Psycho-Babble Medication Thread 76755

Shown: posts 1 to 22 of 22. This is the beginning of the thread.

 

Edronax - anyone on it?

Posted by nutsy on August 28, 2001, at 19:07:01

Anyone use it and comment v. other older ads?

 

Re: Edronax - anyone on it? » nutsy

Posted by SalArmy4me on August 28, 2001, at 20:41:31

In reply to Edronax - anyone on it?, posted by nutsy on August 28, 2001, at 19:07:01

I used 12 mg for a week and stopped to go on moclobemide. But it was extremely tolerable.

Journal of Clinical Psychopharmacology
Volume 20(1) February 2000 pp 28-34
"Double-Blind, Placebo-Controlled Study With Reboxetine in Inpatients With Severe Major Depressive Disorder":

Efficacy
"The mean HAM-D total score at baseline was similarly high in the patients randomly assigned to receive reboxetine (35.7) and placebo (35.1), thus indicating that the majority of patients in both groups were severely ill. The mean total scores at last assessment were 12.6 for the reboxetine-treated group and 30.6 for the placebo-treated group. The absolute reduction in the mean HAM-D total score at the last assessment compared with that at baseline was significantly greater in the reboxetine group than in the placebo group (23.1 vs. 4.5; p < 0.001). Furthermore, the response rate (i.e., patients achieving a >=50% reduction in HAM-D total score) at the last assessment was 74% of patients in the reboxetine group compared with only 20% in the placebo group (p < 0.001).

Analysis of the change in mean HAM-D total scores over time (Fig. 1) showed that reboxetine was associated with a significantly greater response than was placebo from as early as day 10 of treatment (p = 0.006). Furthermore, the mean HAM-D score continued to improve throughout the study period for patients in the reboxetine group, but not for those in the placebo group (Fig. 1).

When the individual symptoms and symptom clusters on the HAM-D were assessed, significant differences in favor of reboxetine were observed in depressed mood (p = 0.044) by day 10; early/middle/late insomnia (p = 0.006) and work and activity/retardation (p = 0.003) by day 14; anxiety-psychic/hypochondriasis (p < 0.001), anxiety-somatic/somatic symptoms-gastrointestinal (p < 0.001), and general genital symptoms (p < 0.001) by day 21.

The superiority of reboxetine over placebo was confirmed by changes in the mean Zung total scores and the mean scores on the CGI Severity of Illness and Global Improvement subscales. The improvement in the mean Zung total scores from baseline to the last assessment was significantly greater in the reboxetine group (from 66.3 to 42.8) than in the placebo group (from 65.2 to 58.6) (p = 0.001). Significant differences between the two groups in terms of Zung total scores were first apparent at day 14 (54.7 vs. 60.8; p = 0.035), confirming the early onset of action demonstrated by the reduction in the mean HAM-D total scores. Improvements in mean CGI Severity of Illness and Global Improvement scores from baseline to last assessment were significantly greater in the reboxetine group than in the placebo group (p < 0.001). At the last assessment, 82% of patients receiving reboxetine compared with only 28% of those receiving placebo were judged "much improved" to "very much improved." Similarly, the mean CGI Severity of Illness score was only 2.07 in the reboxetine group compared with 4.24 in the placebo group at last assessment. Significant differences between the two groups in terms of mean CGI Severity of Illness and Global Improvement scores were first apparent at day 14 (p = 0.025 for CGI Severity of Illness and p < 0.001 for CGI Global Improvement), again confirming an early onset of action. None of the changes in the efficacy assessments showed age or gender effect.

Tolerability
The overall incidence of newly observed signs and symptoms was 86% (N = 24 of 28 patients) in the reboxetine group and 46% (N = 13 of 28) in the placebo group. The most frequently reported adverse events in the reboxetine group were dry mouth (57% of patients) and insomnia (25%). As shown in Table 2, other newly observed signs and symptoms reported in 10% or more of patients in the reboxetine group included blurred vision, sweating, constipation, vomiting, tremor, hypotension, decreased appetite, and sexual disturbance, whereas those occurring in the placebo group were dry mouth, headache, and tremor.

