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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Diane on December 14, 1999, at 11:00:19
" DMAE
DMAE, (Dimethylaminoethanol) is a nutritional supplement that
supports the old wives' tale that fish is a great brain food. DMAE is
normally present in small amounts in our brains, and is known for its
mental stimulation and enhancement.
Because fish is naturally abundant in DMAE, a diet high in sardines
and anchovies will provide higher than average levels of DMAE and
choline to the brain, which serve as raw materials for the production of
the neurotransmitter acetylcholine. Acetylcholine is responsible for
conducting nerve impulses within the brain, and by accelerating the
brain's synthesis of this important neurotransmitter, DMAE may aid in
improving memory and learning, as well as preventing loss of memory
in adults.DMAE helps elevate mood, improve memory and learning, increase
intelligence and physical energy, and extends the life span of
laboratory animals1. It is used by many people for its mild, safe
stimulant effect, yet DMAE also makes it easier for most people to get
to sleep. Many people report less fatigue in the day and sounder sleep
at night, as well as needing less sleep when taking DMAE.The stimulant effect of DMAE is significantly different from the
stimulation produced by coffee, amphetamines, or other stimulant
drugs. DMAE does not have a drug-like quick up and down. People
who take DMAE have reported that they feel a mild stimulation
continually, without side effects. Many athletes using DMAE report an
improved energy output in addition to better concentration on form and
technique. Also, when DMAE use is discontinued, no depression or
let-down occurs. SMART Basics DMAE includes 150 mg B-5, along
with other B vitamins to support the activity of DMAE. "
http://www.smartbasic.com/glos.nutrients/dmae.glos.html
Posted by Adam on December 14, 1999, at 13:49:09
In reply to DMAE, posted by Diane on December 14, 1999, at 11:00:19
Umm, that's interesting. Are you taking DMAE? Do you feel it is helpful?
> " DMAE
>
> DMAE, (Dimethylaminoethanol) is a nutritional supplement that
> supports the old wives' tale that fish is a great brain food. DMAE is
> normally present in small amounts in our brains, and is known for its
> mental stimulation and enhancement.
> Because fish is naturally abundant in DMAE, a diet high in sardines
> and anchovies will provide higher than average levels of DMAE and
> choline to the brain, which serve as raw materials for the production of
> the neurotransmitter acetylcholine. Acetylcholine is responsible for
> conducting nerve impulses within the brain, and by accelerating the
> brain's synthesis of this important neurotransmitter, DMAE may aid in
> improving memory and learning, as well as preventing loss of memory
> in adults.
>
> DMAE helps elevate mood, improve memory and learning, increase
> intelligence and physical energy, and extends the life span of
> laboratory animals1. It is used by many people for its mild, safe
> stimulant effect, yet DMAE also makes it easier for most people to get
> to sleep. Many people report less fatigue in the day and sounder sleep
> at night, as well as needing less sleep when taking DMAE.
>
> The stimulant effect of DMAE is significantly different from the
> stimulation produced by coffee, amphetamines, or other stimulant
> drugs. DMAE does not have a drug-like quick up and down. People
> who take DMAE have reported that they feel a mild stimulation
> continually, without side effects. Many athletes using DMAE report an
> improved energy output in addition to better concentration on form and
> technique. Also, when DMAE use is discontinued, no depression or
> let-down occurs. SMART Basics DMAE includes 150 mg B-5, along
> with other B vitamins to support the activity of DMAE. "
>
> http://www.smartbasic.com/glos.nutrients/dmae.glos.html
Posted by Diane on December 14, 1999, at 18:03:42
In reply to Re: DMAE, posted by Adam on December 14, 1999, at 13:49:09
> Umm, that's interesting. Are you taking DMAE? Do you feel it is helpful?
No I am not taking DMAE as yet (I have it on order tho).
I live in a very small town with one small health food store. I was surprised they had
Inositol powder & DHEA. I just bought their last two bottles today after reading
your posting about Inositol ( Inositol Adam 12/9/99).----------I like this study on Inositol
Acute myo-inositol enhances swimming activity in goldfish
by
Levine J, Chengappa KN, Reddy R
Stanely Center for the Innovative Treatment of Bipolar Disorder,
Western Psychiatric Institute &
Clinic, Pittsburgh, PA 15213, USA.
J Neural Transm 1999; 106(5-6): 433-41ABSTRACT
Inositol in concentrations of 1-4 Mm (but not the control condition: mannitol-glucose)
administered in aquarium water showed enhancement of swimming activity of goldfish
after acute treatment (5 hours). These data support similar findings in rats. These data
suggest that inositol may enhance motor activity which may be of relevance in
neuropsychiatric disorders.
Future studies of the effects of lithium on this activity, and its potential reversal by inositol
may shed light on the possible involvement of the phosphatidyl-inositol second
messenger system in this behavior.
------- :o) crazy eh?I'm just rooting around, while I work up the courage to ask my GP if he'll prescribe me
Buprenorphine, for stuff that has possibilities, is easily obtainable, relatively side-effect
free, non-toxic.
I need something to give my GP that will sell him dead bang on Buprenorphine. So far
I've only come up with one abstract "Buprenorphine treatment of refractory depression"
I need more.
