Psycho-Babble Medication Thread 46142

Shown: posts 1 to 8 of 8. This is the beginning of the thread.

 

Treatment Resisitive Depression, any help out ther

Posted by blue5150 on October 11, 2000, at 18:42:41

I have been diagnosed with treatment resistive depression. Over the past 4+ years, I have tried almost all antidepression drugs available. I never get any benifits or side effects, no matter which drug, combination of drugs, or dosage. My Dr. now wants me to talk to another Dr. about ECT. I don't know very much about ECT but that sounds like it would be a last resort. Does anyone know of any other treatments available for TRD?

 

Re: Treatment Resistive Depression, any help out ther

Posted by Cindy W on October 11, 2000, at 22:01:39

In reply to Treatment Resisitive Depression, any help out ther, posted by blue5150 on October 11, 2000, at 18:42:41

> I have been diagnosed with treatment resistive depression. Over the past 4+ years, I have tried almost all antidepression drugs available. I never get any benifits or side effects, no matter which drug, combination of drugs, or dosage. My Dr. now wants me to talk to another Dr. about ECT. I don't know very much about ECT but that sounds like it would be a last resort. Does anyone know of any other treatments available for TRD?

blue5150, don't know what AD's you tried. Other possible modalities include cognitive behavior therapy (shown to be very effective) and sleep deprivation (apparently it really reduces depression, for some people with TRD). There are various types of depression, and individuals respond differently to various AD's and treatments. If you could be a little more specific about what's going on with you, we could probably offer more suggestions. Is your depression dysthymia, or major depression, or bipolar type, or atypical depression? How have you responded to various AD's? Is your depression characterized by vegetative signs (sleep and appetite disturbances, lack of energy, psychomotor retardation, etc.) or depressive core beliefs (I'm rotten, the world is a bad place, things will never improve)? Do you have ups as well as downs? How far down do you go (do you think about suicide or wish you were not alive, or just hope things would get better so the pain will stop?). There are so many treatments and meds nowdays that ECT is usually a last resort, from what I understand. Have you tried tricyclics; tetracyclics; SSRI's; new atypical AD's such as Serzone, Remeron, Effexor-XR; MAO inhibitors? Hope things start getting better for you. A lot of people have "been there" on this board and hopefully can give you some suggestions for various treatments.--Cindy W (I take Effexor-XR, Serzone, and Seroquel, and am doing self-help cognitive behavior therapy since there are LOT of materials available for this; plus I see a pdoc every month for med management and for psychotherapy).

 

Re: Treatment Resisitive Depression, any help out ther

Posted by stjames on October 11, 2000, at 22:12:17

In reply to Treatment Resisitive Depression, any help out ther, posted by blue5150 on October 11, 2000, at 18:42:41

> I have been diagnosed with treatment resistive depression. Over the past 4+ years, I have tried almost all antidepression drugs available.

James here.....

Could you list the meds you have tried and if any were of any benifit ?

james

 

Re: Treatment Resisitive Depression, any help out ther

Posted by noa on October 12, 2000, at 15:20:36

In reply to Re: Treatment Resisitive Depression, any help out ther, posted by stjames on October 11, 2000, at 22:12:17

Yes, please list types of symptoms, as Cindy says, and meds tried.

There are sometimes other things going on, like endocrine problems, or sleep disorders, for example, that need to be evaluated, too.

 

Re: Treatment Resisitive Depression, any help out ther

Posted by salarmy4me on October 14, 2000, at 3:27:54

In reply to Treatment Resisitive Depression, any help out ther, posted by blue5150 on October 11, 2000, at 18:42:41

> I have been diagnosed with treatment resistive depression. Over the past 4+ years, I have tried almost all antidepression drugs available. I never get any benifits or side effects, no matter which drug, combination of drugs, or dosage. My Dr. now wants me to talk to another Dr. about ECT. I don't know very much about ECT but that sounds like it would be a last resort. Does anyone know of any other treatments available for TRD?

