Psycho-Babble Medication Thread 15615

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Trazadone & priapism

Posted by Max on November 21, 1999, at 21:03:06

Is there any possibility that trazadone can produce an "arousal" state in females?

 

Re: Trazadone & priapism

Posted by Scott L. Schofield on November 22, 1999, at 8:31:03

In reply to Trazadone & priapism, posted by Max on November 21, 1999, at 21:03:06

> Is there any possibility that trazadone can produce an "arousal" state in females?

I will leave for someone more qualified than I to answer that question. However, your subject description raises a very important issue. Trazadone can cause priapism in males. Priapism is the occurrance of a painful and continual erection that is to be regarded as a serious side-effect. I don't know how prevalent it is, but I haven't run across any first-hand accounts.


- Scott

 

Trazadone & priapism QUALIFIED PERSONS, PLEASE

Posted by MAX on November 22, 1999, at 21:27:02

In reply to Re: Trazadone & priapism, posted by Scott L. Schofield on November 22, 1999, at 8:31:03

If I were male, I think it would qualify as priapism! This constant "arousal" is making me nuts. I have been to the gynecoligist who says I have no infections. QUALIFIED PERSONS, WHERE ARE YOU??? ANSWER, ANSWER PLEASE. Dr. Bob?

 

Re: Trazodone & priapism

Posted by Dr. Bob on November 23, 1999, at 21:14:33

In reply to Trazadone & priapism QUALIFIED PERSONS, PLEASE, posted by MAX on November 22, 1999, at 21:27:02

> If I were male, I think it would qualify as priapism! This constant "arousal" is making me nuts. I have been to the gynecoligist who says I have no infections.

In fact, I don't think priapism is associated with sexual arousal. If it's making you nuts, then it might be a good idea to cut back on it. Probably it makes sense to talk to whoever prescribed it. It wasn't your gynecologist, was it?

Bob

 

Re: Trazodone & priapism

Posted by Jane on November 25, 1999, at 0:38:43

In reply to Re: Trazodone & priapism, posted by Dr. Bob on November 23, 1999, at 21:14:33

priapism is not linked to "sexual arousal" the way we think of it, i agree with dr. bob. you may be experiencing a rare side effect of trazodone - this requires you to visit your doctor because s/he needs to know about this - priapism is sometimes (although rare) associated with medication therapies.
jane

 

Re: Trazodone & priapism

Posted by Alyse on November 25, 1999, at 11:09:01

In reply to Re: Trazodone & priapism, posted by Dr. Bob on November 23, 1999, at 21:14:33

My Psychiatrist prescribed it. He says he doesn't know what is going on. May not be the Traz. Have made an appt with my Gyn. I sure appreciate your message reply. Thanks a lot.

 

Re: Trazadone & priapism QUALIFIED PERSONS, PLEASE

Posted by Scott L. Schofield on November 25, 1999, at 11:19:03

In reply to Trazadone & priapism QUALIFIED PERSONS, PLEASE, posted by MAX on November 22, 1999, at 21:27:02

Oral trazodone is not effective therapy for erectile dysfunction: a double-blind, placebo controlled trial.

Costabile RA, Spevak M
Department of Surgery, Uniformed Services University, Walter Reed Army Medical Center, Washington, D.C., USA.

PURPOSE: The unusual side effect of priapism associated with the antidepressant trazodone has led researchers to evaluate its use for the treatment of erectile dysfunction. Previous studies have shown nearly 70% efficacy in patients. Unfortunately, these studies have been anecdotal, retrospective or of combination therapy with yohimbine. A placebo controlled, fixed dose, double-blind crossover study was performed to evaluate the safety and efficacy of oral trazodone for the treatment of erectile dysfunction. MATERIALS AND METHODS: A total of 51 patients with at least 3 months of complete erectile dysfunction were randomized in a double-blind fashion to receive 50 mg. trazodone or placebo at bedtime. Evaluation consisted of a history, physical examination and laboratory studies, including hormonal evaluation, nocturnal penile tumescence evaluation, penile Doppler ultrasound and the Index of Sexual Satisfaction. Patients were followed at monthly intervals with an in clinic interview. After a 3-month treatment interval patients were reevaluated with index scores and crossed over after a 3-week washout period. Study end points included patient diary evaluations and index scores at the beginning of the study interval and the end of the first treatment period. RESULTS: Of the 51 patients who enrolled in the study 48 completed both phases. Mean patient age was 65 years (range 31 to 80). After the first 3-month treatment interval 19% of patients receiving trazodone had improved erections compared to 24% receiving placebo (p < 0.50). Of the trazodone group 35% had improvement in sex drive compared to 20% of the placebo group (p < 0.36). Mean Index of Sexual Satisfaction scores changed after treatment from 31.7 to 27.5 for the trazodone group (p < 0.50) and from 28.5 to 30.8 for the placebo group (p < 0.49). Side effects included drowsiness in 31% of the patients, dry mouth in 1% and fatigue in 19%. CONCLUSIONS: Trazodone is no more effective than placebo in improving erections and sexual function in patients with severe physiological erectile dysfunction.

Publication Types:


Clinical trial
Randomized controlled trial
PMID: 10332444, UI: 99264848

 

Re: Trazodone & priapism

Posted by Max on November 25, 1999, at 11:52:58

In reply to Re: Trazodone & priapism, posted by Dr. Bob on November 23, 1999, at 21:14:33

> > If I were male, I think it would qualify as priapism! This constant "arousal" is making me nuts. I have been to the gynecoligist who says I have no infections.
>
> In fact, I don't think priapism is associated with sexual arousal. If it's making you nuts, then it might be a good idea to cut back on it. Probably it makes sense to talk to whoever prescribed it. It wasn't your gynecologist, was it?
>
> Bob

It wasn't, though I will be going there VERY soon. Appreciate the expert input. Be well.

 

Re: Trazodone & priapism

Posted by Susan on December 8, 1999, at 19:07:43

In reply to Re: Trazodone & priapism, posted by Max on November 25, 1999, at 11:52:58

> > > If I were male, I think it would qualify as priapism! This constant "arousal" is making me nuts. I have been to the gynecoligist who says I have no infections.
> >
> > In fact, I don't think priapism is associated with sexual arousal. If it's making you nuts, then it might be a good idea to cut back on it. Probably it makes sense to talk to whoever prescribed it. It wasn't your gynecologist, was it?
> >
> > Bob
>
> It wasn't, though I will be going there VERY soon. Appreciate the expert input. Be well.

Boy, does this sound familiar. About three years ago, I began taking Trazodone 150 mg. First time I had taken antidepressants of any kind. Within a couple of weeks not only did I begin feeling much better (better than I had felt in many years, in fact), but I was sexually crazed after having virtually no sex drive for many, many months prior. I searched but couldn't find any literature anywhere that talked about this particular side effect. My doctor, too, was baffled (and amused). Unfortunately, after taking the drug for nine months or so it stopped working completely, and I haven't been able to find an effective antidepressant since. I recently began taking Trazodone again. So far, no side effects but then, it doesn't seem to be having any effect of any kind yet.


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