The majority of newly observed signs and symptoms began in the first 10 days of treatment, and the mean duration was 10.2 days in the reboxetine group and 2.7 days in the placebo group (p < 0.001). Most were mild to moderate in intensity (94% in the reboxetine group and 98% in the placebo group), and only a small proportion were considered to be severe (6% and 2%, respectively; p = 0.038). A total of 67% of the newly observed signs and symptoms were considered definitely related to treatment in the reboxetine group compared with 38% in the placebo group (p < 0.01). However, the incidence of discontinuations because of newly observed signs and symptoms was equally low in both groups (one patient per group).

The mean decrease in standing systolic blood pressure over the period of the trial was significantly greater in the reboxetine group than in the placebo group (-4.5 vs. -0.7 mmHg; p = 0.036). Hypotension was reported as an adverse event in three patients treated with reboxetine, of which one case was rated as "severe." There were no differences between the groups with respect to diastolic blood pressure, heart rate, or supine systolic blood pressure. Moreover, there were no clinically significant changes in laboratory or ECG parameters in either group.

Concomitant medication to treat insomnia, agitation, or headache was administered to 3 of the 32 patients completing the trial: chloral hydrate was administered to 2 patients and acetaminophen and diazepam were each administered to 1 patient. No withdrawal effects were observed on abrupt withdrawal of reboxetine.

 

Re: Edronax - had it !

Posted by dreamer on August 29, 2001, at 0:30:30

In reply to Edronax - anyone on it?, posted by nutsy on August 28, 2001, at 19:07:01

> Anyone use it and comment v. other older ads?

I'd stick to strong coffee. Just my xperience


dreamer-caffinated

 

Re: Edronax - had it !

Posted by SLS on August 29, 2001, at 8:20:24

In reply to Re: Edronax - had it !, posted by dreamer on August 29, 2001, at 0:30:30

> > Anyone use it and comment v. other older ads?
>
> I'd stick to strong coffee. Just my xperience
>
>
> dreamer-caffinated


Hi.

I would recommend trying desipramine or nortriptyline first, as like reboxetine, they potently inhibit the reuptake of NE. They also have an excellent track record spanning at least 30 years. I have not been impressed with what I have seen with reboxetine. I tried it. Real bad experience, but that's only me. I would not eliminate it from consideration, however. If you haven't investigated the tricyclics yet, I would recommend trying one of them first. I don't think there is any real advantage to reboxetine with respect to side effects.


- Scott

 

Re: Edronax - had it !

Posted by petter on August 29, 2001, at 13:09:32

In reply to Re: Edronax - had it !, posted by SLS on August 29, 2001, at 8:20:24

> > > Anyone use it and comment v. other older ads?
> >
> > I'd stick to strong coffee. Just my xperience
> >
> >
> > dreamer-caffinated
>
>
> Hi.

Hi...

I completely agree. We had Edronax very early here in Sweden. I have never seen or heard anything positive from it. Of course on can combo it with an SSRI. But Its easier and cheaper to take Venlaflaxine with the dual efect.

I hope you can stand with my sometimes terrible spelling...

Regards//Petter
>
> I would recommend trying desipramine or nortriptyline first, as like reboxetine, they potently inhibit the reuptake of NE. They also have an excellent track record spanning at least 30 years. I have not been impressed with what I have seen with reboxetine. I tried it. Real bad experience, but that's only me. I would not eliminate it from consideration, however. If you haven't investigated the tricyclics yet, I would recommend trying one of them first. I don't think there is any real advantage to reboxetine with respect to side effects.
>
>
> - Scott

 

Re: Edronax - had it !

Posted by JohnL on August 29, 2001, at 15:33:33

In reply to Re: Edronax - had it !, posted by dreamer on August 29, 2001, at 0:30:30

> > Anyone use it and comment v. other older ads?
>

I tried it and hated it. It made my depression worse, not better, and also made me totally impotent. Reboxetine, as well as Buspar, are two of the most worthless drugs anyone ever invented. I'm sure there are people who do well with them, but they are real hard to find. Haven't heard of anyone doing well longterm with either of those meds.

