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Dr. Bob is Robert Hsiung, MD,
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Posted by katz on October 2, 2002, at 15:57:06
I have just finished a five day trial of Sam-e, 400mg. I have taken it with a B-100 complex but have not used the sublingual B-12. The results of this trial have been discouraging. The SAM-e has cuased so much sedation that I am acutally sleeping around the clock! I feel like I have O.D'd on melatonin! Does anyone have any insight on what could be causing this sedation? I would appreicte any insight that anyone has to offer. Thanks,
Posted by Bill L on October 3, 2002, at 16:04:24
In reply to SAM-e making me sleepy! Please advise!!!, posted by katz on October 2, 2002, at 15:57:06
SAM-e generally causes people to feel jittery. I don't think sleepiness is too common of a side effect. But can cause insomnia. Do you think that it's causing you to not sleep very well and that's why you are tired?
Why are you taking SAM-e. For depression? Are you taking other drugs as well?
Posted by katz on October 3, 2002, at 18:04:23
In reply to Re: SAM-e making me sleepy! Please advise!!!, posted by Bill L on October 3, 2002, at 16:04:24
Hi Bill! I understand that my reaction to SAM-e is atypical and that is why I was wondering if anyone had any insight as to what could be causing this problem. Perhaps I am not metabolizing the SAM-e normally. I am sleeping solidly! If I slept any more soundly I would be in a coma or dead! Most SSRI's causue the same problem with sleepiness. I suffer from dysthymia, anhedonia and social phobia. I was taking the SAM-e both for depression and to boost energy. I recently ended a retrial of Prozac because it too was causing fatigue and apathy. Stimulants (ritalin, reboxetine, wellbutrin) are of little use. Despite high dosages, they are not very stimulating. I just can't seem to find the energy or motivation to get out of bed! I've tried just about everything there is to try. I was wondering if my reaction to SAM-e could be a hint to an as yet undiscovered biochemical problem. Thus far, I have found yohimbe and estrogen mildly helpful but nothing close to a solution. All thoughts and suggestions will be greatly appreciated. Also, I would like to know if anyone else has had a similar reaction to Sam-e. I don't know whether to discontinue it altogether, lower the dose, raise the dose or to try to take it at bedtime. I'm confused and need some advice. Thanks!
This is the end of the thread.
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