Psycho-Babble Medication Thread 269696

Shown: posts 1 to 17 of 17. This is the beginning of the thread.

 

Best Antidepressant??

Posted by jms600 on October 15, 2003, at 14:32:13

Can anyone tell me, in their opinion, what they consider to be the best antidepressant drug for general moderate to severe depression?

 

Re: Best Antidepressant?? jms600

Posted by Penny on October 15, 2003, at 15:35:34

In reply to Best Antidepressant??, posted by jms600 on October 15, 2003, at 14:32:13

There is no 'best' - everyone reacts differently to each drug. It's a matter of trial and error. Of course, the general consensus of docs nowdays is to start with the SSRIs and work from there.

Good luck.
P

 

Re: Best Antidepressant?? jms600

Posted by galkeepinon on October 16, 2003, at 2:07:21

In reply to Best Antidepressant??, posted by jms600 on October 15, 2003, at 14:32:13

IMH, Celexa was very mild. My depression was 'major', I had no side effects at all from taking Celexa.
I recently started Lexapro a few months ago, and it, IMO, is a great AD.
We all react differently to antidepressants, which I'm sure you know:-)
That being the case, I don't necessarily think there is a 'best' antidepressant, it just depends on each individual.
A lot of trial and error sometimes...

> Can anyone tell me, in their opinion, what they consider to be the best antidepressant drug for general moderate to severe depression?

 

Re: Best Antidepressant??

Posted by suzie on October 16, 2003, at 9:09:11

In reply to Best Antidepressant??, posted by jms600 on October 15, 2003, at 14:32:13

I haven't found the "best" yet. Zoloft really helped my depression, but it messed up periods and caused my hair to fall out.

 

Re: Best Antidepressant?? jms600

Posted by MamaB on October 16, 2003, at 11:46:07

In reply to Re: Best Antidepressant??, posted by suzie on October 16, 2003, at 9:09:11

jms600,
The others are right, it is very much an individual thing.
I have been off and on antidepressants for nearly 20yrs, and FOR ME Wellbutrin SR (a very high dose) along with 20mgm of Celexa at bedtime. I've been on this combination for over a year and it is still working quite well.

 

Re: Best Antidepressant??

Posted by Bill LL on October 16, 2003, at 13:44:05

In reply to Best Antidepressant??, posted by jms600 on October 15, 2003, at 14:32:13

Out of the 3 I have tried; Prozac, Celexa, and for the past year Lexapro, I like Lexapro the most. But everyone is different. Effexor seems to also have a really good track record.

 

Re: Without doubt: NARDIL! (nm)

Posted by ace on October 18, 2003, at 1:25:26

In reply to Best Antidepressant??, posted by jms600 on October 15, 2003, at 14:32:13

 

Re: Without doubt: CLORGYLINE (nm)

Posted by SLS on October 18, 2003, at 9:42:23

In reply to Re: Without doubt: NARDIL! (nm), posted by ace on October 18, 2003, at 1:25:26

 

Re: Best Antidepressant?? nardil?

Posted by cybercafe on October 18, 2003, at 17:13:03

In reply to Re: Best Antidepressant?? jms600, posted by Penny on October 15, 2003, at 15:35:34

damn ace, i want to try nardil now, how long before i would start to get that happy feeling?

(yeah i'll probably stick with parnate just cuz of increased sexual function, but nardil sounds like an excellent alternative.... i ran out of benzos and anxiety is killing me)

 

Re: Without doubt: CLORGYLINE SLS

Posted by Jack Smith on October 18, 2003, at 17:28:20

In reply to Re: Without doubt: CLORGYLINE (nm), posted by SLS on October 18, 2003, at 9:42:23

Scott,

I don't want to ask but is it working for you? I haven't been here in a while due to a long-term ban and also a need to get away from this world. I would be especially happy to hear that things are going well for you.

JACK

 

Re: Without doubt: CLORGYLINE Jack Smith

Posted by SLS on October 18, 2003, at 18:02:02

In reply to Re: Without doubt: CLORGYLINE SLS, posted by Jack Smith on October 18, 2003, at 17:28:20

Hi Jack.

Thanks for your supportive sentiments.

I'm glad to know that your holiday from Psycho-Babble has been a positive one. I hate to disappoint you (and me), but I am not doing so well currently. My "loud" reference to clorgyline was meant to be a general statement. It is probably the single most efficacious antidepressant out there. For the time that I was on it, it was the only thing that was able to break through the wall and leave me slightly more responsive to other medications. No other single drug used monotherapeutically has been as helpful to me. In the past, the NIMH (National Institute of Mental Health) used clorgyline as its "ace-in-the-hole" when all else failed. Unfortunately, it is no longer manufactured for human consumption, although it is available as a biological probe in animal studies.

Clorgyline is an irreversible, selective MAO-A inhibitor. For quite a while, it was thought that it was the inhibition of the MAO-A enzyme that was most responsible for the therapeutic properties of MAOIs. That selegiline (L-deprenyl) is inferior to Nardil and Parnate in the treatment of depression would support this idea. Three drugs that I would love to see made available are clorgyline, amineptine, and nomifensine. Sometimes, I wish I were a rat.


