Psycho-Babble Medication Thread 64568

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Switching from an SSRI to an SNRI.

Posted by Xavi on May 29, 2001, at 5:54:53

After almost seven years on various SSRIs (but mostly Prozac) I discovered the existence of SNRIs and wondered if their side effects might be easier to tolerate (SSRIs have caused me to suffer unprecedented weight gain, daytime sleepiness, apathy, low libido etc). My doctor agreed to my switching over and so far, having been on Reboxetine for 10 weeks, I do feel more alert and my libido has improved somewhat. However, in making the switch I did experience what I imagine were withdrawal symptoms from the sertraline I had been taking - which I'm mentioning because I think the medical profession underestimates the severity of withdrawal from SSRIs. Obviuosly changing from an SSRI to an SNRI is not as trouble-free as changing from one SSRI to another. I was wondering if anyone else had been through a similar experience and if they had any comments to make on the effectiveness of the two types of AD. Also, has anyone managed to shift the weight they gained on SSRIs after making the change?

 

Re: Switching from an SSRI to an SNRI.

Posted by roo on May 29, 2001, at 9:19:41

In reply to Switching from an SSRI to an SNRI., posted by Xavi on May 29, 2001, at 5:54:53

What is an SNRI? Is Reboxetine a MAO inhibitor?
Can you get it in the US? I'm just curious b/c
I feel the same way you do about the SSRI's....

 

Re: Switching from an SSRI to an SNRI.

Posted by Xavi on May 29, 2001, at 9:54:23

In reply to Re: Switching from an SSRI to an SNRI., posted by roo on May 29, 2001, at 9:19:41

> What is an SNRI? Is Reboxetine a MAO inhibitor?
> Can you get it in the US? I'm just curious b/c
> I feel the same way you do about the SSRI's....

It's a noradrenaline reuptake inhibitor. Like seratonin, low levels of noradrenaline are thought to play a role in depression. There's a lot more to it than I'm qualified to explain, so it might be an idea to check out a website that can give you more information. Try the excellent Google search engine and key in the words Reboxetine. Basically, it's recommended for people whose mood may be improved by SSRIs but who are still left feeling apathetic, lethargic and anti-social.It's also used for the more severe cases of depression. As far as availability in the States is concerned, I'm not too sure. I live in the UK, where it's been available on prescription for a few years. I believe the manufacturers of Prozac have just brought out a combined SSRI and SNRI which I think is called Duoxetine and this should be available in the USA before it reaches the UK. Good luck!

 

Stupid question

Posted by lrc on May 29, 2001, at 17:48:45

In reply to Switching from an SSRI to an SNRI., posted by Xavi on May 29, 2001, at 5:54:53

> After almost seven years on various SSRIs (but mostly Prozac) I discovered the existence of SNRIs and wondered if their side effects might be easier to tolerate (SSRIs have caused me to suffer unprecedented weight gain, daytime sleepiness, apathy, low libido etc). My doctor agreed to my switching over and so far, having been on Reboxetine for 10 weeks, I do feel more alert and my libido has improved somewhat. However, in making the switch I did experience what I imagine were withdrawal symptoms from the sertraline I had been taking - which I'm mentioning because I think the medical profession underestimates the severity of withdrawal from SSRIs. Obviuosly changing from an SSRI to an SNRI is not as trouble-free as changing from one SSRI to another. I was wondering if anyone else had been through a similar experience and if they had any comments to make on the effectiveness of the two types of AD. Also, has anyone managed to shift the weight they gained on SSRIs after making the change?

------
What does SSRI and SNRI stand for and what in the heck do they mean?

 

Re: Stupid question - not » lrc

Posted by Cam W. on May 29, 2001, at 17:58:59

In reply to Stupid question, posted by lrc on May 29, 2001, at 17:48:45

> What does SSRI and SNRI stand for and what in the heck do they mean?

SSRI = Selective Serotonin Reuptake Inhibitor
(Blocks reuptake of serotonin between nerve cells; in essence, prolonging the action of serotonin - like adding serotonin between nerve cells)

SNRI = Selective Norepinephrine Reuptake Inhibitor
(Same as above, just substitute norepinephrine for serotonin)

- Cam

 

Re: Stupid question - not

Posted by SLS on May 29, 2001, at 18:24:14

In reply to Re: Stupid question - not » lrc, posted by Cam W. on May 29, 2001, at 17:58:59

> > What does SSRI and SNRI stand for and what in the heck do they mean?
>
> SSRI = Selective Serotonin Reuptake Inhibitor
> (Blocks reuptake of serotonin between nerve cells; in essence, prolonging the action of serotonin - like adding serotonin between nerve cells)
>
> SNRI = Selective Norepinephrine Reuptake Inhibitor
> (Same as above, just substitute norepinephrine for serotonin)
>
> - Cam


Hi Cam.

