Psycho-Babble Medication Thread 46548

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amisulpride: my final verdict

Posted by Sigolene on October 17, 2000, at 7:57:13

I tried amisulpride during 4 weeks, dosage 50, 100, 200 mg, for atypical depression, dysthymie.
Final verdict: no effect on me.
I'll switch to something else. I don't know what yet.
Sigolene.

 

Re: amisulpride: my final verdict

Posted by AndrewB on October 17, 2000, at 13:13:21

In reply to amisulpride: my final verdict, posted by Sigolene on October 17, 2000, at 7:57:13

What to try next?

I have no medical training, but if I were you I might try pramipexole (Mirapex). There is some evidence it works for atypical. I know it is availble in Italy without an Rx. It is a dopamine D2/D3 agonist. Didn't do anything for me but my pet theory is that it some of those who aren't helped by amisulpride are helped by Mirapex and visa versa.

It usually causes nausea and headaches at first so you slowly increase the dose. Start at 1/4 mg., take 3 times a day. As soon as side effects subside, increase the dose 1/4mg. to 1/2 mg. at a time. Final effective dose may be as high as 5mg./day. Cheapest when bought in 1mg. or 1.5mg tablet dosages but smaller dosage pills are more convenient when starting out. It should kick in farily quickly once you reach the effective dose, not more than 2 weeks I would think. Kind of expensive. I found the side effects to go away quickly.

What are you thinking about trying next/

AndrewB

 

Re: amisulpride: my final verdict

Posted by JohnL on October 18, 2000, at 3:52:02

In reply to amisulpride: my final verdict, posted by Sigolene on October 17, 2000, at 7:57:13

> I tried amisulpride during 4 weeks, dosage 50, 100, 200 mg, for atypical depression, dysthymie.
> Final verdict: no effect on me.
> I'll switch to something else. I don't know what yet.
> Sigolene.

Sorry it didn't work out for you Sigolene. With the benefit of hindsight, I must admit I would have tried adding Adrafinil to it before abandoning it. But if you haven't tried Adrafinil, it could be a good option. Maybe the chemistry underlying your symptoms is not dopamine related, and thus the failure of Amisulpride to do anything. Maybe take a look at norepinephrine instead, which Adrafinil will turbocharge.
John


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