- Scott

 

Re: Without doubt: CLORGYLINE

Posted by zeugma on October 18, 2003, at 18:21:41

In reply to Re: Without doubt: CLORGYLINE Jack Smith, posted by SLS on October 18, 2003, at 18:02:02

Scott,

I am sorry to hear you are not doing well.

I know why amineptine and nomifensine were withdrawn, but what happened with clorgyline? Was there some kind of toxicity associated with it?

 

Please Feel Better Scott! (nm) SLS

Posted by galkeepinon on October 18, 2003, at 20:05:33

In reply to Re: Without doubt: CLORGYLINE Jack Smith, posted by SLS on October 18, 2003, at 18:02:02

 

Re: Without doubt: CLORGYLINE zeugma

Posted by SLS on October 18, 2003, at 22:13:35

In reply to Re: Without doubt: CLORGYLINE, posted by zeugma on October 18, 2003, at 18:21:41

> Scott,
>
> I am sorry to hear you are not doing well.

Thanks. Better days are coming.

> I know why amineptine and nomifensine were withdrawn, but what happened with clorgyline? Was there some kind of toxicity associated with it?

Clorgyline has been around since the 1960's. For some reason, it was never actively pursued as a marketable antidepressant, although it has seen some use in clinical investigations. It was even looked at for use in ADD / ADHD. In speaking with a doctor at the NIMH, I discovered that a few people taking clorgyline died of cardiac arrest. However, this might have been nothing more than bad luck, as the number of probands was so small. Also, the dosages used in early investigations were two high. 15mg is about as high as one would need to go, and they were using 30mg on children. The patent on clorgyline must surely have expired by now, and there is too little demand for MAO inhibitors to encourage a drug company to bring it to market. If it were out there, I would be taking it right now and combining it with a tricyclic.

For now, I have my fingers crossed that my recent addition of Remeron to a combination including imipramine and Effexor will bear fruit.


- Scott

 

Re: Best Antidepressant?? jms600 RVP

Posted by Ramon Paz on October 19, 2003, at 7:05:04

In reply to Re: Best Antidepressant?? jms600, posted by MamaB on October 16, 2003, at 11:46:07

Yes, I like both bupropion and amineptinethe better ones. Amineptine to do in cycles cause every time you stop some time(no withdrall if taking bupropion), then you take again, it let you VERY, VERYYYYYYYYY nice for determinated time.depending how you use and what else are you taking.
Can you say me how much wellbutrin you take dayly? and the SSRI I on paxil, but would think to change by milnacipran or lexapro (maybe plus remeron). Say me your thoughts.
Tanks.
RVP.

 

Re: Without doubt: CLORGYLINE SLS

Posted by zeugma on October 19, 2003, at 11:47:54

In reply to Re: Without doubt: CLORGYLINE zeugma, posted by SLS on October 18, 2003, at 22:13:35

> > Scott,
> >
> > I am sorry to hear you are not doing well.
>
> Thanks. Better days are coming.
>
> > I know why amineptine and nomifensine were withdrawn, but what happened with clorgyline? Was there some kind of toxicity associated with it?
>
> Clorgyline has been around since the 1960's. For some reason, it was never actively pursued as a marketable antidepressant, although it has seen some use in clinical investigations. It was even looked at for use in ADD / ADHD. In speaking with a doctor at the NIMH, I discovered that a few people taking clorgyline died of cardiac arrest. However, this might have been nothing more than bad luck, as the number of probands was so small. Also, the dosages used in early investigations were two high. 15mg is about as high as one would need to go, and they were using 30mg on children. The patent on clorgyline must surely have expired by now, and there is too little demand for MAO inhibitors to encourage a drug company to bring it to market. If it were out there, I would be taking it right now and combining it with a tricyclic.

I've seen clorgyline mentioned in some of the literature on ADD. I think pargyline was also used- that's a MAO-B inhibitor right? The names are similar, I might be confusing them. I suspected that it was at least in part the MAOI stigma that led to its withdrawal, similar to what happened to Marplan. Sometimes I think the treatment of depression has actually regressed over the last 30 years.
>
> For now, I have my fingers crossed that my recent addition of Remeron to a combination including imipramine and Effexor will bear fruit.
>
> I hope the 'California rocket fuel' lives up to its name and blasts you into a stable orbit, emotionally speaking!


> - Scott

z

 

Re: Best Antidepressant?? Hey, MammaB!!!

Posted by Ramon Paz on October 19, 2003, at 19:57:30

In reply to Re: Best Antidepressant?? jms600, posted by MamaB on October 16, 2003, at 11:46:07

> jms600,
> The others are right, it is very much an individual thing.
> I have been off and on antidepressants for nearly 20yrs, and FOR ME Wellbutrin SR (a very high dose) along with 20mgm of Celexa at bedtime. I've been on this combination for over a year and it is still working quite well.

I already posted to you a question. As I really like welbutrin, I would like how much is this "very high dose" you say.
Answer me ASAP before my next pDoc consult.
Tanks, RVP.


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