Psycho-Babble Medication Thread 112280

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

On questions. YMMV. Truth is not absolute.

Posted by Shawn. T. on July 14, 2002, at 3:24:06

I will respond to all of the questions that I haven't given responses to. Anything more than that I can't guarantee anything. I apologize to the bipolars or anyone else I may have left out, but I feel others have picked up where I have left off. Such good people!

As an endnote, I will post a complete description of about 75% of what I know. I sent the description to the doctors that I feel can help me the most with this problem. I'll go ahead and publish the names; I think that they deserve the appreciation of the nation. I can't be held responsible for any treatment decisions made without first seeking a doctor's help. Most of the drugs that I speak of are usually obtained at the advice of a doctor. I strongly suggest that no one take illegal drugs. MDMA is bad period. I'll eventually try to explain why they're bad for you. I especially dislike alcohol, tobacco, and caffeine. I will not be held responsible for any of this, but I'd like to think it's information that could save lives. I have edited my letter just a tiny bit. I apologize for my poor editing on everything. There are not enough hours in a day, and I didn't even read some of my posts twice. I just was receiving so very little criticism. I thank those who criticised me both positively and negatively. I'd like to thank cybercafe yet again.


Dear Dr. Lieberman,

I read the abstract on your idea about Antiglucocorticoid treatments in psychiatry. These treatments are not only important in psychiatry, as I am sure you already know. I put the following together. I know more, but I just included the most interesting information. I chose to share all of this with you because of your degree in chemistry and extensive knowledge of psychotherapy and group theory by the way. I think that our knowledge could fit together nicely. Please feel free to correct any errors I may have made.

Possible model for mental health disorders:

Anxiety Disorders: High cortisol, DHEA

Depression: High cortisol and Low DHEA-S

Chronic Fatigue: Low cortisol, DHEA, DHEA-S

Depression: High cortisol and Low DHEA and/or DHEA-S

Fibromyalgia: High cortisol and Low DHEA-S (and/or
DHEA?), androgens

A note on this: perhaps some chronically obese
patients are unable to properly breakdown cholesterol? Perhaps anorexics break it down too easily? See the following. I would guess that patients with bulimia have lower levels of 17beta-estradiol than those with anorexia as well.

Anorexia: High 3alpha, 5alpha-THP, DHEA, DHEA-S,
cortisol and Low 17beta-estradiol, testosterone

Bulimia: High 3alpha, 5alpha-THP, DHEA,
DHEA-S,cortisol and Low 17beta-estradiol.

AIDS w/ symptoms: HIV+ and High cortisol, testosterone, estrone and Low DHEA, DHEA-S, androgens (Advanced AIDS sees increased levels of estradiol)

AIDS w/o symptoms: HIV+ and High cortisol, estrone,
androgens and Low DHEA, DHEA-S (I believe these patients should exhibit low testosterone as well)

Furthermore, individuals with low levels of DHEA and high levels of testosterone (DHEA is a precursor to testosterone and androgens) are at a higher risk to contract HIV.

"Initiating protease inhibitor combination therapy was
associated with an increase in DHEAS over 6 months."

On anxiety disorders:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=9223436

On chronic fatigue:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=9899382
and
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29938079

On depression:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=10889076

On Fibromyalgia:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=4982488

On Anorexia & Bulimia:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=16264486

On AIDS:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29503255
and
http://www.naples.net/~nfn03605/dheaaids.htm

See
http://www.psychosomaticmedicine.org/content/vol61/issue5/images/large/G0465F1.jpeg
For the link between cholesterol and DHEA.

And finally DHEA-S levels linked to cardiovascular
disease. This also helps to explain increased rates of
major depressive episodes in the elderly.
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=19458812

I believe that schizophrenia may not involve glucocorticoids. I'm basing this on the inconclusiveness on the only study involving the two. I put the following together to help explain schizophrenia.

