Psycho-Babble Medication Thread 239530

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MMMM... morphine

Posted by Caleb462 on July 7, 2003, at 0:06:40

In reply to Morphine is great, but watch the constipation!!! (nm) Ame Sans Vie, posted by MB on July 6, 2003, at 12:01:17

*drools*, heavily.

I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.

 

Ah, come on! Caleb462

Posted by MB on July 7, 2003, at 14:04:36

In reply to MMMM... morphine, posted by Caleb462 on July 7, 2003, at 0:06:40

> *drools*, heavily.
>
> I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.

Ah, come on. Is it better to have loved and lost than never to have loved at all? I was just thinking today, how wonderful it is to know that if things ever get too bad...if they keep getting worse, I can always go back to shooting heroin. I can even top myself with it, no problem. I've overdosed before, and trust me, it is no big deal. I just drifted off into the most blissful never-never land. I was almost angry to be awakened by my friend pounding the crap out of me.

MB

 

Re: Ah, come on!

Posted by Caleb462 on July 7, 2003, at 23:26:32

In reply to Ah, come on! Caleb462, posted by MB on July 7, 2003, at 14:04:36

> > *drools*, heavily.
> >
> > I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.
>
> Ah, come on. Is it better to have loved and lost than never to have loved at all? I was just thinking today, how wonderful it is to know that if things ever get too bad...if they keep getting worse, I can always go back to shooting heroin. I can even top myself with it, no problem. I've overdosed before, and trust me, it is no big deal. I just drifted off into the most blissful never-never land. I was almost angry to be awakened by my friend pounding the crap out of me.
>
> MB
>

lol... trust me, if diacetylmorphine was a legal substance - I'd be all over that shit. However, with the insane "war on drugs" going on and all, being a heroin addict is not the safest or easiest thing to do.

 

Re: Ah, come on!

Posted by djmmm on July 8, 2003, at 8:17:06

In reply to Re: Ah, come on!, posted by Caleb462 on July 7, 2003, at 23:26:32

> > > *drools*, heavily.
> > >
> > > I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.
> >
> > Ah, come on. Is it better to have loved and lost than never to have loved at all? I was just thinking today, how wonderful it is to know that if things ever get too bad...if they keep getting worse, I can always go back to shooting heroin. I can even top myself with it, no problem. I've overdosed before, and trust me, it is no big deal. I just drifted off into the most blissful never-never land. I was almost angry to be awakened by my friend pounding the crap out of me.
> >
> > MB
> >
>
> lol... trust me, if diacetylmorphine was a legal substance - I'd be all over that shit. However, with the insane "war on drugs" going on and all, being a heroin addict is not the safest or easiest thing to do.

some interesting heroin info:
http://opioids.com/heroin/heroinhistory.html

 

Re: MMMM... morphine Caleb462

Posted by KimberlyDi on July 8, 2003, at 8:34:00

In reply to MMMM... morphine, posted by Caleb462 on July 7, 2003, at 0:06:40

> *drools*, heavily.
>
> I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.


Try a cocktail of morphine & a C-section. You wouldn't be drooling anymore. :) Kim

 

Heinrich Dreser and facination with acetylation. djmmm

Posted by MB on July 8, 2003, at 10:59:42

In reply to Re: Ah, come on!, posted by djmmm on July 8, 2003, at 8:17:06

I guess Heinrich Dreser loved to stick acetyl groups on molecules. He came up with aspirin by adding an acetyl group to salicylic acid (yielding a more tolorable side effect profile) and he came up with heroin by acetylating morphine. It's kind of funny when you think about it...two major sucesses (well, maybe heroin was a *little* bit of a problem child, but it *did* work) by simply acetylating already useful medications.

