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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 86 to 110 of 1242. Go back in thread:
Posted by tia on January 18, 2003, at 17:09:31
In reply to Re: Straterra - No other takers?, posted by jodie on January 17, 2003, at 23:49:53
I started my second day on straterra taking 40mg. I dont know if its in my head or what but i feel like the anxiety is back again. I think its just the medicine change, because it says on the package sheet that it is one of the side effects so i hope it goes away. I am not giving up yet. I havent had to many dry things, just my mouth. I drink lots of water so its not to bad. I do have a lot of energy but this afternoon i had to lay down for awhile i just felt like my body needed some rest. It could be from the anafranil i take at night.
I am not sure how long the wellburtrin takes to get out of my system so i am sure the two medicines are clashing.
I will let you all know how tomorrow goes.
Bye!
Tia
Posted by BekkaH on January 18, 2003, at 21:44:17
In reply to Re: Straterra -Second Day, posted by tia on January 18, 2003, at 17:09:31
>I dont know if its in my head or what but i feel >like the anxiety is back again. I think its just >the medicine change, because it says on the >package sheet that it is one of the side effects >so i hope it goes away. I am not giving up yet.
> I am not sure how long the wellburtrin takes to >get out of my system so i am sure the two >medicines are clashing.
**********************************************
Regarding Wellbutrin: The AVERAGE half-life of bupropion (the generic name of Wellbutrin) is about 14 hours; HOWEVER, bupropion has several metabolites (substances it is broken down into in the body) that have much longer half-lives. I don't have the exact numbers in front of me at the moment, but if I remember correctly, one of the metabolites has an average half-life of approximately 37 hours. Since these are averages, there is a wide range that can vary according to a number of factors, including concomitant medications and the liver's ability to metabolize the medications. As you probably know, the half-life is the time it takes for HALF of the substance to leave your body. I don't know how Strattera interacts with Wellbutrin, but since they both block the reuptake of norepinephrine, which can cause anxiety, I believe the likelihood of each one potentiating the other's anxiogenic effects is quite high. I hope you do well on Strattera. Medicines like this are long overdue.
Posted by Jim Boardman on January 19, 2003, at 10:02:33
WEEK THREE STRATERRA: Just visited my pdoc last Wednesday. He has asked me to reduce the dose of Straterra to 40 mg per day to see if some of the side effects taper off. He gave me a full script, but wants me to try the lesser dose. He didn't change the lexapro, remeron or gabitril. I still feel good after three days of the reduction. Not quite as high, but good. I'll keep you posted.
Posted by zenclear on January 19, 2003, at 11:45:10
In reply to Straterra after three weeks, posted by Jim Boardman on January 19, 2003, at 10:02:33
> WEEK THREE STRATERRA: Just visited my pdoc last Wednesday. He has asked me to reduce the dose of Straterra to 40 mg per day to see if some of the side effects taper off. He gave me a full script, but wants me to try the lesser dose. He didn't change the lexapro, remeron or gabitril. I still feel good after three days of the reduction. Not quite as high, but good. I'll keep you posted.
What side effects at 3 weeks? Thanks for your updates!
Posted by hildi on January 19, 2003, at 11:51:01
In reply to Re: Straterra after three weeks » Jim Boardman, posted by zenclear on January 19, 2003, at 11:45:10
Posted by BekkaH on January 19, 2003, at 12:06:30
In reply to Straterra after three weeks, posted by Jim Boardman on January 19, 2003, at 10:02:33
Since Strattera is so new and there are so few threads on it, is it possible for this new Strattera thread to be attached to the one above (i.e., the one with Jim Boardman's other posts)?
Posted by Peter S. on January 19, 2003, at 13:15:51
In reply to Dr. Bob, can this thread be attached to one above?, posted by BekkaH on January 19, 2003, at 12:06:30
I took my first dose (40mg) of Straterra this am. An hour later I threw it up. I'm not sure what to do. Maybe I'll try dividing the doses over the day. Does anyone know if your stomach eventually adapts to a particular drug? Any other ideas? I know people on chemotherapy deal with this kind of thing.
I'm out of options and I'm determined to try Straterra.
Peter S.
Posted by BekkaH on January 19, 2003, at 13:34:32
In reply to STRATERRA- Throwing up, posted by Peter S. on January 19, 2003, at 13:15:51
Could you ask your doctor to prescribe it in a much lower strength? 40mg seems like a very high starting dose. I read that it is available in much lower strengths, like 10, 18 and 25 mg. Lilly has a website for Strattera at http://www.strattera.com. The PDF contains a lot of useful information.