I was under the impression that SNRI stood for Serotonin-Norepinephrine Reuptake Inhibitor i.e. venlafaxine (Effexor) and duloxetine.


- Scott

 

Re: Stupid question - not (Oops!)

Posted by Cam W. on May 29, 2001, at 18:31:43

In reply to Re: Stupid question - not, posted by SLS on May 29, 2001, at 18:24:14

Scott - Oops, you are correct with respect to the post. Sorry, I was thinking of Edronex™ (reboxetine) as an SNRI. Sorry lrc. - Cam
>
>
> Hi Cam.
>
> I was under the impression that SNRI stood for Serotonin-Norepinephrine Reuptake Inhibitor i.e. venlafaxine (Effexor) and duloxetine.
>
>
> - Scott

 

Re: Lost in the translation » Cam W.

Posted by kazoo on May 29, 2001, at 20:22:18

In reply to Re: Stupid question - not (Oops!), posted by Cam W. on May 29, 2001, at 18:31:43

> Scott - Oops, you are correct with respect to the post. Sorry, I was thinking of Edronex™ (reboxetine) as an SNRI. Sorry lrc. - Cam
> >
> >
> > Hi Cam.
> >
> > I was under the impression that SNRI stood for Serotonin-Norepinephrine Reuptake Inhibitor i.e. venlafaxine (Effexor) and duloxetine.
> >
> >
> > - Scott

^^^^^^^^^
Wait a minute!

SNRI *does* mean Selective Norepinephrine Reuptake Inhibitor, and reboxetine *is* an SNRI, at least that's how I was made to understand it.

Don't tell me Eli Lilly had the gonads to change this just because they decided to combine the two! I'm surprised they didn't patent the word "selective."

This reminds me of when WINDOWS NT (WINNT) was first released and the neophytes thought it meant "Network Technology" when in reality it meant "New Technology."

Sheesh, what's in a name anyway?

And for all of you out there making gagillions of bucks via on-line stock trading, time to buy Lilly stock ... there's rumor of an Upjohn merger or buy-out.

kazoo

 

Re: Lost in the translation » kazoo

Posted by Cam W. on May 29, 2001, at 20:34:37

In reply to Re: Lost in the translation » Cam W., posted by kazoo on May 29, 2001, at 20:22:18

> > Scott - Oops, you are correct with respect to the post. Sorry, I was thinking of Edronex™ (reboxetine) as an SNRI. Sorry lrc. - Cam
> > >
> > >
> > > Hi Cam.
> > >
> > > I was under the impression that SNRI stood for Serotonin-Norepinephrine Reuptake Inhibitor i.e. venlafaxine (Effexor) and duloxetine.
> > >
> > >
> > > - Scott
>
> ^^^^^^^^^
> Wait a minute!
>
> SNRI *does* mean Selective Norepinephrine Reuptake Inhibitor, and reboxetine *is* an SNRI, at least that's how I was made to understand it.
>
> Don't tell me Eli Lilly had the gonads to change this just because they decided to combine the two! I'm surprised they didn't patent the word "selective."
>
> This reminds me of when WINDOWS NT (WINNT) was first released and the neophytes thought it meant "Network Technology" when in reality it meant "New Technology."
>
> Sheesh, what's in a name anyway?
>
> And for all of you out there making gagillions of bucks via on-line stock trading, time to buy Lilly stock ... there's rumor of an Upjohn merger or buy-out.
>
> kazoo
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
kazoo - I guess we will have to call Effexor an NSRI, then.

As for the merger, I thought that all the head honchos were on each others boards already and "merger" is a euphenism for phasing out jobs (ie. "down-sizing" so that board members can give each other bigger bonuses.

Hey, how do I get in on this?

The guy who took the wrong degree - Cam

 

Re: Lost in the translation » kazoo

Posted by SLS on May 30, 2001, at 8:16:17

In reply to Re: Lost in the translation » Cam W., posted by kazoo on May 29, 2001, at 20:22:18


> Wait a minute!
>
> SNRI *does* mean Selective Norepinephrine Reuptake Inhibitor, and reboxetine *is* an SNRI, at least that's how I was made to understand it.

No. The abbreviation SNRI is most often used to describe drugs that are reuptake inhibitors of both serotonin and norepinephrine. I think reboxetine is referred to as NRI.

BPD once stood for BiPolar Disorder. It is now used most often to mean Borderline Personality Disorder. (I really don't know why this term is used to describe the symptom cluster). Bipolar disorder has also sometimes been abbreviated as BAD - Bipolar Affective Disorder.