For someone interested in boosting norepinephrine chemistry, I think a better approach is Desipramine or Nortriptyline, or my favorite Adrafinil. Adrafinil has helped many people here, but one weird thing about it is that it seems to work best with another med like Prozac for example. By itself it can be helpful, but combined with something else it can be much better. I like the special synergy that seems to exist between Adrafinil and Prozac.

Reboxetine stinks, but that is just my opinion. Clinical trials look pretty impressive. Why it doesn't work so well in the real world is a mystery to me. Maybe someone fudged the results of those clinical trials or something. I don't know. All I do know for sure is that I, as well as a bunch of other people here, have tried it and not liked it, and I cannot recall a single person who stayed with it.
John

 

Re: Edronax - had it ! » JohnL

Posted by SalArmy4me on August 29, 2001, at 15:54:02

In reply to Re: Edronax - had it !, posted by JohnL on August 29, 2001, at 15:33:33

How can you prove that adrafinil works on norepinephrine?

 

Re: Edronax - had it ! Buspar amitryptiline comme

Posted by nutsy on August 29, 2001, at 18:49:44

In reply to Re: Edronax - had it !, posted by JohnL on August 29, 2001, at 15:33:33

I agree with you on the Buspar - was a wasted month.

My biggest fear is I tried very low dose amitryptiline (sp?) - 1/10th what ever the normal dose is - for insomnia. This dose caused me to experience severe weakness (like i have the flu) which is my normal complaint (weakness) at about 10x what i normally feel during a bad time! Anyone comment on that >?? > >?

> > > Anyone use it and comment v. other older ads?
> >
>
> I tried it and hated it. It made my depression worse, not better, and also made me totally impotent. Reboxetine, as well as Buspar, are two of the most worthless drugs anyone ever invented. I'm sure there are people who do well with them, but they are real hard to find. Haven't heard of anyone doing well longterm with either of those meds.
>
> For someone interested in boosting norepinephrine chemistry, I think a better approach is Desipramine or Nortriptyline, or my favorite Adrafinil. Adrafinil has helped many people here, but one weird thing about it is that it seems to work best with another med like Prozac for example. By itself it can be helpful, but combined with something else it can be much better. I like the special synergy that seems to exist between Adrafinil and Prozac.
>
> Reboxetine stinks, but that is just my opinion. Clinical trials look pretty impressive. Why it doesn't work so well in the real world is a mystery to me. Maybe someone fudged the results of those clinical trials or something. I don't know. All I do know for sure is that I, as well as a bunch of other people here, have tried it and not liked it, and I cannot recall a single person who stayed with it.
> John

 

Re: Edronax - had it !

Posted by SLS on August 29, 2001, at 19:30:42

In reply to Re: Edronax - had it ! » JohnL, posted by SalArmy4me on August 29, 2001, at 15:54:02

> How can you prove that adrafinil works on norepinephrine?


Hi Sal.

I have not found anything of substance to prove that adrafinil or modafinil have any effect on NE (norepinephrine) reuptake or that they act as ligands of any NE receptor. Just about everything ever written about these drugs refer to the earliest studies that concluded they were agonists at the NE alpha-1 receptor. I bet if you were to look at the bibliographies of all of the recently published studies, you would find them all referring to one or two papers.

A friend of mine is a rather bright biochemist who has frequented psychotropic oriented symposia for the last ten years or so. Two or three years ago, he had the opportunity to speak directly with a principal R&D man who claimed to have helped to develop adrafinil. The pharmacologist told him that the earliest work establishing adrafinil and modafinil as NE alpha-1 agonists was in his words a "red-herring". The studies were wrong.

Last year, while surveying the abstracts on Medline, I discovered that some of the geniuses who were responsible for perpetuating this misinformation made a glaring mistake of logic in drawing their conclusions. They were able to demonstrate that prazosin, a NE alpha-1 antagonist, was capable of preventing or reversing some of the activating effects of modafinil in the lab. Unfortunately, the only thing this observation really proved is that the effects being studied required that these NE neurons be intact. That's all. And I ain't no genius. For all they knew, the therapeutic effects of modafinil might have been produced by tickling the funny-bone of the left arm - as long as those neurons along the way functioned properly.