Posted by BekkaH on January 19, 2003, at 13:48:56
In reply to Re: STRATERRA- Throwing up - Peter, posted by BekkaH on January 19, 2003, at 13:34:32
Peter,
The PDF is accessed by clicking on the Prescribing Information link on the website I mentioned above. If you go to the website, then click on Home, then scroll down to the bottom of the photograph, you will see the link for prescribing information. I hope you feel better soon.
Posted by Peter S. on January 19, 2003, at 14:26:30
In reply to Prescribing Information, posted by BekkaH on January 19, 2003, at 13:48:56
Thanks for the link Bekka
It looks like vomiting is a somewhat common side effect. I'm going to try reducing the dose to 10mg- hopefully I'll start adjusting to it and I can work my way up.
Posted by Dr. Bob on January 19, 2003, at 18:53:57
In reply to Dr. Bob, can this thread be attached to one above?, posted by BekkaH on January 19, 2003, at 12:06:30
> is it possible for this new Strattera thread to be attached to the one above
Jim,
Would that be OK with you?
Bob
Posted by jodie on January 19, 2003, at 19:51:40
In reply to Re: Straterra -Second Day -tia, posted by BekkaH on January 18, 2003, at 21:44:17
Well I've been on Strattera for several days now. Yesterday I started breaking out with little red itchy bumps on my legs. It spread to my arms, back, belly, chest, and neck. Today the rash started getting worse. It was burning and itching so bad, I was going insane. I finally went to the ER, they believe it was a delayed allergic reaction to the Strattera. They gave me shots of benadryl, epinepherine, and a steroid. My face is also getting a little puffy. They released me with a prescription of Medrol Pak ( a steroid), and told me to take benadryl on a regular basis. I haven't taken any other meds that could have caused it. I took the sample bottle of strattera with the paper insert to the ER with me. The Dr. looked it over. They do believe the Strattera caused this. I still have a horrible rash. I itch, but the meds have helped a little. They told me to stop taking my strattera, and call my pdoc. Well I'm heading into the bathtub to take a cool Aveeno oatmeal bath. I'll keep everyone updated.
Posted by jodie on January 19, 2003, at 19:57:46
In reply to Re: can this thread be attached » Jim Boardman, posted by Dr. Bob on January 19, 2003, at 18:53:57
I have a post above about my allergic reaction. Thought I would let everyone know in case they don't see it way up there.
Posted by BekkaH on January 19, 2003, at 20:20:02
In reply to Re: Strattera Allergic Reaction, posted by jodie on January 19, 2003, at 19:51:40
Hi Jodie,
Oh! What a nuisance! Your rash started just when things seemed to be improving. I wonder whether it might have been the Lexapro? The other day you said you were going to resume the Lexapro. And if it wasn't that, perhaps it was some interaction between Strattera and Lexapro. Some doctors like to have a patient on one drug at a time, at least for a while, so they can see what's doing what. Introducing too many new variables just complicates matters. I hope your rash goes away soon. Maybe you can resume Strattera at a later date and proceed more slowly. When the rash appeared, were you on any medicines others than Strattera and Lexapro?
Posted by tia on January 19, 2003, at 20:21:16
In reply to Re: Straterra -Second Day, posted by tia on January 18, 2003, at 17:09:31
Well today was different then the first two. I didnt have a lot of energy. I didnt have anxiety attacks either. My bladder is still acting up. I have interstitial cystitis and i am thinking that the straterra is not helping. I am still taking 40mg until tuesday then i move up to 60mg.I have another question: I was on zoloft years ago and did great on it. The only thing was i had to go off of it because of financial reasons. I tried it again about a year ago but had a serious problem with yawning. Has anyone experienced this before?
Tia
Posted by zenclear on January 19, 2003, at 20:44:08
In reply to Re: Strattera Allergic Reaction, posted by jodie on January 19, 2003, at 19:51:40
> Well I've been on Strattera for several days now. Yesterday I started breaking out with little red itchy bumps on my legs. It spread to my arms, back, belly, chest, and neck. Today the rash started getting worse. It was burning and itching so bad, I was going insane. I finally went to the ER, they believe it was a delayed allergic reaction to the Strattera. They gave me shots of benadryl, epinepherine, and a steroid. My face is also getting a little puffy. They released me with a prescription of Medrol Pak ( a steroid), and told me to take benadryl on a regular basis. I haven't taken any other meds that could have caused it. I took the sample bottle of strattera with the paper insert to the ER with me. The Dr. looked it over. They do believe the Strattera caused this. I still have a horrible rash. I itch, but the meds have helped a little. They told me to stop taking my strattera, and call my pdoc. Well I'm heading into the bathtub to take a cool Aveeno oatmeal bath. I'll keep everyone updated.