MB

 

Re: MMMM... morphine KimberlyDi

Posted by MB on July 8, 2003, at 11:01:49

In reply to Re: MMMM... morphine Caleb462, posted by KimberlyDi on July 8, 2003, at 8:34:00

> > *drools*, heavily.
> >
> > I curse myself for ever tasting the family of forbidden fruits that is the opiates/opiods.
>
>
> Try a cocktail of morphine & a C-section. You wouldn't be drooling anymore. :) Kim


I bet you would drool (before passing out) if you had a C-section *without* the morphine.

morbidly yours,
MB


 

Also interesting that aspirin comes up today djmmm

Posted by MB on July 8, 2003, at 11:13:34

In reply to Re: Ah, come on!, posted by djmmm on July 8, 2003, at 8:17:06

As, I accidently OD's on it last night. I had been taking about 5 gm a day for the past three days when late last night I went deaf with the worst tinnitus. See, on these meds, I'm such an apathetic sloth that the only way I can function is to smoke myself to death. I never smoked until three months ago, but in those three months, I've smoked what feels like two ulcers in my lower esophagus (very painful...food gets caught on them, etc, and I can't see them with a flashlight: too low; you'd need an endoscope). Anyway, 1gm of aspirin every 3-4 hours seems to take the edge off, but I guess aspirin is what they call "ototoxic" (I researched it last night). It can give you tinnitus, and sometimes make you go deaf. I thought it was gone when I got up this morning, but after talking on the phone, it has come back. DAMN!!!

MB

It's all Heinrich Dreser's fault!

 

Re: Laudanum--the greatest thing I've tried yet!!!

Posted by samplemethod on July 8, 2003, at 13:55:39

In reply to Laudanum--the greatest thing I've tried yet!!!, posted by Ame Sans Vie on July 5, 2003, at 15:07:11

HOw do u know if you have irritable bowel syndrome... can ya fake it?

hehe


> I was prescribed 16oz of this today for IBS (they actually call it DTO-deodorized tincture of opium, nowadays), and was instructed to take 1-2ml q.i.d. Well, of course I started off with the higher-end dose, lol. And while I know 2ml of laudanum "only" contains 20mg anhydrous morphine, I must say this stuff is wonderful! I think I'll stick to the Immodium for the IBS and save this stuff for when I really need it, lol.

 

Re: Laudanum--the greatest thing I've tried yet!!!

Posted by Ame Sans Vie on July 8, 2003, at 20:08:01

In reply to Re: Laudanum--the greatest thing I've tried yet!!!, posted by samplemethod on July 8, 2003, at 13:55:39

> HOw do u know if you have irritable bowel syndrome... can ya fake it?
>
> hehe


lol, actually, come to think of it, it would be a pretty easy disorder to fake... the diagnosis of it is based pretty much only on excluding all other possibilities, since it's not known what causes IBS. Usually they're run a battery of tests (blood work, sigmoidoscopy, stool sample, and colon biopsy being the most common) and if nothing comes up that would indicate an inflammatory bowel disease, Crohn's, etc etc, then IBS is generally the diagnosis they give you.

 

Re: Laudanum--the greatest thing I've tried yet!!! Ame Sans Vie

Posted by Jack Smith on July 8, 2003, at 20:48:22

In reply to Laudanum--the greatest thing I've tried yet!!!, posted by Ame Sans Vie on July 5, 2003, at 15:07:11

In the few months I have posted on this board, I have heard you list the following drugs as the greatest things you have ever tried

1. Provigil
2. Lexapro
3. Mirapex
4. Laudanum

I'm not trying to knock you but I wonder if you might be bipolar? Specifically because you seem to get really euphoric on drugs and then it wears off and you move on to the next thing. Just curious.

JACK

 

Re: Laudanum--the greatest thing I've tried yet!!!

Posted by Ame Sans Vie on July 8, 2003, at 20:55:59

In reply to Re: Laudanum--the greatest thing I've tried yet!!! Ame Sans Vie, posted by Jack Smith on July 8, 2003, at 20:48:22

> In the few months I have posted on this board, I have heard you list the following drugs as the greatest things you have ever tried
>
> 1. Provigil

Sure, it worked great at 1,000mg a day, but the horrible headaches that ensued after a few days using it this way made it prohibitive.

> 2. Lexapro

Worked great, but I just couldn't deal with the sexual dysfunction. At first I thought I could tough it out, and the Mirapex reversed it somewhat, but all in all I think my exaggerated response to Lexapro was due to a lot of really good things going on in my life at the time.

> 3. Mirapex

Still works great; thinking of sticking with it, but only if I can find something that will get rid of the hypersomnolence it causes.

> 4. Laudanum

lol, well I wasn't speaking of it as a psych drug to be taken on a regular basis. I mean, it's morphine, for chrissakes. But yeah, it sure does beat anything else I've ever tried.