There must be a significant difference in the pharmacology of adrafinil and modafinil, even though the majority of adrafinil is quickly metabolized into modafinil in the body. John and others who have tried both have described unequivocal differences in the way these drugs effected them. Because there is a paucity of information about adrafinil to be found on Medline, I find it more difficult to rule-out the possibility that something else might be going on there. Both drugs rather potently increase the concentration of extracellular glutamate in various areas of the brain. I am guessing that it is the stimulation of hypothalamic glutamatergic pathways that is responsible for the promotion of wakefulness. The pro-motivational effects might be produced by increasing glutamatergic activity at sites in the thalamus and hippocampus (the land upon which a college for water-horses is established), probably via efferents (inhibition of GABAergic?) to dopaminergic neurons in the nucleus accumbens.

Give the scientists a few more days. Maybe they'll change their minds again. In the meantime, I would not develop any hypotheses that rely upon the supposition that adrafinil and modafinil are agonists of the NE alpha-1 receptor.

I don't know why the hell I wrote all of that. Nothing good on TV.


- Scott

 

Adrafanil JohnL

Posted by Jacob on August 31, 2001, at 0:06:06

In reply to Re: Edronax - had it ! » JohnL, posted by SalArmy4me on August 29, 2001, at 15:54:02

and where is the evidence that Adrafanil synergizes with Prozac, but not, say, Zoloft.

Would you suggest first switching from Z. to Prozac and then adding Adrafanil?

Thanks for your posts, even if repetitive! and which is the best source for Adrafanil?


> How can you prove that adrafinil works on norepinephrine?

 

Re: Edronax - had it !

Posted by JohnL on August 31, 2001, at 5:50:11

In reply to Re: Edronax - had it ! » JohnL, posted by SalArmy4me on August 29, 2001, at 15:54:02

> How can you prove that adrafinil works on norepinephrine?

Good question. Unfortunately I can't prove it. There is a terrible shortage of good information on Adrafinil in the world of literature. However, the literature that does exist states noradrenergic action. Since there is nothing else to go on, and no opposing viewpoints in literature, I have to take it at face value. Probably the strongest evidence would be the manufacturer's label, which says Adrafinil is an alpha-1 agonist, which is part of the noradrenergic chemistry. Adrafinil supposedly mimics norepinephrine, and binds directly to norepinephrine receptors. It gives the benefits of increased NE without the side effects of increased NE. But like I said, that is just a unanimous finding of the literature out there. SLS has indicated that Adrafinil is not an alpha-1 agonist, that it instead works on other chemistries. That may or may not be true. What he states is not found in any literature. Even with all the shortcomings, I have no choice except to go with existing literature. The most credible literature as I see it is the manufacturer's label.

Years ago it was considered fact that ulcers were caused by stress and improper diets. Then they discovered a bacteria was involved. So even when we in our grandious wisdom believe something to be true without question, it is not unusual to see it later called into question. This also applies to all drugs and just about any topic you can think of. The best we can do is go with current existing data until stronger proof comes along. At this time, all existing data suggests noradrenergic action for Adrafinil. It mimics norepinephrine.

Someone else asked about proof of synergy between Prozac and Adrafinil. There is no proof in literature. I am simply going on observations from this board. Several people have noticed the same synergy that I have with Prozac, but not with other SSRIs. Purely anecdotal, but purely promising as well. I do not believe they were flukes or mere coincidence. There is something to it.

But back to the original topic of this thread, I still think Reboxetine stinks. Just my opinion, again based on anecdotal evidence from this board.
John

 

Re: Edronax - had it ! » JohnL

Posted by SLS on August 31, 2001, at 7:04:00

In reply to Re: Edronax - had it !, posted by JohnL on August 31, 2001, at 5:50:11

Dear JohnL,

Regarding pharmacodynamics, I have found that even manufacturer's labels and package inserts can be wrong, especially early in a drug's life. Modafinil (Provigil), the immediate metabolite of adrafinil, is a good expample. After being marketed in the US for awhile, they updated their package label from claiming it was a NE alpha-1 agonist to stating that they didn't know what the hell the drug did. Of course, they used nicer words.

The following is an excerpt from a recent Cephalon package insert for Provigil (modafinil). The insert is copyrighted 1999. It details the reasons why it has been concluded that Provigil does NOT bind to and stimulate NE alpha-1 receptors.