Geeez, I am glad you got some medical attention on this! This happens to me a lot, and with me, more often than not, it's not an allelrgic reaction but more of a chemical sensitivity. There's a technical difference, but the effects have the same implications: the med is not an option, etc.
With this one, the overall drying effects manifest in me across several domains, from skin rashes to dermatitis etc. In fact, it made my scalp bleed, due to sore-like eruptions. I did not notice this until a day or so after I stopped.
Take care, and do the right thing for yourself! Listen to your own instincts.
Posted by jodie on January 19, 2003, at 22:19:57
In reply to Re: Strattera Allergic Reaction- jodie, posted by BekkaH on January 19, 2003, at 20:20:02
> Hi Jodie,
> Oh! What a nuisance! Your rash started just when things seemed to be improving. I wonder whether it might have been the Lexapro? The other day you said you were going to resume the Lexapro. And if it wasn't that, perhaps it was some interaction between Strattera and Lexapro. Some doctors like to have a patient on one drug at a time, at least for a while, so they can see what's doing what. Introducing too many new variables just complicates matters. I hope your rash goes away soon. Maybe you can resume Strattera at a later date and proceed more slowly. When the rash appeared, were you on any medicines others than Strattera and Lexapro?They told me to resume lexapro. They didn't think the two should interact in a bad way. It's hard telling though. I had to educate the ER staff about Strattera. They hadn't heard of it, thats why I took the bottle & the paper insert. Every once in a while I take Klonopin for anxiety, and in the past for seizures. I've been taking that off and on for a couple of years. But thats it, no pain meds or anything else. When I left the ER, I went to CVS Pharmacy to get my prescription & Benadryl. I spoke with the pharmacist about my rash & being on the Strattera. I explained to him that I started it over a week ago, and the rash started yesterday. He said a delayed allergic reaction to drugs related to Strattera are not uncommon. He said they received a fax from Lilly about Strattera, it stated side effects including possible allergic reactions. The pharmacist didn't see a problem for me to resume my lexapro. Like I said, I'm going to call my pdoc and see what she thinks. I had this same problem back when I was in high school (the severe rash), they thought it was an allergic reaction to codimal I was taking (the codeine). I took a Tylenol w/ codeine several years later, and I had no reaction from it. So I'm not so sure it was the codeine then. I look so funny. It reminds me of when I had measles as a child. Red dots everywhere!!! Thank you for your concern!!!!
Posted by jodie on January 19, 2003, at 22:26:43
In reply to Re: Strattera Allergic Reaction » jodie, posted by zenclear on January 19, 2003, at 20:44:08
Thank you for the cocern & support Zenclear!!!! I really think it is the Strattera since any other meds I've taken like lexapro & klonopin, I never had a problem like this. My pharmacist said a delayed allergic reaction may be expected w/ Strattera. Thanks again!
Posted by BekkaH on January 19, 2003, at 23:50:23
In reply to Re: Strattera Allergic Reaction, posted by jodie on January 19, 2003, at 22:26:43
Jodie,
Did you or do you have a fever?
Posted by BekkaH on January 20, 2003, at 0:10:23
In reply to Re: Strattera Allergic Reaction - Jodie, posted by BekkaH on January 19, 2003, at 23:50:23
Jodie,
Are you familiar with the medicine, Lamictal? Lamictal is an anticonvulsant that has been used very successfully in many depressed patients, primarily for antidepressant augmentation. It is also used successfully for treating bipolar depression. The reason I'm bringing it up here is that a rare but dangerous rash has been associated with Lamictal, and apparently the likelihood of the rash occurring is greatly reduced if Lamictal is started at a very low dose and increased very, very slowly over many weeks. The rash is also less likely if Lamictal is NOT combined with other anticonvulsants. Lamictal is also associated with many other, benign rashes. We know so little about Strattera, but I'm wondering whether rashes will prove to be less likely if the dose is started very low and increased very slowly, and if the medicine isn't combined with too many other meds. Perhaps the comparison is not a valid one since the two medications have such different mechanisms of action. I'm just thinking "out loud."