> I'm not trying to knock you but I wonder if you might be bipolar? Specifically because you seem to get really euphoric on drugs and then it wears off and you move on to the next thing. Just curious.
>
> JACK

Definitely not bipolar... I'm rarely depressed, and when I am, it's purely situational. And I can't say I've ever felt genuinely "euphoric" on drugs... perhaps just an overwhelming sense of relief and contentment that my anxiety was under control!

 

Re: blocked for 2 weeks Caleb462

Posted by Dr. Bob on July 8, 2003, at 22:16:55

In reply to Re: Ah, come on!, posted by Caleb462 on July 7, 2003, at 23:26:32

> trust me, if diacetylmorphine was a legal substance - I'd be all over that sh*t.

Sorry to be such a prude, but I've asked you before not to use language that could offend others, and the last time you were blocked it was for 1 week, so this time I'm going to make it for 2.

Bob

PS: Follow-ups regarding posting policies should be redirected to Psycho-Babble Administration.

 

aspirin and serotonin, and also opiods

Posted by avid abulia on July 12, 2003, at 21:47:05

In reply to Re: blocked for 2 weeks Caleb462, posted by Dr. Bob on July 8, 2003, at 22:16:55

Hey, you guys are mostly a lot smarter than me here, but i've never seen this posted here, so i thought that perhaps i would tell you guys that salicylates (including aspirin) are inducers of tryptophan hydroxylase, the rate-limiting factor in the production of serotonin. It is occasionally successful in treating Tourette's syndrome, for that reason, and one well-respected expert on Tourette's, Dr. David Comings, published in his authoritative tome "Tourette's Syndrome and Human Behaviour" that his first recommendation to all new patients is to try taking two aspirin in the morning to see if that controls symptoms.

When used for this purpose, it is (according to his book) useful primarily in children... which would cause some very serious potential risks... but as i assume few on this list are children young enough to develop Reye's syndrome, that wouldn't be such an issue and you might try talking to your doctors about it if you want an augmentation strategy for serotonin synthesis.

So far as opiods go--i'm not a fan myself, i think mainly because i've used them for very severe pain (basilar migraines) in the past, but some people do quite well on them, and i'm not one to knock another's drug. And, incidentally, chronic (but not acute) morphine ingestation has been shown to induce tryptophan hydroxlyase as well... but, sticking to more practically relevant
info here (i can just see it... "Doc, I'm depressed... I hear morphine might do me some good, though." "Uh-huh... well, I'm not that kind of doctor. You might try that old croaker down the road with a forged medical license, though.")... well, tramadol (a codeine analog with low affinity for mu-opiod receptors and serotonin and noradrenaline reuptake inhibitory properties) has recently been shown in several clinically trials in several different countries to be an effective, rapid-onset antidepressant for some people, and... I think it was in Australia, if i remember right... it is currently going through the approval process to treat depression, obsessive-compulsive disorder, and Tourette's syndrome. Unlike morphine, tramadol has very low abuse potential, and shows no immuno-suppressive effects. In fact, it actually enhances natural killer cell function.

~AA

 

Re: aspirin and serotonin, and also opiods avid abulia

Posted by Larry Hoover on July 13, 2003, at 7:16:11

In reply to aspirin and serotonin, and also opiods, posted by avid abulia on July 12, 2003, at 21:47:05

> Hey, you guys are mostly a lot smarter than me here, but i've never seen this posted here, so i thought that perhaps i would tell you guys that salicylates (including aspirin) are inducers of tryptophan hydroxylase, the rate-limiting factor in the production of serotonin. It is occasionally successful in treating Tourette's syndrome, for that reason, and one well-respected expert on Tourette's, Dr. David Comings, published in his authoritative tome "Tourette's Syndrome and Human Behaviour" that his first recommendation to all new patients is to try taking two aspirin in the morning to see if that controls symptoms.

That's fascinating. I didn't know that. Thanks.

