Psycho-Babble Medication Thread 6498

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simplistic hypotheses about drug mechanisms

Posted by Pavel on May 25, 1999, at 11:16:40

In theory, would a beta-adrenergic blocker block the peripheral stimulation of CNS stimulants such as Ritalin, while leaving its effects on the brain unhindered?

I take Ritalin for ADD but don't enjoy the peripheral effects on my cardiovascular system. It seems that beta-blockers would cancel out these peripheral effects. Is my thinking correct?

How about other stimulants such as ephedrine? Since epedrine's effects are primarily peripheral, would a beta-blocker cancel out these effects, netting in an effect in the brain only?

This I ask just out of curiosity, to see if I understand these drug mechanisms clearly.

 

Re: simplistic hypotheses about drug mechanisms

Posted by saintjames on May 26, 1999, at 1:29:40

In reply to simplistic hypotheses about drug mechanisms, posted by Pavel on May 25, 1999, at 11:16:40

> In theory, would a beta-adrenergic blocker block the peripheral stimulation of CNS stimulants such as Ritalin, while leaving its effects on the brain unhindered?


James here...

I take Inderal for this reason, as I take Dexadrine. But only as needed (once or twice a month) The beta blockers can cause depression
and create asthma in people where it does not exist prior.

Perhaps a different dose or different stim would
have less of this effect so a beta blocker would not be needed.


james



 

Re: simplistic hypotheses about drug mechanisms

Posted by Jeff on May 26, 1999, at 12:53:31

In reply to simplistic hypotheses about drug mechanisms, posted by Pavel on May 25, 1999, at 11:16:40

> In theory, would a beta-adrenergic blocker block the peripheral stimulation of CNS stimulants such as Ritalin, while leaving its effects on the brain unhindered?
>
> I take Ritalin for ADD but don't enjoy the peripheral effects on my cardiovascular system. It seems that beta-blockers would cancel out these peripheral effects. Is my thinking correct?
>
> How about other stimulants such as ephedrine? Since epedrine's effects are primarily peripheral, would a beta-blocker cancel out these effects, netting in an effect in the brain only?
>
> This I ask just out of curiosity, to see if I understand these drug mechanisms clearly.

Are you taking name brand Ritalin or the generic equivalent Methylphenidate? I ask because I had lots of problems with the generic like irregular heartbeat, and heart pounding. Switching to the name brand completely removed these side effects, and I know that it wasn't just in my head because I have to pay 25% of cost for non-generics on my health plan.

 

Re: simplistic hypotheses about drug mechanisms

Posted by alan on May 27, 1999, at 20:28:04

In reply to Re: simplistic hypotheses about drug mechanisms, posted by Jeff on May 26, 1999, at 12:53:31

a simplistic addendum: Use beta-blockers that are supposed to not cross the blood-brain barrier and enter the CNS.I wonder if your idea has been tried; sounds interesting.


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