- Scott

 

Re: Lost in the translation » SLS

Posted by Sunnely on May 31, 2001, at 0:29:35

In reply to Re: Lost in the translation » kazoo, posted by SLS on May 30, 2001, at 8:16:17

Hi Scott,

If you base the antidepressant classification by the European's, reboxetine (Vestra, Edronax) will be classified as a NARI (Noradrenaline reuptake Inhibitor). Europeans prefer the term noradrenaline to norepinephrine.

Aside from the common antidepressant abbreviations such as SSRIs, SNRIs, TCAs, and MAOIs, the following also exist but not universally accepted:

SARI: Serotonin Antagonist Reuptake Inhibitor such as nefazodone (Serzone)

NDRI: Norepinephrine-Dopamine Reuptake Inhibitor such as bupropion (Wellbutrin)

NaSSA: Noradrenergic and Specific Serotonergic Antidepressant such as mirtazapine (Remeron)

RIMA: Reversible Inhibitor of Monoamine Oxidase A such as moclobemide (Manerix) and brofaromine.

************

>
> > Wait a minute!
> >
> > SNRI *does* mean Selective Norepinephrine Reuptake Inhibitor, and reboxetine *is* an SNRI, at least that's how I was made to understand it.
>
> No. The abbreviation SNRI is most often used to describe drugs that are reuptake inhibitors of both serotonin and norepinephrine. I think reboxetine is referred to as NRI.
>
> BPD once stood for BiPolar Disorder. It is now used most often to mean Borderline Personality Disorder. (I really don't know why this term is used to describe the symptom cluster). Bipolar disorder has also sometimes been abbreviated as BAD - Bipolar Affective Disorder.
>
>
> - Scott

 

Re: Lost in the translation

Posted by Helen36 on May 31, 2001, at 1:56:20

In reply to Re: Lost in the translation » kazoo, posted by SLS on May 30, 2001, at 8:16:17


> BPD once stood for BiPolar Disorder. It is now used most often to mean Borderline Personality Disorder. (I really don't know why this term is used to describe the symptom cluster). Bipolar disorder has also sometimes been abbreviated as BAD - Bipolar Affective Disorder.
>
>
> - Scott

The term Borderline came from the early days of psychoanalytic 'talk' therapy, when some patients appeared to get radically worse during treatment on the couch -- moving from functionally 'neurotic' to 'psychotic' in Freudian terms. This puzzled the Freudians no end, and they dubbed these patients 'borderline' psychotics.
Today the theory is that Clusteer II personality disorders involve an emotional lack of development, and when discussed incidents trigger past trauma, primitive coping mechanisms are displayed; thus the failure of traditional'talk' therapy and the Victorians' assessment of psychosis.

I like the modern proposals "emotional dysregulation disorder" or even "extended post-traumatic stress disorder" *much* better.

A long and totally unnecessary answer in this thread, but thought I'd jump right in! ;)

Helen

 

Re: Lost in the translation » Helen36

Posted by SLS on May 31, 2001, at 7:19:50

In reply to Re: Lost in the translation, posted by Helen36 on May 31, 2001, at 1:56:20

>
> > BPD once stood for BiPolar Disorder. It is now used most often to mean Borderline Personality Disorder. (I really don't know why this term is used to describe the symptom cluster). Bipolar disorder has also sometimes been abbreviated as BAD - Bipolar Affective Disorder.
> >
> >
> > - Scott
>
> The term Borderline came from the early days of psychoanalytic 'talk' therapy, when some patients appeared to get radically worse during treatment on the couch -- moving from functionally 'neurotic' to 'psychotic' in Freudian terms. This puzzled the Freudians no end, and they dubbed these patients 'borderline' psychotics.
> Today the theory is that Clusteer II personality disorders involve an emotional lack of development, and when discussed incidents trigger past trauma, primitive coping mechanisms are displayed; thus the failure of traditional'talk' therapy and the Victorians' assessment of psychosis.
>
> I like the modern proposals "emotional dysregulation disorder" or even "extended post-traumatic stress disorder" *much* better.
>
> A long and totally unnecessary answer in this thread, but thought I'd jump right in! ;)
>
> Helen


Dear Helen,

Thank you VERY much.


- Scott

 

Re: BPD » SLS

Posted by Helen36 on June 1, 2001, at 14:07:11

In reply to Re: Lost in the translation » Helen36, posted by SLS on May 31, 2001, at 7:19:50

> >
> >
> > The term Borderline came from the early days of psychoanalytic 'talk' therapy (...)

> > Helen
>
>
> Dear Helen,
>
> Thank you VERY much.
>
>
> - Scott


Scott,

But of course! ;) My ex-fiance was BPD and I have done immense amounts of research on the whole personality disorder spectrum of mental illness.

If you're REALLY interested in BPD (and brave!), check out my brand-new website chock-full of resources on BPD for those living with Borderlines in their lives:

http://home.hvc.rr.com/helenbpd


Helen


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