Psycho-Babble Medication Thread 64065

Shown: posts 1 to 15 of 15. This is the beginning of the thread.

 

Extreme edema, Effexor withdrawal or Wellbutrin?

Posted by mvaureen on May 23, 2001, at 23:58:19


I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

 

Re: Extreme edema: call pdoc asap » mvaureen

Posted by Sulpicia on May 24, 2001, at 0:54:34

In reply to Extreme edema, Effexor withdrawal or Wellbutrin?, posted by mvaureen on May 23, 2001, at 23:58:19

>
> I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

Hi--
I don't know if this link is going to work -- oh damn. It's late here..
The point here is that edema can be a sign of a allergic reaction to the wellbutrin, and a potentially serious one.
Can your pdoc or clinician and report it.
Now.
Feel better soon.
S.
Browse Alphabetically
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Bupropion HCl


(byoo-PRO-pee-ahn HIGH-droe-KLOR-ide)


Action
Indications
Contraindications
Route/Dosage
Interactions
Lab Test Interferences

Adverse Reactions
Precautions
Patient Care Considerations
Administration Storage
Assessment/Interventions
Patient/Family Education


Trade Name(s):

Wellbutrin

Tablets, 75 mg
Tablets, 100 mg

Wellbutrin SR

Tablets, sustained-release, 100 mg
Tablets, sustained-release, 150 mg

Zyban

Tablets, sustained-release, 150 mg

Indicates Canadian trade names.

Class: Antidepressant/Smoking deterrent

Action:

Exact mechanism of antidepressant activity or as a smoking deterrent
unknown; does not inhibit monoamine oxidase.

Indications:

Treatment of depression; aid to smoking cessation treatment.

Contraindications:

Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa;
concurrent treatment with or within 14 days of discontinuation of MAO
inhibitors; concurrent treatment with multiple bupropion products (eg,
coadministration of Zyban for smoking cessation and Wellbutrin for
depression).

Route/Dosage:

Antidepressant
Adults: PO 100 mg bid initially; may increase to 100 mg tid after 3 days.
Maximum daily dose 450 mg; maximum single dose 150 mg.
Sustained release: 150 mg daily initially; may increase to 150 mg bid.
Maximum daily dose 400 mg; maximum single dose 200 mg.

Smoking Deterrent
Adults: PO Initial dose: 150 mg for first 3 days increasing to 150 mg bid.
Do not give doses > 300 mg/day. Initiate treatment while patient is still
smoking. Patient should set target date to quit smoking within the first 2
weeks of treatment; continue treatment for 7 to 12 weeks. Maintenance:
Clinical data is not available regarding long-term treatment ( > 12 weeks)
for smoking cessation. Whether to continue treatment must be
determined for individual patients. Combination treatment: Combination
treatment with bupropion and nicotine transdermal system may be
prescribed for smoking cessation.

Interactions:

Carbamazepine: May decrease bupropion serum concentrations.

Ritonavir: May increase bupropion serum concentrations increasing risk of
toxicity.

MAO inhibitors, selegiline: May increase risk of acute bupropion toxicity.
Discontinue MAO inhibitors ≥ 14 days before starting bupropion.

TCAs: TCA plasma concentrations may be elevated.


Adverse Reactions:

CNS:
Abnormal thoughts; agitation; anxiety; depression; insomnia;
irritability; hallucinations; somnolence; suicidal ideation; seizures;
headache/migraine; tremor; nervousness; memory decreased;
paresthesia; CNS stimulation; increased libido.
CV:
Edema; chest pain; flushing; hypertension; hot flashes; stroke;
tachycardia; vasodilation; ECG abnormalities (eg, premature beats,
nonspecific ST-T segment changes); MI.

 

Re: Extreme edema: call pdoc asap - Ditto (np)

Posted by Cam W. on May 24, 2001, at 9:10:05

In reply to Re: Extreme edema: call pdoc asap » mvaureen, posted by Sulpicia on May 24, 2001, at 0:54:34