Try MAOIs

 

Re: Treatment Resistive Depression, any help out ther

Posted by blue5150 on October 16, 2000, at 0:17:45

In reply to Re: Treatment Resistive Depression, any help out ther, posted by Cindy W on October 11, 2000, at 22:01:39

> > I have been diagnosed with treatment resistive depression. Over the past 4+ years, I have tried almost all antidepression drugs available. I never get any benifits or side effects, no matter which drug, combination of drugs, or dosage. My Dr. now wants me to talk to another Dr. about ECT. I don't know very much about ECT but that sounds like it would be a last resort. Does anyone know of any other treatments available for TRD?
>
> blue5150, don't know what AD's you tried. Other possible modalities include cognitive behavior therapy (shown to be very effective) and sleep deprivation (apparently it really reduces depression, for some people with TRD). There are various types of depression, and individuals respond differently to various AD's and treatments. If you could be a little more specific about what's going on with you, we could probably offer more suggestions. Is your depression dysthymia, or major depression, or bipolar type, or atypical depression? How have you responded to various AD's? Is your depression characterized by vegetative signs (sleep and appetite disturbances, lack of energy, psychomotor retardation, etc.) or depressive core beliefs (I'm rotten, the world is a bad place, things will never improve)? Do you have ups as well as downs? How far down do you go (do you think about suicide or wish you were not alive, or just hope things would get better so the pain will stop?). There are so many treatments and meds nowdays that ECT is usually a last resort, from what I understand. Have you tried tricyclics; tetracyclics; SSRI's; new atypical AD's such as Serzone, Remeron, Effexor-XR; MAO inhibitors? Hope things start getting better for you. A lot of people have "been there" on this board and hopefully can give you some suggestions for various treatments.--Cindy W (I take Effexor-XR, Serzone, and Seroquel, and am doing self-help cognitive behavior therapy since there are LOT of materials available for this; plus I see a pdoc every month for med management and for psychotherapy).

CindyW, thanks for responding. I will try to answer the questions you asked. I have dysthymia with major depression. My symptions are of the vegetative-type along with hopelessness and severe emotional pain. I have tried suicide once before but haven't had any suicidal thoughts recently except for the thought of it not being if, but when, I will take my life. This scares me. I never feel any "highs" and vary between "a 2 and a 4". The drugs I have been on are: Prozac, Effexor, Paxil, Celexa, Zoloft, Doxepin, Parnate, Wellbutrin, Remeron, Serzone and Trazadone. The only one I had any response with was side effects only with Parnate. I also have lots of anxiety with panic attacts sometimes and I have started to stutter the last 4 mos., with it getting increasingly worse. It is helpful to hear that there are other alternative treatments available. I hope (someday, before it's too late) I can find something that will work for me.

 

Re: Treatment Resisitive Depression, any help out ther

Posted by MA on October 16, 2000, at 12:45:20

In reply to Re: Treatment Resisitive Depression, any help out ther, posted by noa on October 12, 2000, at 15:20:36

Hi, I just found this today and it seems to be pertinent to the topic, so here is the website.

www.medscape.com/treatment/resistant-depression

 

Re: Treatment Resisitive Depression, any help out ther

Posted by Diane E. on October 16, 2000, at 15:49:40

In reply to Re: Treatment Resisitive Depression, any help out ther, posted by noa on October 12, 2000, at 15:20:36

My husband, who is very treatment-resistant, is considering participating in a research study using
Vagus Nerve Stimulation (an implanted device that is currently used for epilepsy and may have
anti-depressive effects). 40% of people with severe tx-resistant depression improved with this
device in the first study....which isn't bad given how many other therapies these people had
tried (see http://www.bcm.tmc.edu/psych/mdoc/research/vnsdo1.pdf). There are
20 study sites throughout the country (http://www.cyberonics.com/Depression/default.htm).

Good luck.
-Diane


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