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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by CHRIS on November 1, 1999, at 10:37:16
i've been taking 600mg moclobemide (Manerix) for the
last four weeks. It has really helped with social
anxiety (I suffer from social phobia) but not so much
with depression.
PLEASE somebody reply and let me know if anything else
will help be it an increase in dose, extra SSRI or
whatever.
I`ve been on loads of different meds and tried loads of
different therapies but this has been the best yet.
I do still feel depressed though.
Posted by JohnL on November 1, 1999, at 17:09:56
In reply to MOCLOBEMIDE, posted by CHRIS on November 1, 1999, at 10:37:16
Hi Chris. With caution and your doctor's participation you can indeed add another AD to the Moclobemide. Even though SSRIs have been combined with Moclobemide, they probably need more caution. Very low doses to start and feel it out as you go. A safer addition would be one of the TCAs, since they aren't so serotonin-specific. Thus less likelihood of an adverse serotonin reaction. Desipramine would be a good first choice. Or Nortriptyline. They do have more side effects than Moclobemide, but hopefully it wouldn't take much of a dose to kickstart the Moclobemide. Wellbutrin would probably be good too and maybe the safest of all. If you can get it.
But the most logical thing to me would be increasing the dose. Are you handling side effects OK? If so, try going up to 800mg - 900mg. I knew a person who took 1200mg, even though that is way over the max level. But for her it worked great where lower doses didn't, and she had no problem with it.
In general it seems Moclobemide is one of those drugs that really needs to be at a maximum dose to be real effective. Some of the clinical studies that showed disappointing results were in the 300mg to 600mg range. The clinical studies that did not disappoint were in the 900mg area. Great results at highest doses. Are you handling side effects OK? Consider raising the dose? It's a good sign that it has worked better than other things for you so far. Simply raising the dose might be all you need. 600mg isn't very high for Moclobemide.
Posted by mat stone on November 1, 1999, at 19:19:05
In reply to MOCLOBEMIDE, posted by CHRIS on November 1, 1999, at 10:37:16
My word Chris! I start on 300mg of moclobemide tomorrow. I suffer from social phobia and this in turn i believe causes me to feel depressed (i think). I've been treated with prozac and effexor with no change so far.
May I ask how you feel your social phobia has lessened? You feel calmer? You feel more energized?
Did you start on 300mg? Did the jump up to 600mg make all the difference?
You've got me very excited Chris
Posted by JohnL on November 2, 1999, at 3:09:55
In reply to moclobemide works for socail phobia?, posted by mat stone on November 1, 1999, at 19:19:05
Hi Mat. I just finished reading a lot of stuff on Moclobemide. It is used successfully for social phobia. Seemed like there were more clinical studies for that than for depression. Anyway, it has been used frequently for tht purpose and is generally very effective though generally not quite as robust as the real MAOIs. And as I mentioned in my previous post, the step up from 600mg to 900mg makes a huge difference according to anecdotal evidence in the field. Some go as high as 1200mg.
As far as your starting dose, a good rule of thumb is take what's bearable (75mg? 150mg? 300mg?). Get used to any side effects for a few days before increasing the dose. Moclobemide by the way can be cut or split into smaller pieces for custom dosing.
Posted by mat stone on November 2, 1999, at 13:22:28
In reply to Re: moclobemide works for socail phobia?, posted by JohnL on November 2, 1999, at 3:09:55
John L
I know it isn't an easy question to answer, but how would you say the moclobemide has effected you? Any answer would be gratefully recieved.
I always group the effects of meds as either uppers or downers, is this relevant to moclobemide?
Thanks John
Posted by JohnL on November 2, 1999, at 15:27:02
In reply to Re: moclobemide works for socail phobia?, posted by mat stone on November 2, 1999, at 13:22:28
> John L
>
> I know it isn't an easy question to answer, but how would you say the moclobemide has effected you?I don't use Moclobemide.
>
> I always group the effects of meds as either uppers or downers, is this relevant to moclobemide?In literature it seems rather neutral. Not really upper or downer. We're all different though. One thing for sure though is that at higher doses (750mg-900mg) a common side effect mentioned is psychic activation and psychomotor activation. In other words, it's more like an upper when used at high doses. Just have to try it and see.
Posted by mat stone on November 3, 1999, at 12:46:02
In reply to Re: moclobemide works for socail phobia?, posted by mat stone on November 2, 1999, at 13:22:28
Chris is there anything you can tell me about moclomemide's effects? I started it yesterday (300mg). Any info would be great. email me if you prefer
matleestone@hotmail.com
mathew
Posted by jamie on November 3, 1999, at 14:56:11
In reply to Chris r u there?, posted by mat stone on November 3, 1999, at 12:46:02
> Chris is there anything you can tell me about moclomemide's effects? I started it yesterday (300mg). Any info would be great. email me if you prefer
>
> matleestone@hotmail.com
>
> mathewIf you are asking about moclobemide side effects, they are supposed to be about as low as it gets for an AD. Early on you could experience any number of things. But long term it is supposed to be very user friendly. This has special implications for senior citizens. Or for someone experiencing sexual dysfunction on a different AD. Or anyone sensitive to side effects in general.
Posted by mat stone on November 3, 1999, at 15:58:27
In reply to Re: Not Chris, but..., posted by jamie on November 3, 1999, at 14:56:11
Thanks Jamie, but actually I'm not too concerned about the side effects, nothing ever seems to be effect me bad that way and as for sexual dysfunction, well when I feel better mentally, then I'll worry about my (still born) sex life.
No actually Chris (u there?) said the moclobemide had helped with his social phobia and I wanted to know if he could go into more detail on this subjest.
ie. does it make him feel more relaxed? more energised?This is of very special interest to me
mathew
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