> >
> > I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?
>
> Hi--
> I don't know if this link is going to work -- oh damn. It's late here..
> The point here is that edema can be a sign of a allergic reaction to the wellbutrin, and a potentially serious one.
> Can your pdoc or clinician and report it.
> Now.
> Feel better soon.
> S.
> Browse Alphabetically
> A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
>
>
>
>
>
>
>
>
> Bupropion HCl
>
>
> (byoo-PRO-pee-ahn HIGH-droe-KLOR-ide)
>
>
> Action
> Indications
> Contraindications
> Route/Dosage
> Interactions
> Lab Test Interferences
>
> Adverse Reactions
> Precautions
> Patient Care Considerations
> Administration Storage
> Assessment/Interventions
> Patient/Family Education
>
>
> Trade Name(s):
>
> Wellbutrin
>
> Tablets, 75 mg
> Tablets, 100 mg
>
> Wellbutrin SR
>
> Tablets, sustained-release, 100 mg
> Tablets, sustained-release, 150 mg
>
> Zyban
>
> Tablets, sustained-release, 150 mg
>
> Indicates Canadian trade names.
>
> Class: Antidepressant/Smoking deterrent
>
>
>
> Action:
>
> Exact mechanism of antidepressant activity or as a smoking deterrent
> unknown; does not inhibit monoamine oxidase.
>
>
>
> Indications:
>
> Treatment of depression; aid to smoking cessation treatment.
>
>
>
> Contraindications:
>
> Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa;
> concurrent treatment with or within 14 days of discontinuation of MAO
> inhibitors; concurrent treatment with multiple bupropion products (eg,
> coadministration of Zyban for smoking cessation and Wellbutrin for
> depression).
>
>
>
> Route/Dosage:
>
> Antidepressant
> Adults: PO 100 mg bid initially; may increase to 100 mg tid after 3 days.
> Maximum daily dose 450 mg; maximum single dose 150 mg.
> Sustained release: 150 mg daily initially; may increase to 150 mg bid.
> Maximum daily dose 400 mg; maximum single dose 200 mg.
>
> Smoking Deterrent
> Adults: PO Initial dose: 150 mg for first 3 days increasing to 150 mg bid.
> Do not give doses > 300 mg/day. Initiate treatment while patient is still
> smoking. Patient should set target date to quit smoking within the first 2
> weeks of treatment; continue treatment for 7 to 12 weeks. Maintenance:
> Clinical data is not available regarding long-term treatment ( > 12 weeks)
> for smoking cessation. Whether to continue treatment must be
> determined for individual patients. Combination treatment: Combination
> treatment with bupropion and nicotine transdermal system may be
> prescribed for smoking cessation.
>
>
>
> Interactions:
>
> Carbamazepine: May decrease bupropion serum concentrations.
>
> Ritonavir: May increase bupropion serum concentrations increasing risk of
> toxicity.
>
> MAO inhibitors, selegiline: May increase risk of acute bupropion toxicity.
> Discontinue MAO inhibitors ≥ 14 days before starting bupropion.
>
> TCAs: TCA plasma concentrations may be elevated.
>
>
>
>
>
>
> Adverse Reactions:
>
> CNS:
> Abnormal thoughts; agitation; anxiety; depression; insomnia;
> irritability; hallucinations; somnolence; suicidal ideation; seizures;
> headache/migraine; tremor; nervousness; memory decreased;
> paresthesia; CNS stimulation; increased libido.
> CV:
> Edema; chest pain; flushing; hypertension; hot flashes; stroke;
> tachycardia; vasodilation; ECG abnormalities (eg, premature beats,
> nonspecific ST-T segment changes); MI.

 

Re: Extreme edema, Effexor withdrawal or Wellbutrin?

Posted by sl on May 24, 2001, at 12:54:38

In reply to Extreme edema, Effexor withdrawal or Wellbutrin?, posted by mvaureen on May 23, 2001, at 23:58:19


I'm confused. I thought I SAID that. But my post is gone again. :/

I said to contact your Dr, and even if he says not to worry perhaps he can get you some water-pills meanwhile.

sl

> I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

 

Re: Extreme edema, Effexor withdrawal or Wellbutrin?