> So far as opiods go--i'm not a fan myself, i think mainly because i've used them for very severe pain (basilar migraines) in the past, but some people do quite well on them, and i'm not one to knock another's drug. And, incidentally, chronic (but not acute) morphine ingestation has been shown to induce tryptophan hydroxlyase as well... but, sticking to more practically relevant
> info here (i can just see it... "Doc, I'm depressed... I hear morphine might do me some good, though." "Uh-huh... well, I'm not that kind of doctor. You might try that old croaker down the road with a forged medical license, though.")... well, tramadol (a codeine analog with low affinity for mu-opiod receptors and serotonin and noradrenaline reuptake inhibitory properties) has recently been shown in several clinically trials in several different countries to be an effective, rapid-onset antidepressant for some people, and... I think it was in Australia, if i remember right... it is currently going through the approval process to treat depression, obsessive-compulsive disorder, and Tourette's syndrome. Unlike morphine, tramadol has very low abuse potential, and shows no immuno-suppressive effects. In fact, it actually enhances natural killer cell function.
>
> ~AA

About tramadol....

Yes, I've seen some reports of these trials, but I've never found anyone who used tramadol, and had a lasting benefit.

The rapid-onset antidepressant effect is quite startling. Hours. But use it every day, and the antidepressant effect diminishes, perhaps over two weeks. That's my experience, and the experience of everyone I've ever talked to, who tried it.

Bottom line, it may serve as an augmentative, or a "tweaker", but only for short-term benefit. That's anecdotal, of course, but I've never found anyone who could achieve long-term benefit from tramadol, buprenorphine, or any other semi-synthetic opiate antidepressants.

Lar

 

Re: aspirin and serotonin, and also opiods

Posted by samplemethod on July 13, 2003, at 11:53:20

In reply to Re: aspirin and serotonin, and also opiods avid abulia, posted by Larry Hoover on July 13, 2003, at 7:16:11

Hey,

hmmm so would you suggest to have aspirin regularly. Has anyone found any trials, journal articles or tests that would suggest we should include it into our diets regularly.

If so I think there would be alot of people on these boards adding aspirin to their daily regimen.

I cant tell you that when I have aspirin.. just one tablet it really hurts my stomach.

Would that suggest I have something wrong with me?? Or that I should take such and such a supplement

Oh australia hey... Ive actually been interested in tramadol in the past but more for occasional use.

cheers for the info guys....u all do a great job


> > Hey, you guys are mostly a lot smarter than me here, but i've never seen this posted here, so i thought that perhaps i would tell you guys that salicylates (including aspirin) are inducers of tryptophan hydroxylase, the rate-limiting factor in the production of serotonin. It is occasionally successful in treating Tourette's syndrome, for that reason, and one well-respected expert on Tourette's, Dr. David Comings, published in his authoritative tome "Tourette's Syndrome and Human Behaviour" that his first recommendation to all new patients is to try taking two aspirin in the morning to see if that controls symptoms.
>
> That's fascinating. I didn't know that. Thanks.
>
> > So far as opiods go--i'm not a fan myself, i think mainly because i've used them for very severe pain (basilar migraines) in the past, but some people do quite well on them, and i'm not one to knock another's drug. And, incidentally, chronic (but not acute) morphine ingestation has been shown to induce tryptophan hydroxlyase as well... but, sticking to more practically relevant
> > info here (i can just see it... "Doc, I'm depressed... I hear morphine might do me some good, though." "Uh-huh... well, I'm not that kind of doctor. You might try that old croaker down the road with a forged medical license, though.")... well, tramadol (a codeine analog with low affinity for mu-opiod receptors and serotonin and noradrenaline reuptake inhibitory properties) has recently been shown in several clinically trials in several different countries to be an effective, rapid-onset antidepressant for some people, and... I think it was in Australia, if i remember right... it is currently going through the approval process to treat depression, obsessive-compulsive disorder, and Tourette's syndrome. Unlike morphine, tramadol has very low abuse potential, and shows no immuno-suppressive effects. In fact, it actually enhances natural killer cell function.
> >
> > ~AA
>
> About tramadol....
>
> Yes, I've seen some reports of these trials, but I've never found anyone who used tramadol, and had a lasting benefit.
>
> The rapid-onset antidepressant effect is quite startling. Hours. But use it every day, and the antidepressant effect diminishes, perhaps over two weeks. That's my experience, and the experience of everyone I've ever talked to, who tried it.
>
> Bottom line, it may serve as an augmentative, or a "tweaker", but only for short-term benefit. That's anecdotal, of course, but I've never found anyone who could achieve long-term benefit from tramadol, buprenorphine, or any other semi-synthetic opiate antidepressants.
>
> Lar
>
>

