Psycho-Babble Medication Thread 304332

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Difference between Sulpiride Amisulpride?

Posted by jparsell82 on January 22, 2004, at 18:02:13

Hi, could someone tell me how Sulpiride & Amisulpride differ? Are they the same thing, very similar? Do they have the same effects on dopamine? Thanks a lot.

 

Re: Difference between Sulpiride Amisulpride?

Posted by SLS on January 22, 2004, at 18:48:27

In reply to Difference between Sulpiride Amisulpride?, posted by jparsell82 on January 22, 2004, at 18:02:13

> Hi, could someone tell me how Sulpiride & Amisulpride differ? Are they the same thing, very similar? Do they have the same effects on dopamine? Thanks a lot.

Hi.

Sulpiride and amisulpride are chemically related and very similar clinically. Both have antidepressant properties at low dosages and antipsychotic properties at higher dosages. Amisulpride binds more tightly to dopamine D2 receptors than does sulpiride. Because of this, the dosage range for amisulpride is lower than that of sulpiride.

Which one is better for depression?

I don't know. I don't remember anyone trying both to be able to compare.

One of my doctors prefered using sulpiride. He thinks that amisulpride is more of an antipsychotic. Although there have been a few people reporting success using sulpiride on Psycho-Babble, amisulpride seems to be the more popular drug. Amisulpride is the newer of the two, and is quite a bit more expensive. However, at the low dosage used for depression, 50mg, it is still affordable.


- Scott

 

Re: Difference between Sulpiride Amisulpride? » SLS

Posted by jparsell82 on January 22, 2004, at 20:21:41

In reply to Re: Difference between Sulpiride Amisulpride?, posted by SLS on January 22, 2004, at 18:48:27

Thanks for the reply Scott. The reason I was asking is because I haven't been able to find a source for Amisulpride but have found one for Sulpiride. A couple more questions... Around what dose of Sulpiride would be equal to 50mg Amisulpride for Social Anxiety/Depression? Also, do you know if you possibly get receptor sensitivity with Amisulpride/Sulpiride such as the complaints about Mirapex?

 

Re: Difference between Sulpiride Amisulpride? » jparsell82

Posted by SLS on January 23, 2004, at 8:08:55

In reply to Re: Difference between Sulpiride Amisulpride? » SLS, posted by jparsell82 on January 22, 2004, at 20:21:41

> Thanks for the reply Scott. The reason I was asking is because I haven't been able to find a source for Amisulpride but have found one for Sulpiride. A couple more questions... Around what dose of Sulpiride would be equal to 50mg Amisulpride for Social Anxiety/Depression? Also, do you know if you possibly get receptor sensitivity with Amisulpride/Sulpiride such as the complaints about Mirapex?


I doubt that somnolence would appear after an extended trial as is observed with Mirapex. I'm sure that some dopamine receptors will upregulate in response to blockade.

I had the choice of which of the two medications to try. My doctor consulted with someone in NY who supposedly had quite a bit of experience with these drugs. He recommended sulpiride at a dosage of 50mg. That would equate to 25mg of amisulpride. I received some benefit from it during the first week, then it just sort of faded on me. It seems to me that amisulpride 50mg is the most commonly used dosage when treating depression or dysthymia.

Let us know how things go.


- Scott

 

Re: Difference between Sulpiride Amisulpride? » SLS

Posted by jerrympls on January 23, 2004, at 19:15:16

In reply to Re: Difference between Sulpiride Amisulpride? » jparsell82, posted by SLS on January 23, 2004, at 8:08:55

> > Thanks for the reply Scott. The reason I was asking is because I haven't been able to find a source for Amisulpride but have found one for Sulpiride. A couple more questions... Around what dose of Sulpiride would be equal to 50mg Amisulpride for Social Anxiety/Depression? Also, do you know if you possibly get receptor sensitivity with Amisulpride/Sulpiride such as the complaints about Mirapex?
>
>
> I doubt that somnolence would appear after an extended trial as is observed with Mirapex. I'm sure that some dopamine receptors will upregulate in response to blockade.
>
> I had the choice of which of the two medications to try. My doctor consulted with someone in NY who supposedly had quite a bit of experience with these drugs. He recommended sulpiride at a dosage of 50mg. That would equate to 25mg of amisulpride. I received some benefit from it during the first week, then it just sort of faded on me. It seems to me that amisulpride 50mg is the most commonly used dosage when treating depression or dysthymia.
>
> Let us know how things go.
>
>
> - Scott
>
>


Scott- My dr. consults with a "world famous" doc in NY as well. I wonder if it's the same one? I think his name is Dr. Andrew Neurinburg (sp?).

Jerry

 

Re: Difference between Sulpiride Amisulpride?

Posted by SLS on January 23, 2004, at 23:12:24

In reply to Re: Difference between Sulpiride Amisulpride? » SLS, posted by jerrympls on January 23, 2004, at 19:15:16


> Scott- My dr. consults with a "world famous" doc in NY as well. I wonder if it's the same one? I think his name is Dr. Andrew Neurinburg (sp?).


Hi Jerry.

Andrew Nierenberg has been one of the foremost authorities on treatment-resistant depression. He's a real nice guy. I first met him about 10 years ago. He is still on the staff of Harvard / Massachusetts General Hospital in Boston. He has also been affiliated with McLean Hospital in Belmont. What sorts of things did he suggest?


- Scott


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