Posted by sl on May 24, 2001, at 12:55:30

In reply to Re: Extreme edema, Effexor withdrawal or Wellbutrin?, posted by sl on May 24, 2001, at 12:54:38


*ROFL* This time it was YOUR bad, you posted twice! I answered one, and now I've answered both. :P

sl

> I'm confused. I thought I SAID that. But my post is gone again. :/
>
> I said to contact your Dr, and even if he says not to worry perhaps he can get you some water-pills meanwhile.
>
> sl
>
> > I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

 

Re: Extreme edema: call pdoc asap » Sulpicia

Posted by mvaureen on May 24, 2001, at 14:38:58

In reply to Re: Extreme edema: call pdoc asap » mvaureen, posted by Sulpicia on May 24, 2001, at 0:54:34

Thanks for the reply! If it's as simple as stopping Wellbutrin, okay.
I've been feeling what I think might be hypertensive. My p-doc seems
a bit uninformed about all of this. I actually saw him 12 hours before
I looked at my pained legs and saw the bloat [to put it lightly].
What I'd really like is the name of the site you tried to link me to. Do you still have it? Thanks again, Maureen. > >


> > I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?
>
> Hi--
> I don't know if this link is going to work -- oh damn. It's late here..
> The point here is that edema can be a sign of a allergic reaction to the wellbutrin, and a potentially serious one.
> Can your pdoc or clinician and report it.
> Now.
> Feel better soon.
> S.
> Browse Alphabetically
> A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
>
>
>
>
>
>
>
>
> Bupropion HCl
>
>
> (byoo-PRO-pee-ahn HIGH-droe-KLOR-ide)
>
>
> Action
> Indications
> Contraindications
> Route/Dosage
> Interactions
> Lab Test Interferences
>
> Adverse Reactions
> Precautions
> Patient Care Considerations
> Administration Storage
> Assessment/Interventions
> Patient/Family Education
>
>
> Trade Name(s):
>
> Wellbutrin
>
> Tablets, 75 mg
> Tablets, 100 mg
>
> Wellbutrin SR
>
> Tablets, sustained-release, 100 mg
> Tablets, sustained-release, 150 mg
>
> Zyban
>
> Tablets, sustained-release, 150 mg
>
> Indicates Canadian trade names.
>
> Class: Antidepressant/Smoking deterrent
>
>
>
> Action:
>
> Exact mechanism of antidepressant activity or as a smoking deterrent
> unknown; does not inhibit monoamine oxidase.
>
>
>
> Indications:
>
> Treatment of depression; aid to smoking cessation treatment.
>
>
>
> Contraindications:
>
> Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa;
> concurrent treatment with or within 14 days of discontinuation of MAO
> inhibitors; concurrent treatment with multiple bupropion products (eg,
> coadministration of Zyban for smoking cessation and Wellbutrin for
> depression).
>
>
>
> Route/Dosage:
>
> Antidepressant
> Adults: PO 100 mg bid initially; may increase to 100 mg tid after 3 days.
> Maximum daily dose 450 mg; maximum single dose 150 mg.
> Sustained release: 150 mg daily initially; may increase to 150 mg bid.
> Maximum daily dose 400 mg; maximum single dose 200 mg.
>
> Smoking Deterrent
> Adults: PO Initial dose: 150 mg for first 3 days increasing to 150 mg bid.
> Do not give doses > 300 mg/day. Initiate treatment while patient is still
> smoking. Patient should set target date to quit smoking within the first 2
> weeks of treatment; continue treatment for 7 to 12 weeks. Maintenance:
> Clinical data is not available regarding long-term treatment ( > 12 weeks)
> for smoking cessation. Whether to continue treatment must be
> determined for individual patients. Combination treatment: Combination
> treatment with bupropion and nicotine transdermal system may be
> prescribed for smoking cessation.
>
>
>
> Interactions:
>
> Carbamazepine: May decrease bupropion serum concentrations.
>
> Ritonavir: May increase bupropion serum concentrations increasing risk of
> toxicity.
>
> MAO inhibitors, selegiline: May increase risk of acute bupropion toxicity.
> Discontinue MAO inhibitors ≥ 14 days before starting bupropion.
>
> TCAs: TCA plasma concentrations may be elevated.
>
>
>
>
>
>
> Adverse Reactions:
>
> CNS:
> Abnormal thoughts; agitation; anxiety; depression; insomnia;
> irritability; hallucinations; somnolence; suicidal ideation; seizures;
> headache/migraine; tremor; nervousness; memory decreased;
> paresthesia; CNS stimulation; increased libido.
> CV:
> Edema; chest pain; flushing; hypertension; hot flashes; stroke;
> tachycardia; vasodilation; ECG abnormalities (eg, premature beats,
> nonspecific ST-T segment changes); MI.