"Modafinil does not appear to be a direct or indirect alpha-1 adrenergic agonist. Although modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic receptor antagonist, prazosin, in assay systems known to be responosive to alpha-adrenergic agonists, modafinil has no activity. Modafinil does not display sympathomimetic activity in the rat vas deferens preparations (agonist-stimulated or electrically stimulated) nor does it increase formation of the adrenergic-mediated second messenger phosphatidyl inositol in in vitro models. Unlike sympathomimetic agents, modafinil does not reduce cataplexy in narcoleptic canines and has minimal effects on cardiovascular and hemodynamic parameters."

You can compare this with:

http://www.smart-drugs.com/ias-Modafinil.htm

Then, you can look at this:

http://www.nevapress.com/cnsdr/full/5/3/193.pdf

"The literature on modafinil, the primary metabolite of adrafinil is much more ex- tensive. This work has largely focused on the potential application of modafinil in the treatment of sleep disorders, and modafinil has recently received regulatory approval for the treatment of narcolepsy in the United States. Since the types of clinical trials that have been conducted differ (vigilance enhancement for adrafinil vs. narcolepsy for modafinil), it is not clear whether modafinil effectively replaces adrafinil or whether the two com- pounds are uniquely valuable for different applications. Most investigators assume that adrafinil and modafinil both serve as 1-adrenergic­receptor agonists. The evidence in support of this hypothesis, however, is weak, and other mechanisms of action are probable. This review focuses primarily on adrafinil, but it also reviews studies on modafinil that help to clarify the underlying mechanisms of action of adrafinil. This review also considers potential novel applications of adrafinil in the treatment of disorders associated with dementia."

Please let me know if there is anything else I can help you with.


- Scott

 

Re: Edronax - anyone on it?

Posted by PaintItBlack on August 31, 2001, at 8:10:53

In reply to Edronax - anyone on it?, posted by nutsy on August 28, 2001, at 19:07:01

> Anyone use it and comment v. other older ads?

A few years ago, I ordered Reboxetine from a European pharmacy (with my pdoc's prescription -- I'm rather anal about stuff like that). I went up to the recommended 8 mg daily and stayed there about a month.

No benefits (which makes it no different than most of the older ADs I've tried).

Contrary to all the hype, the side effect profile was atrocious. Terrible insomnia. Major-league constipation, although I was so numb there that I hardly noticed it. Loss of libido is an understatement; my penis might have been on another planet given the lack of sensation. I had no idea when (or whether) I had to urinate.

Overall, two thumbs down. It might have some value for chemical warfare, but not as an AD.

Paint It Black

 

Adrafinil - technical and manufacturer information

Posted by SLS on August 31, 2001, at 11:52:24

In reply to Re: Edronax - had it ! » JohnL, posted by SLS on August 31, 2001, at 7:04:00

For anyone who doesn't have the Adobe Acrobat Reader to view the link I provided in my previous post, here is a text version:

http://home.att.net/~sl.schofield/medical/adrafinil_modafinil.htm


Here is some additional manufacturer information:

Adrafinil (Olmifon)

Laboratoire L. LAFON
Laboratoire Louis Lafon
Siège
19, avenue du Pr Cadiot
94701 MAISONS-ALFORT
Tél : 01.49.81.81.00
France country code: 33
www.lablafon.com


LAFON
Adresse : 20, rue Charles Martigny
BP22
94701 MAISONS ALFORT
Telephone : 01.49.81.81.00
Telecopie : 01.48.98.13.72
France country code: 33


The Adobe Acrobat Reader is a free program to be used to view files in Adobe PDF format. It functions as a stand-alone viewer and integrates with your browser to view files on-line. You can download a copy of the Acrobat Reader from this web page:

http://www.adobe.com/products/acrobat/readstep2.html

Or download directly by clicking on this link:

ftp://ftp.adobe.com/pub/adobe/acrobatreader/win/5.x/ar500enu.exe


>
> Dear JohnL,
>
> Regarding pharmacodynamics, I have found that even manufacturer's labels and package inserts can be wrong, especially early in a drug's life. Modafinil (Provigil), the immediate metabolite of adrafinil, is a good expample. After being marketed in the US for awhile, they updated their package label from claiming it was a NE alpha-1 agonist to stating that they didn't know what the hell the drug did. Of course, they used nicer words.
>
> The following is an excerpt from a recent Cephalon package insert for Provigil (modafinil). The insert is copyrighted 1999. It details the reasons why it has been concluded that Provigil does NOT bind to and stimulate NE alpha-1 receptors.
>
> "Modafinil does not appear to be a direct or indirect alpha-1 adrenergic agonist. Although modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic receptor antagonist, prazosin, in assay systems known to be responosive to alpha-adrenergic agonists, modafinil has no activity. Modafinil does not display sympathomimetic activity in the rat vas deferens preparations (agonist-stimulated or electrically stimulated) nor does it increase formation of the adrenergic-mediated second messenger phosphatidyl inositol in in vitro models. Unlike sympathomimetic agents, modafinil does not reduce cataplexy in narcoleptic canines and has minimal effects on cardiovascular and hemodynamic parameters."
>
> You can compare this with:
>
> http://www.smart-drugs.com/ias-Modafinil.htm
>
> Then, you can look at this:
>
> http://www.nevapress.com/cnsdr/full/5/3/193.pdf
>
> "The literature on modafinil, the primary metabolite of adrafinil is much more ex- tensive. This work has largely focused on the potential application of modafinil in the treatment of sleep disorders, and modafinil has recently received regulatory approval for the treatment of narcolepsy in the United States. Since the types of clinical trials that have been conducted differ (vigilance enhancement for adrafinil vs. narcolepsy for modafinil), it is not clear whether modafinil effectively replaces adrafinil or whether the two com- pounds are uniquely valuable for different applications. Most investigators assume that adrafinil and modafinil both serve as 1-adrenergic­receptor agonists. The evidence in support of this hypothesis, however, is weak, and other mechanisms of action are probable. This review focuses primarily on adrafinil, but it also reviews studies on modafinil that help to clarify the underlying mechanisms of action of adrafinil. This review also considers potential novel applications of adrafinil in the treatment of disorders associated with dementia."
>
> Please let me know if there is anything else I can help you with.
>
>
> - Scott

 

Re: Edronax - had it ! SLS

Posted by JohnL on August 31, 2001, at 17:12:42

In reply to Re: Edronax - had it ! » JohnL, posted by SLS on August 31, 2001, at 7:04:00

Hi Scott,
Yeah, I agree with you completely about manufacturers not knowing exactly what a drug does, or rewriting what they think it does later on. I guess maybe that's why I tend to go with 'intuition' or 'whatever works', instead of focusing too much on the scientific theory end of it. I mean, if the researchers and scientists can't get it right, geez!

As always, thank you for an informative point of view. I happen to agree with you completely.
John

 

Re: Edronax - anyone on it?

Posted by HenryO on September 3, 2001, at 4:31:52

In reply to Edronax - anyone on it?, posted by nutsy on August 28, 2001, at 19:07:01

I took it for two weeks. I left several posts about it. It was definately not for me.

 

Re: Edronax - had it !

Posted by per ekstrom on November 12, 2001, at 3:36:02

In reply to Re: Edronax - had it !, posted by petter on August 29, 2001, at 13:09:32

I gave it a try a year ago and I have never tried any psychiatric drugs with such quick and intense side-effects. As if I binged 10 liters of strong coffe in 10 minutes, it was horrible.

Tried to stick with it for 10-12 dauys to see if the effect reversed to the opposite, as may happen, and would be heaven...but I couldn't stand it.


ADHD inattentive type. Was on no other meds at the time.


Got to be very efficent for some people out here....but just be careful.