M,100,907 is a potent 5-HT2 antagonist. It has the same, perhaps even better, effects as current drugs available schizophrenia treatment, only without the extrapyramidal side effects. Take for example Zyprexa (Olanzapine). Zyprexa exerts its effects on a very wide range of receptors. See http://www.gpcr.org/7tm/ligand/Organon/Tablig/LIG_C132539061.html

5-HT1a effects are within the range of weakly active, so that rules out 5-HT with regards to possible explanation of Zyprexa's efficacy. With regards to the dopamine receptors, the evidence seems to show that their activation is not necessary for the treatment of schizophrenia and leads to increased extrapyramidal side effects. See
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=1986311

With regards to NAa1, I am unaware of any reasoning that would support a role for it in schizophrenia. The effects on acetylcholine are unnecessary and produce side effects. Effects on histamine receptors, however,are transient and should disappear after a few weeks. This would imply 5-HT2 antagonism as the mechanism of schizophrenia efficacy in Zyprexa. As mentioned in the study provided above, 5-HT2
antagonism is the key to treating schizophrenia. The extra effects on receptors unrelated to schizophrenia seen in current treatments are providing both the positive and negative effects of these drugs.

M,100,907 would provide all of the positive effects of 5-HT2 antagonism and none of the negative effects caused by anticholinergic, antihistamine, and dopaminergic actions. I suggest that M,100,907, among other positive actions, helps to modulate dopamine release. It would prevent spikes in dopamine release in response to stressors or the introduction of drugs such as amphetamines. See http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=24612534

With regards to the negative and positive effects of schizophrenia and how M,100,907 affects these, see
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=7411933
and
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=11283291

Also examine the following study for an explanation of
hallucinations in schizophrenic patients:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=24922782

Moreover, a 5-HT2 antagonist, Mirtazapine, has been given regulatory approval in the United States. For this reason, I would suggest that a 5-HT2 antagonist would be a very tolerable agent to cure schizophrenia. M,100,907 has been shown to be more effective than both clozapine and haloperidol. Until M,100,907 is released, I would suggest that Remeron is currently the drug with the fewest side effects for schizophrenia treatment. Note that Aventis owns the rights to M,100,907 and is currently conducting clinical trials.

I am also interested in utilizing M,100,907 as an antidepressant agent. In combination with a drug like gepirone (Organon owns this one), a potent antidepressant agent could be created. Gepirone is highly selective for the 5-HT1a receptor, but would be ineffective if used alone. This is because increased 5-HT1a receptor activation in combination with 5-HT2 activation would result in increased levels of cortisol and prolactin. (I believe that Wellbutrin's positive effects on SSRI therapy may be due to dopamine's inhibitory actions on prolactin by the way. Hyperprolactinemia could be nicely treated by Wellbutrin + Remeron in my opinion.) Pindolol could be added during initial treatment to remove the delay in onset.

I'm a big fan of Remeron as far as currently approved drug treatment for depression goes.
See
http://www.thieme.de/abstracts/pharmaco/abstracts2001/daten/187.html
and
http://www.thieme.de/abstracts/pharmaco/abstracts2001/daten/default_inhalt.html
and
http://www.biopsychiatry.com/corticosteroid.htm

I find this interesting:
http://www.biopsychiatry.com/gluconew.htm
Also this news on lithium:
http://www.thieme.de/abstracts/pharmaco/abstracts2001/daten/default_inhalt.html

I am no big fan of SSRI's unless mixed with a 5-HT2a and 5-HT2c antagonist (I'm not well read on 5-HT2b). I especially don't like Paroxetine. See
http://www.thieme.de/abstracts/pharmaco/abstracts2001/daten/default_inhalt.html


Also, since 5-HT5 is negatively coupled to adenylyl cyclase, wouldn't have effects on cortisol excretion? My understanding is that adenylyl cyclase affects cAMP which affects cortisol excretion. I've got some good ideas on why caffeine leads to weight loss and acne too based on adenylyl cyclase.