 

Re: aspirin and serotonin, and also opiods Larry Hoover

Posted by avid abulia on July 13, 2003, at 15:28:12

In reply to Re: aspirin and serotonin, and also opiods avid abulia, posted by Larry Hoover on July 13, 2003, at 7:16:11

>
> About tramadol....
>
> Yes, I've seen some reports of these trials, but I've never found anyone who used tramadol, and had a lasting benefit.
>
> The rapid-onset antidepressant effect is quite startling. Hours. But use it every day, and the antidepressant effect diminishes, perhaps over two weeks. That's my experience, and the experience of everyone I've ever talked to, who tried it.
>

Yes, that has been my experience on it as well. i have a bottle of the stuff around here somewhere, i occasionally use it for a PRN anti-depressant effects, for no more than three times per day for a few days at a time because it does wear off pretty quickly. But it does faff-all for pain, for me, though.

I have heard anecdotal stories from friends of mine who are heavy into junk that heroin (which, being that it is turned into morphine within 4 minutes of entering the bloodstream, induces tryptophan hydroxylase) has anti-depressant effects... but how much of that is due to the multifarious social as well as physiological effects of addiction to an illegal opiod that one self-injects, i can only guess at.

~AA

 

Re: aspirin and serotonin, and also opiods

Posted by avid abulia on July 13, 2003, at 15:40:22

In reply to Re: aspirin and serotonin, and also opiods, posted by samplemethod on July 13, 2003, at 11:53:20

> Hey,
>
> hmmm so would you suggest to have aspirin regularly. Has anyone found any trials, journal articles or tests that would suggest we should include it into our diets regularly.
>
>

I wouldn't suggest aspirin unless you talk to your doctor about it first, it is pretty safe but long-term ingestion of anything can have deleterious effects and you should be evaluated for contraindications. And i am not personally aware of any studies of efficacy as an add-on for depression, i only know that it induces tryptophan hydroxylase and there is anecdotal support for use in Tourette's syndrome, but my information is old. There is, however, some support for the use of add-on low-dose phenothiazines for depression, and those are (among so many other things) inducers of tryptophan hydroxylase.

>
>
> If so I think there would be alot of people on these boards adding aspirin to their daily regimen.
>
> I cant tell you that when I have aspirin.. just one tablet it really hurts my stomach.
>
> Would that suggest I have something wrong with me?? Or that I should take such and such a supplement
>
>

No, it does that to a lot of people... i know that the mechanism of action for causing stomach pain and increased risk of ulcer is because of COX-1 inhibition causing decreased secretion of stomach mucous, and i know that there is a supplement that helps that, but as it is not a problem for me personally and i have the usual anoretic-anemic memory problems i can't recall just off the top of my head what it was. I'm thinking it might have been SAMe, though if you are interested you should do your own research.

>
>
> Oh australia hey... Ive actually been interested in tramadol in the past but more for occasional use.
>
> cheers for the info guys....u all do a great job
>

 

Re: aspirin and serotonin, and also opiods

Posted by SLS on July 14, 2003, at 7:05:54

In reply to Re: aspirin and serotonin, and also opiods avid abulia, posted by Larry Hoover on July 13, 2003, at 7:16:11

Hi.

> Bottom line, it may serve as an augmentative, or a "tweaker", but only for short-term benefit. That's anecdotal, of course, but I've never found anyone who could achieve long-term benefit from tramadol, buprenorphine, or any other semi-synthetic opiate antidepressants.

There have been two long-time posters on PB who have had long-term success treating severe depression with oxycodone, buprenorphine, and methadone. Both people demonstrated themselves to be accurate reporters in my opinion.


- Scott

 

Re: aspirin and serotonin, and also opiods

Posted by stjames on July 17, 2003, at 16:07:53

In reply to Re: aspirin and serotonin, and also opiods, posted by SLS on July 14, 2003, at 7:05:54

> Hi.
>
> > Bottom line, it may serve as an augmentative, or a "tweaker", but only for short-term benefit. That's anecdotal, of course, but I've never found anyone who could achieve long-term benefit from tramadol, buprenorphine, or any other semi-synthetic opiate antidepressants.

