May 25, 2004, at 18:46:57
In reply to Re: wash-out before maoi » zeugma, posted by King Vultan on May 25, 2004, at 14:21:31
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> >
> > What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
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> >
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> Clomipramine
>
> NE reuptake............+++
> 5HT reuptake........+++++
> DA reuptake..............+
> Blockade 5HT1.........+
> Blockade 5HT2.......+++
> Blockade ACh.........+++
> Blockade H1...........+++
> Blockade alpha-1....+++
> Blockade alpha-2......+
> Blockade D2............++
>
> where each + represents a difference of one order of magnitude for Ki, ranging from
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> +++++ represents Ki = 0.1-1.0
> + represents Ki = 1000-10000
>
>
> Todd
>Thank you for the info. My pdoc said I could swap nortrip for clomip one-to-one. That was a lot of my reason for wanting to try clomip instead of my lex samples in the first place. The TCA depressant/antidepressant combo (monoamine reuptake blockade vs. H1/5HT blockade) is why I think I responded to nortrip, and is the clue I will follow as i experiment with clomipramine.
By the way, do you think clomipramine + stimulant comes as close to an MAOI as is possible without actually taking one? My thought is that it might COMBINE the attributes of Parnate and Nardil. (In this comparison I would also include the GABAergic effects of the clonazepam I also take.)
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