Per

> > > > Anyone use it and comment v. other older ads?
> > >
> > > I'd stick to strong coffee. Just my xperience
> > >
> > >
> > > dreamer-caffinated
> >
> >
> > Hi.
>
> Hi...
>
> I completely agree. We had Edronax very early here in Sweden. I have never seen or heard anything positive from it. Of course on can combo it with an SSRI. But Its easier and cheaper to take Venlaflaxine with the dual efect.
>
> I hope you can stand with my sometimes terrible spelling...
>
> Regards//Petter
> >
> > I would recommend trying desipramine or nortriptyline first, as like reboxetine, they potently inhibit the reuptake of NE. They also have an excellent track record spanning at least 30 years. I have not been impressed with what I have seen with reboxetine. I tried it. Real bad experience, but that's only me. I would not eliminate it from consideration, however. If you haven't investigated the tricyclics yet, I would recommend trying one of them first. I don't think there is any real advantage to reboxetine with respect to side effects.
> >
> >
> > - Scott

 

Re: per ekstrom-Same effect I had! ZOOM (nm)

Posted by Phil on November 12, 2001, at 6:45:17

In reply to Re: Edronax - had it !, posted by per ekstrom on November 12, 2001, at 3:36:02

 

Re: per ekstrom-Same effect I had! ZOOM » Phil

Posted by sadf_gunner on November 12, 2001, at 9:50:35

In reply to Re: per ekstrom-Same effect I had! ZOOM (nm), posted by Phil on November 12, 2001, at 6:45:17

Took reboxetine for a month, switching from dothiepin (tricyclic) in an attempt to increase drive and rescue my career. Many and massive side effects similar to those mentioned elsewhere in this thread - most notably total impotence and vividly disturbing nightmares plus tremor etc. Switched back to dothiepin. Now after another major depressive episode, not controllable by large doses of the tricyclic, on 600mg. carbamazepine (to stabilise mood & prevent hypomania) + 75 mg. venlafaxine + small dose (20 mg.) of citalopram feeing better than I have for years.

 

Re: per ekstrom-Same effect I had! ZOOM

Posted by per ekstrom on November 12, 2001, at 10:38:22

In reply to Re: per ekstrom-Same effect I had! ZOOM » Phil, posted by sadf_gunner on November 12, 2001, at 9:50:35

I am glad you found a good mix that makes THE difference for you !

I haven't heard of any success with reboxetine. It's been around for over 2 years here in Sweden already. Side-effects in clinical practise are totally different from those reported in clinical trials...

There are trial on a similar ? (NARI) called Tamoxetine for adhd, could be worth a try anyway cause whatever those noradrenergic reuptake inhibitors do, they do it STRONG...But personally I think we don't need SSRI or NARI, we need selective pre and postsynaptic agonist and antagonist for all catecholamines. It would be the only way to achieve optimal indivdual response.

I am also better than for a looooooong time on Prozac 30mg and 20 mg of Ritalin.....

Will try Modafinil as it get available here in a few weeks time. Tried it once before and its was helping me a lot, very expensive though...very interesting pharmacology...The French always had a somewhat different approach to psychopharmacology...

Take care ALL !

Per

> Took reboxetine for a month, switching from dothiepin (tricyclic) in an attempt to increase drive and rescue my career. Many and massive side effects similar to those mentioned elsewhere in this thread - most notably total impotence and vividly disturbing nightmares plus tremor etc. Switched back to dothiepin. Now after another major depressive episode, not controllable by large doses of the tricyclic, on 600mg. carbamazepine (to stabilise mood & prevent hypomania) + 75 mg. venlafaxine + small dose (20 mg.) of citalopram feeing better than I have for years.

 

Re: Edronax - had it !

Posted by Gino on December 28, 2001, at 13:23:33

In reply to Re: Edronax - had it !, posted by petter on August 29, 2001, at 13:09:32

I have been on Edronax for about 7 months and coming from a clinically depressed beginning have ended a year of theraphy and am considering getting off the pill. I read and read all the negative points people make regarding the medication where in my case it actually made a diference after trying so many other ssri's (even thought this one is a nsri).

Yes i'm constipated. Yes i have no sex drive (well kinda - has been worse :-) one just has to put up with it and eventually it does turn round for the good.

Good luck to you all!

 

Am on it, still.

Posted by jeole on December 9, 2003, at 23:33:57

In reply to Edronax - anyone on it?, posted by nutsy on August 28, 2001, at 19:07:01

I have been on Edronax now for about two months and it has worked extremely well for me. I guess everybody is different. It helps me find the energy I need to survive each day, and it has balanced out some extreme mood swings and perhaps what you could call bipolar disorder. My moods are less extreme and wacky these days, and I feel more normal, though I do seem to have more anger than depression.


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