Lar,

Keep looking. These folks are reported in the literature and on this site.

 

Re: aspirin and serotonin, and also opiods Larry Hoover

Posted by samplemethod on July 21, 2003, at 8:24:49

In reply to Re: aspirin and serotonin, and also opiods avid abulia, posted by Larry Hoover on July 13, 2003, at 7:16:11

Hey Lar have you found anything interesting on aspirin related to serotonin lately?

cheers


> > Hey, you guys are mostly a lot smarter than me here, but i've never seen this posted here, so i thought that perhaps i would tell you guys that salicylates (including aspirin) are inducers of tryptophan hydroxylase, the rate-limiting factor in the production of serotonin. It is occasionally successful in treating Tourette's syndrome, for that reason, and one well-respected expert on Tourette's, Dr. David Comings, published in his authoritative tome "Tourette's Syndrome and Human Behaviour" that his first recommendation to all new patients is to try taking two aspirin in the morning to see if that controls symptoms.
>
> That's fascinating. I didn't know that. Thanks.
>

 

Re: aspirin and serotonin, and also opiods samplemethod

Posted by Larry Hoover on July 23, 2003, at 7:39:11

In reply to Re: aspirin and serotonin, and also opiods Larry Hoover, posted by samplemethod on July 21, 2003, at 8:24:49

> Hey Lar have you found anything interesting on aspirin related to serotonin lately?
>
> cheers

I've been exceedingly busy.....home 14 hours in the last nine days....

Tell you what.....bring this up again the end of next week, as a reminder for me.

Lar

 

Re: aspirin and serotonin, and also opiods

Posted by samplemethod on July 25, 2003, at 15:24:22

In reply to Re: aspirin and serotonin, and also opiods samplemethod, posted by Larry Hoover on July 23, 2003, at 7:39:11

ok will do

cheers and good luck with your work


> > Hey Lar have you found anything interesting on aspirin related to serotonin lately?
> >
> > cheers
>
> I've been exceedingly busy.....home 14 hours in the last nine days....
>
> Tell you what.....bring this up again the end of next week, as a reminder for me.
>
> Lar

 

Re: aspirin and serotonin, and also opiods samplemethod

Posted by Larry Hoover on July 26, 2003, at 12:27:06

In reply to Re: aspirin and serotonin, and also opiods Larry Hoover, posted by samplemethod on July 21, 2003, at 8:24:49

> Hey Lar have you found anything interesting on aspirin related to serotonin lately?
>
> cheers

Frankly, it's hard to find articles which discuss aspirin's effects in the brain which are also understandable by anyone other than super-geek medical-researcher types. I found one abstract which is fairly easily understood. Nociception is the perception of pain, so antinociceptive implies blocking of pain. 400 mg/kg is a huge dose of aspirin, by the way, equivalent to 86 regular aspirin tablets (325 mg size) consumed by the "standard" 70 kg (154 lb.) human.

It's anyone's guess if this effect is also seen in humans, at the more normal dose of aspirin. That said, addiction to aspirin is a recognized phenomenon.

Lar

Pharmacology. 1997 Feb;54(2):84-91.

Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid.

Pini LA, Vitale G, Sandrini M.

Department of Internal Medicine, University of Modena, Italy.

Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test. ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT2 receptors in cortical brain membranes 30 min after drug administration. Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2 receptors in cortical membranes induced by ASA. The serum salicylate concentrations were not affected by pretreatment with naloxone. These data indicate a central antinociceptive activity of ASA and suggest that ASA may exert its antinociceptive action through serotonergic and opiatergic pathways.

 

Re: aspirin and serotonin, and also opiods Larry Hoover

Posted by noa on July 26, 2003, at 18:19:34

In reply to Re: aspirin and serotonin, and also opiods samplemethod, posted by Larry Hoover on July 26, 2003, at 12:27:06

Interesting, Larry.

If aspirin reduces the cortical 5HT2 receptors, I wonder if it could have an effect on the motor activation from serotonergic meds (one of my pet peeves).
And, of course then I wonder if the reduction of 5HT2 receptors in this study would happen at anything but megadoses.
Caviat: I sound like I know more about neurotransmitters and receptors than I really do!


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