 

Re: Extreme edema: URL » mvaureen

Posted by Sulpicia on May 24, 2001, at 16:28:58

In reply to Re: Extreme edema: call pdoc asap » Sulpicia, posted by mvaureen on May 24, 2001, at 14:38:58

> Ok, let's try this again
http://www.drugfacts.com/DrugFacts/home/home.jhtml?ps=pf=si=&user=G
On the left side, select A to Z drug facts.
Also check out the med interaction function.
Alternates:
the drug checker at Dr.Koop.com
Rxlist.com
also have look at some of Bob's links here.
I've found with pdrugs [and everything else] you've just
simply got to have the most detailed and up-to-date info
at hand. Tho I adore my docs, I don't expect them to spend
hours in the PDR -- it's my health after all. :)

The most amazing thing is probably the adverse event monitoring
database at the FDA site -- one for prescription meds and products,
and one for vitamins and supplements AND fully searchable.

Mind the OTC meds too and feel better soon.
S.

 

Re: Extreme edema, Effexor withdrawal or Wellbutrin?

Posted by sl on May 24, 2001, at 7:49:34

In reply to Extreme edema, Effexor withdrawal or Wellbutrin?, posted by mvaureen on May 23, 2001, at 23:58:22


I wouldn't blame it on the wellbutrin.
(but if you've ever read my posts, I LOVED Wellbutrin so I'd never blame it on that. :P)

That's a weird one, and you might want to talk to your Dr about water-pills at least til you're off the Effexor.

Good luck...
sl

> I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

 

Follow up: Extreme edema,...Wellbutrin?

Posted by mvaureen on May 24, 2001, at 14:28:50

In reply to Re: Extreme edema, Effexor withdrawal or Wellbutrin?, posted by sl on May 24, 2001, at 7:49:34

Hi,

Thanks for the responses! I hate to say that
I saw my p-doc yesterday, and he seemed baffled
by the edema. He gave me Lotensin HTC. After 24
hours, there's still no relief from the swelling.
I got really scared last night. I just wanted
to know why this is happening. I'm not really
jokingwhen I say it looks like Elephantitus. Could
this really be an allergic reaction? I'm so sad.
I've really liked the way Wellbutrin got me out of
the proverbial Effexor slumber. Of course, the edema
did begin when I started Wellbutrin. I wonder
why my p-doc doesn't know about this? He was shocked
at the list of 20 horrendous Effexor withdrawal
symptoms I gave him. Maybe I should seek another
doc. Too bad, I thought this PCP was the
right one for a change. I'm being completely honest
when I say that it was this board that got me
through the Effexor withdrawal. I read it often.
I'm off Effexor for 18 days now. Thank you for that!
And I hope to find answers about this edema. If
it weren't so nightmarishly bad, I'd say it was
worth it. I've got the Effexor weight, a lot of it, to
lose, so I'll have to take it all in. Which is
worse? Much thanks, Maureen

 

Re: Follow up: Extreme edema,...Wellbutrin? » mvaureen

Posted by Sulpicia on May 24, 2001, at 16:38:19

In reply to Follow up: Extreme edema,...Wellbutrin?, posted by mvaureen on May 24, 2001, at 14:28:50

> The pdoc is baffled????
To whom did he refer you to *unbaffle* himself, and when in
the next 12 hours is your appointment?
Look, I don't mean to be an alarmist here but you're either
demonstrating a serious circulatory problem or one hell of an allergy.
I'd feel a bit uncomfortable taking Lotensin without knowing *what*
I was taking it for.
Didn't he give you any diagnosis, or reason why he prescribed??
The edema is a symptom, not the problem....
Sorry to run on like this.
Are you any better currently?
S. aka the worrier.

 

Re: Extreme edema, Effexor withdrawal or Wellbutrin?

Posted by terra miller on May 24, 2001, at 23:24:38

In reply to Extreme edema, Effexor withdrawal or Wellbutrin?, posted by mvaureen on May 23, 2001, at 23:58:22

>
> I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

I had this reaction with serzone. My hands and feet, legs and arms swelled. I couldn't get up high enough to the therapeutic dose. But it's the wellbutrin. By the way, I am taking only wellbutrin now and I'm fine. See how meds effect people differently? Listen to your body. It really sounds like you're reacting to the wellbutrin.

take care, terra

 

Re: Extreme edema...Sulipiciaterra

Posted by mvaureen on May 25, 2001, at 13:19:13

In reply to Re: Extreme edema, Effexor withdrawal or Wellbutrin?, posted by terra miller on May 24, 2001, at 23:24:38


Hi!

