Psycho-Babble Medication Thread 240334

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Strattera and Wellbutrin - what's the difference?

Posted by DiscoPuppy on July 9, 2003, at 15:37:33

Looking at the actions of Strattera and Wellbutrin, it seems very similar to me. They are both considered to be a SNRI.

So what's the difference?

 

Good question... (nm)

Posted by Penny on July 9, 2003, at 15:54:58

In reply to Strattera and Wellbutrin - what's the difference?, posted by DiscoPuppy on July 9, 2003, at 15:37:33

 

Re: Strattera and Wellbutrin - what's the difference?

Posted by zeugma on July 9, 2003, at 21:01:13

In reply to Strattera and Wellbutrin - what's the difference?, posted by DiscoPuppy on July 9, 2003, at 15:37:33

> Looking at the actions of Strattera and Wellbutrin, it seems very similar to me. They are both considered to be a SNRI.
>
> So what's the difference?


Strattera is a selective norepinephrine reuptake inhibitor, no doubt about it.

Wellbutrin is... well, I don't think anyone knows what Wellbutrin does anymore. Check out this link

http://www.acnp.org/g5/p/SCH79_1139-164.pdf


for the latest on Wellbutrin's mechanism of action, basically unknown at this point.


Speaking anecdotally, the norepinephrine reuptake inhibors Strattera and nortriptyline have been of great benefit to me, while I didn't last three days on Wellbutrin. I think it's safe to say at this point that it's anything BUT a norepinephrine reuptake inhibitor, and hence has little in common with Strattera.

 

this is the link

Posted by zeugma on July 9, 2003, at 21:06:02

In reply to Re: Strattera and Wellbutrin - what's the difference?, posted by zeugma on July 9, 2003, at 21:01:13

http://www.acnp.org/g5/p/SCH79_1139-1164.pdf

 

Re: Strattera and Wellbutrin - what's the differen DiscoPuppy

Posted by Viridis on July 10, 2003, at 7:25:58

In reply to Strattera and Wellbutrin - what's the difference?, posted by DiscoPuppy on July 9, 2003, at 15:37:33

Wellbutrin drove me up the wall, with very unpleasant side effects. I was apprehensive about taking Strattera because of its mechanism of action, given my reaction to WB. But my pdoc said that in his experience, people seem to react very differently to Strattera than WB, and that WB has numerous, only vaguely understood actions on other neurotransmitters that may explain its side effects for some (like me).

Having used Strattera for a short while now, I agree that it's very different. It has a calming, focusing effect for me, and I'm very enthusiastic about it. I did have some mild side effects (nausea etc.), but those disappeared very quickly. If you try it, just be careful with dosage increases, and go up fairly slowly.

 

Re: Strattera and Wellbutrin - what's the differen

Posted by CC67 on July 12, 2003, at 5:47:21

In reply to Re: Strattera and Wellbutrin - what's the differen DiscoPuppy, posted by Viridis on July 10, 2003, at 7:25:58

Wellbutrin also works on dopamine,actually
strattera appears to be more selective.
Meaning,"selective norepinephrine reuptake inhibitor"
Wellbutrin,is a "weak inhibitor of nueronaluptake
on norepinephrine,serotonin and dopamine."


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