5-HT6 seems interesting because it's related to glutamate levels. See
http://nootropics.com/sb-271046/memory.html
Just think what this knowledge could do for Alzheimer's Disease!
See
http://www.cortexpharm.com/html/research/glutschiz.html

On a related note, see
http://www.cortexpharm.com/html/research/ampschiz.html
and
http://www.twst.com/templates/roth/ppt/cor/profile.pdf

Consider the possibilities of combining this drug with a 5-HT2a and 5-HT2c antagonist! Are you not filled with a heightened sense of optimism?


I've also got interests in 5-HT1f's impact on migraines because it has vascular related functions.

You might be interested in my theory of SSRI related male sexual dysfunction. 5-HT1a activation in combination with 5-HT2a and 5-HT2c leads to increased prolactin excretion. Increased levels of prolactin lead to hypogonadism, with decreased sex drive, decreased sperm production and possible impotence. It also makes your breasts larger. I can't wait for M,100,907 (the 5-HT2 selective antagonist) to be released.

Also 5-HT1a agonists seem to cause up-regulation by the way. This makes me think that taking an SSRI after consuming MDMA really is a good idea.
The increase in serotonin caused by an SSRI would prevent serotonin receptor up regulation in response to a massive serotonin decrease after taking MDMA.
http://mdma.net/mdmaeff.htm

I believe asthma may be serotonin related. See
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=25950478

I am disgusted with SSRI monotherapy in our postmodern world. See
http://www.socialaudit.org.uk/210proza.htm#2.10 Prozac

Don't you think that what I've said about 5-HT2 antagonism plays into this? Also I really don't like benzodiazapines; I got put on Ativan due to a bad combination of drugs (I explain this later) and somehow managed to OD. The police brought me home, and my parents were not very happy. I also cut a huge gash into my arm while on benzo's.

I also have a good theory for natural selection based on HPA axis disregulation. I believe that we should start calling it the LHPA axis by the way (L is for limbic). I can tie rank theory into this. With your help, I could advance my theory a great deal I perceive.

Oh yeah, do you know anything about pituitary adenylate cyclase-activating peptide (PACAP) or peptide histidine methionine (PHM)'s relation to depression? How about autism? Could you explain the relation between PHM and VIP?http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=30323743

Could you tell me if taking calcium supplements improves short term memory? Is the normal supply in your body enough to support sensitisation? Is it a good idea to take say three times the daily reccommended amount?

Know anything about stress and infertility?
http://members.aol.com/jefferiesw/articles/1994.html

Check out
http://www.biopsychiatry.com/cckanx.html

What do you know about drugs that can block enzymes? Specifically, 17,20 lyase and 17, 20 lyase SST and 17-OH and 21-OH and 11-OH and 18-OH and 18-OH-D and 3-beta-HSD and 17-beta-HSD and aromatase and cholesterol scc (I don't know if those last two are considered enzymes or not). Could aromatase levels help explain some differences between the sexes? What do you know about the protease inhibitors as antidepressants? Specifically, the anti-fungal one (I can't remember the name right now, starts with keta). Don't you think, based on the information I gave earlier, that very selective enzyme blockers could combine to help solve some mental health issues?


Might there be a link between this
http://opioids.com/naloxone/depcrf.html
and this (wow!)
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11931344&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+dopamine&count=12
and this (that is important to know)
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29125975

Want more? Think you could help me get a scholarship to study pharmacy? I received a 34/36 on the english subsection of the ACT and was salutatorian of my high school class (because of a b in the introduction to art class that I took my freshman year). I sadly dropped out of the University of Illinois at Chicago because of depression. I was so depressed that I didn't even bother to tell them and just stopped going to class. I was studying computer science. I'm now on Remeron and Wellbutrin and am amazed to find that I am more intelligent than ever before! All of these ideas were concocted when my Remeron really kicked in, and I'm only on 7.5mg/day. I started taking DHEA today. I'm all too eager to get my IQ retested (I know at last check it was from 135-140). I'm also really interested in g and the heritability of IQ. I think that I have, in Linda S. Gottfredson's words, tended to "seek out the life niches that are most congenial to [my] genetic proclivities."

