Psycho-Babble Medication Thread 29738

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

Reboxetine Vestra

Posted by Missy on April 12, 2000, at 13:30:18

Greetings, I am very curious to hear more about the people who have taken Vestra (Reboxetine). I am anxious to try it when it comes out in the United States.

 

Re: Reboxetine Vestra

Posted by Andy on April 12, 2000, at 19:12:21

In reply to Reboxetine Vestra, posted by Missy on April 12, 2000, at 13:30:18

> Greetings, I am very curious to hear more about the people who have taken Vestra (Reboxetine). I am anxious to try it when it comes out in the United States.

I live in US and read about the stuff. Looked like a good alternative to some ssri side effects. Last summer me and my doc agreed to order from a european pharmacy (not cheap). I found it to be energizing, too energizing. Had some insomnia along with some constipation. The last straw was impotence (to men) which made me stop it. Didn't really give it a long enough trial to know its effectiveness. Just my experience.
andy

 

Re: Reboxetine Vestra

Posted by Cam W. on April 12, 2000, at 19:54:38

In reply to Re: Reboxetine Vestra, posted by Andy on April 12, 2000, at 19:12:21


Missy - I had a pdoc call me today and in the course of our conversation he said "Too bad about reboxetine, huh." I asked him to elaborate and he said he heard something about it's approval being denied for Canada. They are using as it an emergency release drug at our University Hospital (with quite a bit of success, too). I don't know if he was testing my knowledge on it, but because of this board, I was able to give a kind of intelligent answer. (You can never tell what a pdoc is really asking ;^) I think I impressed him. I will find out more tomarrow about the status of reboxetine in Canada. - Cam W.

 

Re: Reboxetine Vestra

Posted by Phil on April 12, 2000, at 20:07:09

In reply to Reboxetine Vestra, posted by Missy on April 12, 2000, at 13:30:18

It was way too energizing for me, too. And, I even started at half the recommended dose. I was REALLY excited about Reboxetine but from what I've seen posted here and elsewhere, it's success rate is average at best.
Still, it could be perfect for you.

Phil

 

Re: Reboxetine Vestra

Posted by kazoo on April 12, 2000, at 22:28:11

In reply to Reboxetine Vestra, posted by Missy on April 12, 2000, at 13:30:18

> Greetings, I am very curious to hear more about the people who have taken Vestra (Reboxetine). I am anxious to try it when it comes out in the United States.

^^^^^^^^^^^^
A word about Reboxetine's availability in the US: fuggettaboutit.
And you can thank Eli Lilly for kiboshing attempts to get it by the FDA.
Lilly has its *own* agenda for SNRIs, and not about to share it with
UPJOHN, so your health, and my health, and the health of the rest of this Goddamn
country don't mean SHIT TO A TREE, but Lilly's profits and stockholders do.
What they need is a "damn good whackin'" on the NYSE, not to mention a boycott of their
products.

Greetings to Missy.

kazoo

 

Re: Reboxetine Vestra

Posted by Luke on April 12, 2000, at 22:44:38

In reply to Reboxetine Vestra, posted by Missy on April 12, 2000, at 13:30:18

First time I've been here in a long time. Just thought I'd stop by, look for old friends ...
Anyway,saw the rebox entries. Reboxetine has been the most wonder AD for me. It has been a major tool in my putting my life back together after years of depression smashed it to pieces. I have experienced significant increases in confidence, motivation, self-esteem, energy. Significant decreases in addictive tendencies, wallowing, self-doubt, etc.
At first, the side effects were terrible - impotence, trouble urinating. But after about four or five months, they have gone away COMPLETELY.
That's been my experience. I wish it worked this way for everyone.
I also wish it would get approved in the US so i didn't have to spend so much money on it. But it's worth it for me.
Good luck,
Luke

 

Re: Reboxetine Vestra

Posted by JohnL on April 13, 2000, at 4:50:12

In reply to Reboxetine Vestra, posted by Missy on April 12, 2000, at 13:30:18

> Greetings, I am very curious to hear more about the people who have taken Vestra (Reboxetine). I am anxious to try it when it comes out in the United States.