I feel better and am not in a panic. Thanks for the feedback! It seems that the edema was from the Wellbutrin. I stopped taking it 24 hours ago, and ALL of my skin feels better. I feel a bit of nausea and headache, but I assume that as I felt that going on to Wellbutrin, I'll feel it going off. Anyway, I'm waiting to find out. I'm going on a weekend trip, and it seems that I'll have no AD's. This will be the first AD-free time in 3 years. My legs are already much better, and I can bend my fingers, toes, and ankles freely. The bright redness all over me is gone [I'd really not noticed I was that flushed]. Wow! I decided to let my doctor unbaffle himself and go for the information here and on the drug site. He didn't offer me a referral [and as my PCP, he's the boss of that], so I had to decide if going off Wellbutrin was as risky as Effexor. So far, all is good. I'm a little worried that three days from now I won't feel that way. It was on day three off of Effexor that the 2 week withdrawal nightmare began. I hope never to feel like that again. I was quite panicked by the time I decided not to continue Wellbutrin, and I really didn't want that to be the problem. The Lotensin is for losing water weight. My doc thought the swelling was because of my Effexor weight gain. He lectured me on not exercising enough. While I agree I must do more of that, I'm glad that this relief was quicker. I hope it continues. This board has once again helped me through a crisis! Thanks. I am learning what I see written here so many times -- to listen to my body.

 

Re: Extreme edema.. » mvaureen

Posted by Sulpicia on May 25, 2001, at 15:21:27

In reply to Re: Extreme edema...Sulipiciaterra, posted by mvaureen on May 25, 2001, at 13:19:13

>
> My doc thought the swelling was because of my Effexor weight gain. He lectured me on not exercising enough.

Hi -- very relieved that you're OK.
This might sound a bit presumptuous, especially since I'm not in your shoes,
but I find your doc's assessment troubling in light of your rather dramatic
symptoms...
I'm forever repeating the mantra "be guided by your clinician" but I have to ask:
is your doc pressed for time or perhaps dismissive of you as a patient?? You can tell
I'm looking for a polite periphrasis for the rather blunt question of his credentials/training/skills.
I realize that we all have to take control of our health and do our homework, and be our own advocates
but you experienced a potentially serious problem -- circulatory system involvement isn't like a rash
or something.
What will happen when you take another AD? It would be nice to know if there is something unique about
you that caused this response, especially so it can be prevented??
Can you go to the ER if something similar happens -- and the HMO can deal with it later?
Just thinking out loud.
Be well and good luck with your trip.
S.

 

Re: Extreme edema...Sulipiciaterra

Posted by sl on May 26, 2001, at 11:24:53

In reply to Re: Extreme edema...Sulipiciaterra, posted by mvaureen on May 25, 2001, at 13:19:13

>losing water weight. My doc thought the swelling was because of my Effexor weight gain. He lectured me on not exercising enough. While I

That worries me. He's not much of a Dr if he doesn't realize you couldn't put that much weight on that fast if you TRIED.

>agree I must do more of that, I'm glad that this relief was quicker. I hope it continues. This board has once again helped me through a crisis!

That might have been an annoyance and not a crisis if your Dr just listed to you....

>Thanks. I am learning what I see written here so many times -- to listen to my body.

EXACTLY!
I'm going to suggest you take some St John's Wort or other mood-elevating Over-the-counter. Or at least keep it on hand. Personally, when I go down I REALLY go down, and I wouldn't wanna be caught out in the cold. :/

sl

 

Follow-up:Extreme edema, etc...

Posted by mvaureen on May 28, 2001, at 16:51:15

In reply to Re: Extreme edema.. » mvaureen, posted by Sulpicia on May 25, 2001, at 15:21:27

Hi, and thanks, thanks, thanks! I made it through the mountain weekend, seemed to have stayed sane, and lost 7 pounds of water weight. I feel funny being AD-free, but I must admit that my body is thanking me. It has taken the worst treatment in all of this fighting against depression I've been doing. I'm going to have to switch p-docs I think. He's too busy. He lucked out on some things he did for me, but he can't remember my name, the side-effects of drugs, and he doesn't know the withdrawal symptoms of Effexor [a biggie not to know!]. Turns out I wasn't crazy, just depressed [tee hee]. Back in my shoes again! Maureen


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