As with methadone tho, the only studies done on Buprenorphine relate to drug abuse
treatment.Catch you later Adam.
Posted by Adam on December 14, 1999, at 19:17:01
In reply to Re: DMAE, posted by Diane on December 14, 1999, at 18:03:42
As far as I know, that paper on buprenorphine is the only one out there. The first author is
the chief investigator of the selegiline study I am currently enrolled in. His name is J. Alexander
Bodkin, and works in McLean Hospital in Belmont, MA. Maybe your doctor can look him up.Good luck. Let me know how the inositol and DHEA work out for you. I have to admit, I've read
about a lot of the supplements and herbal remedies (SJW, inostitol, other B vitamins, SAMe) with
some incredulity. Perhaps that is a bias toward the more "established" remedies of allopathic
medicine; I may be guilty of faith in the products of pharmaceutical companies to the point that
I have ignored less flashy compounds. But if some "supplements" hold up to the same scrutiny that
other pharmacological agents do, and they're easier to tolerate, then that's some cause for
optimism.
> I'm just rooting around, while I work up the courage to ask my GP if he'll prescribe me
> Buprenorphine, for stuff that has possibilities, is easily obtainable, relatively side-effect
> free, non-toxic.
> I need something to give my GP that will sell him dead bang on Buprenorphine. So far
> I've only come up with one abstract "Buprenorphine treatment of refractory depression"
> I need more.
> As with methadone tho, the only studies done on Buprenorphine relate to drug abuse
> treatment.
>
> Catch you later Adam.
Posted by MaTurtle on December 15, 2003, at 18:14:06
In reply to Re: DMAE, posted by Adam on December 14, 1999, at 19:17:01
There is a newer study saying that dmae decreased the life-span of labrotory animals... there is not much research on the effects of dmae supplementation so it could be due to other factors but anyway quote from erowid.org
-----
""Deaner" and "Deanol" were the registered names of prescription drugs that contain dimethylaminoethanol (DMAE), thought to be a precursor of acetylcholine. Like choline, DMAE has been used to treat various disorders of the nervous system. It appears to have a beneficial role in the treatment of tardive dyskinesia and Huntington's chorea. There is no support, however, for recent claims that DMAE is a potent life extender that might benefit the general population. The life spans of some animals were reported to have been extended through DMAE supplementation, but a more recent study not only failed to confirm this, but found the opposite to be true. Deanol-treated animals actually had shorter life spans than control animals that did not receive this substance. Some have noted the relationship of DMAE to Gerovital H3, one of the breakdown products of which is diethylaminoethanol (DEAE), a close chemical relative. If DMAE has any efficacy at all it appears likely that this is due to its role as a choline precursor in the liver. The choline synthesized in the liver from DMAE can go to the brain via the blood and may play a role in the regulation of acetylcholine there. No such role can be conceived of for DEAE. Deaner is no longer a prescription drug and is now sold in some health food stores. It certainly should not be used as a dietary supplement, as some "life extension" enthusiasts have suggested."
-------
hope this info clears up some of the false and untested claims you can find on websites trying to sell dmae...
Posted by MaTurtle on December 15, 2003, at 18:36:47
In reply to Re: DMAE, posted by Adam on December 14, 1999, at 19:17:01
actually here is the specific study that I was talking about... taken from http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=830732&dopt=Abstract
---
1: J Gerontol. 1977 Jan;32(1):38-45."Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail.
Cherkin A, Exkardt MJ.
The lysosome hypothesis of aging predicts that membrane stabilizers will extend life-span. Stabilizers containing the dimethylaminoethanol moiety (DMAE) have been reported to extend the life-span of drosophila and mice. We tested the prediction in Japanese quail (N = 15) by administering DMAE bitartrate (18.4 mg/kg/day) in the drinking water for 69 weeks, starting at 195 weeks of age. A matched control group (N = 14) received tartaric acid (4.0 mg/kg/day) in the water. Contrary to the prediction, the DMAE-treated group has a shorter life-span after start of treatment (49 weeks) than the controls (69 weeks). No significant differences between the groups were observed in body weight or daily fluid intake. Three behavioral studies were carried out on survivors at 243-249 weeks of age, namely; activity response to light-flash; sexual mounting response to a female quail; and classical conditioning of the heart rate. Aged quail differed from young-adults in changes in motor activity in response to light flashes. Aged quail appeared less responsive initially to reinforced conditioning trials and demonstrated extinction when light flash was not followed by electric shock. There were no detectable differences in latency to mount or in basal heart rate, either as a function of age or as a function of DMAE treatment.
PMID: 830732 [PubMed - indexed for MEDLINE]"
----------
Posted by Dr. Bob on December 16, 2003, at 7:59:06
In reply to Re: DMAE, posted by MaTurtle on December 15, 2003, at 18:14:06
> There is a newer study saying that dmae decreased the life-span of labrotory animals... there is not much research on the effects of dm
Sorry if it's confusing, but Psycho-Babble Alternative is now the board for discussion of alternative treatments. Here's a link:
http://www.dr-bob.org/babble/alter/20031204/msgs/290422.html
Thanks,
Bob
This is the end of the thread.
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