Posted by jodie on January 20, 2003, at 0:45:14
In reply to Re: Strattera Allergic Reaction - Jodie, posted by BekkaH on January 20, 2003, at 0:10:23
> Jodie,
> Are you familiar with the medicine, Lamictal? Lamictal is an anticonvulsant that has been used very successfully in many depressed patients, primarily for antidepressant augmentation. It is also used successfully for treating bipolar depression. The reason I'm bringing it up here is that a rare but dangerous rash has been associated with Lamictal, and apparently the likelihood of the rash occurring is greatly reduced if Lamictal is started at a very low dose and increased very, very slowly over many weeks. The rash is also less likely if Lamictal is NOT combined with other anticonvulsants. Lamictal is also associated with many other, benign rashes. We know so little about Strattera, but I'm wondering whether rashes will prove to be less likely if the dose is started very low and increased very slowly, and if the medicine isn't combined with too many other meds. Perhaps the comparison is not a valid one since the two medications have such different mechanisms of action. I'm just thinking "out loud."BekkaH-
No I didn't have a fever at the ER. I have a digital ear thermometer. I took my temp. a couple of hours b4 I went, it was 100.5.
Yes I am familiar with Lamictal. I hadn't heard about the rash. It is very possible that it could be the strattera causing the rash, especially since I started at a high dose, after only 3 days my pdoc had me on 80 mg's. I'm 120 lbs, 5'5", so maybe it was just too much. I would seriously consider trying a lower dose and gradually increasing, but I know I could not tolerate a rash like this again. I'm scared of the medication now. Thank you for your "thinking out loud" because I have the same thoughts. I just wish I knew for a fact what caused this horrible rash.
Posted by jodie on January 20, 2003, at 0:57:58
In reply to Re: Strattera Allergic Reaction - Jodie, posted by jodie on January 20, 2003, at 0:45:14
Another thought of mine is maybe its not even medication related. I don't recall eating anything unusual. I have no food allergies that I'm aware of. I always freak myself out over these kinds of things. I have been on the internet all night looking for possible diagnosis. You wouldn't believe some of the diseases I've been reading about that a rash can be a symptom. I decided to quit looking at diseases and symptoms for the night, I'll end up giving myself a panic attack. I did that once. I was having chest pains, so I got on the internet and convinced myself I was having a heart attack. I started gasping for air, and almost passed out. We had to go to the ER. It turned out to be acid reflux, and a panic attack!!! Well I'm off to bed, after I cover my body with benadryl gel :-)
Posted by BekkaH on January 20, 2003, at 1:02:29
In reply to Re: Strattera Allergic Reaction - Jodie, posted by jodie on January 20, 2003, at 0:45:14
I think that Lilly, the company that makes Strattera should know about this rash. I wonder whether your pdoc and/or the ER you went to should report it. I wonder whether this has happened to many others.
Do you feel sick in any way, other than the rash? Is your temperature normal now?
Posted by jodie on January 20, 2003, at 11:38:18
In reply to Re: Strattera Allergic Reaction - Jodie, posted by BekkaH on January 20, 2003, at 1:02:29
> I think that Lilly, the company that makes Strattera should know about this rash. I wonder whether your pdoc and/or the ER you went to should report it. I wonder whether this has happened to many others.
>
> Do you feel sick in any way, other than the rash? Is your temperature normal now?I thought about that. I'm going to mention it to my pdoc about reporting the rash. I don't feel sick, just tired. Benadryl really knocks me out! I don't have a temperature now.
Posted by jodie on January 20, 2003, at 15:46:26
In reply to Re: Strattera Allergic Reaction - Jodie, posted by jodie on January 20, 2003, at 11:38:18
> > I think that Lilly, the company that makes Strattera should know about this rash. I wonder whether your pdoc and/or the ER you went to should report it. I wonder whether this has happened to many others.
> >
> > Do you feel sick in any way, other than the rash? Is your temperature normal now?
>
>
>
> I thought about that. I'm going to mention it to my pdoc about reporting the rash. I don't feel sick, just tired. Benadryl really knocks me out! I don't have a temperature now.
Well, I just spoke with my pdoc, she said her Lilly Rep. will be in tomorrow, and she is going to let her know. She said she agrees that I should stay off the Strattera. I have an appointment coming up soon, she said we would discuss other options, like stimulants. She said she has had great success with her patients and Adderall. She told me to continue with the Lexapro for now. She said Strattera is just so new right now, and I'm not the first complaint of allergic reactions on Strattera at their office. She thinks it would just be risky for me to even wait for a while and start at a lower dose. I had mentioned that possibility to her. So I guess it will be stimulants for me.
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