I tried Reboxetine briefly. The immediate dramatic worsening of depression was too scary. Not to mention the anxiety, restlessness, insomnia, dry mouth, constipation, and total impotence. If someone's norepinephrine system is fine to begin with, Reboxetine will likely cause them lots of problems. If their norepinephrine system is deficient, then it will likely be helpful. But from what I've seen in statistics, norepinephrine faults make up a low percentage of cases.

In comparison, I found Desipramine far more effective on mood enhancement (no worsening either), and Nortriptyline somewhat helpful. But Desipramine was a stand out performer. Its side effects compared to Reboxetine were slightly less. It's hard to beat those time-tested tricyclics that have endured decades. They can have some unwanted side effects, but Reboxetine for me was much worse in every aspect imaginable. I think this effort to reinvent the wheel has resulted in a product not any better than the original wheel, and perhaps lacking in advantages of the original wheel. If Reboxetine never gets approved, I can understand why.

Since I've tried and compared various norepinephrine drugs, I would highly recommend someone try either Desipramine or Nortriptyline instead of Reboxetine. If you have ever had experience with stimulants, a positive mood response to Ritalin predicts a positive response to Desipramine. And a negative or neutral response to Ritalin predicts a positive response to Nortriptyline. I personally think Reboxetine has no advantage whatsoever over either of these two tricyclics. Any argument that Rebox has fewer side effects proved to be false with me. Those time-tested tricyclics--the gold standards of yesterday--are still the yardsticks for comparison, and I don't think Reboxetine measures up.

 

Re: Reboxetine Vestra

Posted by Missy on April 19, 2000, at 18:49:26

In reply to Re: Reboxetine Vestra, posted by JohnL on April 13, 2000, at 4:50:12

Thanks for the input! Luke I am happy that Reboxetine works for you. I am been taking effexor for quite a long time. Thus far it is the only drug that has worked at all for me besides tofranil which I had to stop taking because it drastically increased my heart rate. Effexor has helped me but it has only been minimal, and I have tried different dosages and switched to the xr. I tend to lack motivation and at times socializing with people seems to be a fear and very exhausting. The list of antidepressants I have tried is very long. I wonder if effexor can be taken with reboxetine, lol assuming it ever gets released in US????

Thanks!

 

Re: Reboxetine Vestra 'not approvable'

Posted by cromwell on May 22, 2001, at 15:25:30

In reply to Re: Reboxetine Vestra, posted by Missy on April 19, 2000, at 18:49:26

PEAPACK, N.J., May 18 /PRNewswire/ -- Pharmacia Corporation announced today that it has received a "not approvable" letter from the U.S. Food and Drug Administration (FDA) for VESTRA (reboxetine mesylate tablets), the company's investigational antidepressant. The company also announced that the FDA has agreed to convene an advisory committee meeting of outside experts later this year to review the VESTRA submission.

http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=105&STORY=/www/story/05-18-2001/0001497145

 

Re: Reboxetine Vestra 'not approvable' cromwell

Posted by kazoo on May 23, 2001, at 2:41:51

In reply to Re: Reboxetine Vestra 'not approvable', posted by cromwell on May 22, 2001, at 15:25:30

> PEAPACK, N.J., May 18 /PRNewswire/ -- Pharmacia Corporation announced today that it has received a "not approvable" letter from the U.S. Food and Drug Administration (FDA) for VESTRA (reboxetine mesylate tablets), the company's investigational antidepressant.
^^^^^^^^^
Gee, why doesn't this surprise me?

> The company also announced that the FDA has agreed to convene an advisory committee meeting of outside experts SHORTLY BEFORE YOU DIE to review the VESTRA submission.

The article isn't clear as to why it was deep-sixed. From what I gather, the thumbs-down was because of certain "clinical studies" abroad?

"Kazoo, would you like to study abroad?"
"Yes, teacher, I would like to study a broad."

Do I smell a rat in the Eli Lilly Corporation? I bet their stocks soared from this announcement.

(a studious) kazoo


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