I would be of great help to you or one of your colleagues as a research assistant in my opinion. California would be a much more ideal intellectual climate for me to be in. I haven't thrown all my knowledge at you, just some of the most interesting stuff. I would like you to get in contact with Herbert Meltzer at Vanderbilt University if you are interested in helping me with my work. He's been out of town the past couple days, and I haven't been able to contact him yet. He's done some nice work on 5-HT2 and it's link to glucocorticoids. See
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=7178095
and also this link which is based on his work. It details 5-HT1a's effects on cognitive processes nicely.
http://www-np.unimaas.nl/PsyPharm/postersBAP/posterwim.html

Time magazine may publish some of my writing in their magazine. I didn't give them anywhere near this much information, however. Just the bit on schizophrenia. I've been assured that I have the attention of all of their editors. I was upset by their article on Understanding Anxiety in the June 10 issue.

I've only been at antidepressant research for 19 days, before that I knew nothing about it. I have found almost all of this information in the past three days. I have had some sleepless nights (yes, I know it's bad for you). I would love to combine everything I know into a book or article; I know I could write something groundbreaking. I always thought that I had it in me to make a difference in the world. Perhaps with the help of yourself and Dr. Meltzer, I could really save some lives. I haven't even started very much research on dopamine, acetylcholine, and enzyme reducers.


An addendum (Mirtazapine related, more information about why I like it so much):

A well done study on effects of Remeron on alertness: http://www4.infotrieve.com/newmedline/detail.asp?NameID=11001237&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+efficacy&count=

Information on Remeron's effect upon dopamine in the brains of rats: http://www4.infotrieve.com/newmedline/detail.asp?NameID=10762339&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+dopamine&count=12

Abstract on using Remeron as an augmentor to other antidepressants: http://www4.infotrieve.com/newmedline/detail.asp?NameID=11822997&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+efficacy&count=86

On taking Remeron for Panic Disorder http://www4.infotrieve.com/newmedline/detail.asp?NameID=11712626&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+efficacy&count=86

Comparison of Remeron and an SSRI(prozac) for PD: http://www4.infotrieve.com/newmedline/detail.asp?NameID=11593305&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+efficacy&count=86

Information on anxiety relieving effects on rats: http://www4.infotrieve.com/newmedline/detail.asp?NameID=11489459&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+efficacy&count=86

Study comparing Remeron and fluoxetine for depression: http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=7308933


Could you believe that what led me into all of this was my avid interest in philosophy? I became acquainted with some different theories of consciousness (animal consciousness is something I am particularly interested in, especially with regards to primates). David Chalmer's description of the hard problem of consciousness got me started on quantum mechanics research. When I couldn't find the answers I was looking for there (I do not accept Roger Penrose's ideas), I switched my studies to neuropsychopharmacology. I'm much more satisfied with using the complexity of neurotransmission and neuromodulation to help solve the hard problem. The days of looking at the brain only in terms of macro functions are thankfully in the past. Is it not a mistake to believe that the inability of a species to speak is predictive of a lack of intelligence? Are their abilities to experience and connect concepts not something we can determine? Is it not true that science not pervaded with an ever increasing demand to use interdisciplinary approaches to unravel the mysteries of nature? Note that you don't have to answer these questions, they are rhetorical.

Go to http://www.u.arizona.edu/~chalmers/ if you don't know what the hard problem is.

Note that my switch to researching mental health issues was also due to my confusion over my extremely negative reaction to mixing Paxil and Wellbutrin. I was not in my right mind on these two drugs by any means. I eventually discovered that they were interacting via the 2D6 isoenzyme of the P450 hepatic system. I strongly believe that hydroxybupropion has gone very overlooked, and more research needs to be done on this metabolite of bupropion. See
http://www.dr-bob.org/tips/split/Bupropions-metabolism.html

Everyone should check out information on mixing opiates with Remeron. Luvox drug interactions need to take place. Drugs that affect enzymes negatively (on an individual basis) should be discouraged.

Sincerely,

Shawn M. Thomas

 

Re: On questions. YMMV. Truth is not absolute.

Posted by Shawn. T. on July 14, 2002, at 3:26:39

In reply to On questions. YMMV. Truth is not absolute., posted by Shawn. T. on July 14, 2002, at 3:24:06

Could someone please remove my reference to MDMA???

Shawn

 

Re: concerned

Posted by tabitha on July 14, 2002, at 3:34:57

In reply to Re: On questions. YMMV. Truth is not absolute., posted by Shawn. T. on July 14, 2002, at 3:26:39

Hi Shawn,

I don't know you, but just reading your last 3 posts, I had the thought you seem a little manic right now. Are you feeling OK?

Tabitha

 

Re: concerned

Posted by Shawn. T. on July 14, 2002, at 4:10:21

In reply to Re: concerned, posted by tabitha on July 14, 2002, at 3:34:57

Yes. I promise you that I will use my information to help myself improve further.
I have never received so much positive criticism at once in my life. I apologize if I got a bit carried away. I don't care about the money; don't worry about it guys. You've already paid me more than enough.

Shawn

 

to shawnt

Posted by katekite on July 14, 2002, at 12:40:27

In reply to Re: concerned, posted by Shawn. T. on July 14, 2002, at 4:10:21

Hi Shawn,

I'm concerned about you too. You do seem more hyper than usual. It seems out of character for you to talk about money, about San Francisco, and to give out your address... seems like a lot of plans. Obviously I don't know you too well so if this sounds totally ridiculous I apologize.

I'd definitely call your pdoc. If it's nothing then he or she will tell you that.

Take care and sleep if you can.

Kate.

 

Re: to shawnt

Posted by Shawn. T. on July 14, 2002, at 12:52:17

In reply to to shawnt, posted by katekite on July 14, 2002, at 12:40:27

I won't lie and say that I didn't drink a caffeinated beverage (50mg). Sort of like my form of champagne, doing something that I know is naughty. As expected, it has already given me acne. I don't know about going to San Fransisco. We'll see. I really wasn't putting so much thought into remaining anonymous. I had submitted some of this to Time after all. I finally gave in and took my Remeron, so I'll be sleeping tight in a bit. I'd like to argue that I'm sleeping better than a staggering percentage of Americans. Don't worry about me. Caffeine really isn't good for me.

Thanks for your concern,

Shawn

 

Re: On questions. YMMV. Truth is not absolute.

Posted by Shawn. T. on July 14, 2002, at 13:02:49

In reply to On questions. YMMV. Truth is not absolute., posted by Shawn. T. on July 14, 2002, at 3:24:06

Should have said that Luvox drug interaction investigations need to take place. I correct any errors I find it this. I have already found some grammar mistakes.

 

Feeling sleepy

Posted by Shawn. T. on July 14, 2002, at 13:08:39

In reply to On questions. YMMV. Truth is not absolute., posted by Shawn. T. on July 14, 2002, at 3:24:06

I think that I might be about ready to take a good eight hour nap.

Shawn

 

Re: to shawnt

Posted by katekite on July 14, 2002, at 13:16:28

In reply to Re: to shawnt, posted by Shawn. T. on July 14, 2002, at 12:52:17

Ok, I'll promise not to worry if you promise to call your pdoc IF taking the remeron doesn't put you to sleep the way it is supposed to. OK?

[Calling a pdoc is not the kiss of death... it's a preventative measure.]

So is that a deal?

Kate


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