Psycho-Babble Medication Thread 192

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Re: Reboxetine (Edronax)

Posted by Nick on March 7, 1999, at 16:35:08

In reply to Re: Reboxetine (Edronax) , posted by Toby on October 14, 1998, at 10:21:35

> I've been prescribing reboxetine for a few months in the UK. It seems to work; insomnia is the main side effect reported to me; have also seen erectile failure (usually at >8mg/day) and urinary hesitancy in men (case report in the BJPsych about this: doxazosin effective treatment) Wt gain not a problem clinically or in trials published so far. Not licensed for use in elderly.

 

Re: Reboxetine (Edronax)

Posted by Teri on March 14, 1999, at 2:04:51

In reply to Re: Reboxetine (Edronax) , posted by Charyl on August 28, 1998, at 13:57:37

> > Message to Ian. My mother is 80 years old and
> severely depressed. She has been on every
> anti-depressant available in the U.S., and we were
> very excited about the prospect of Reboxetine,
> since one of the few drugs that had been able to
> help her in the past 35 years was imipramine, however, her doctor says she is now too old to take it. He is aware of Reboxetine and thinks it
> may help her, but is unwilling to try to prescribe
> it. We also tried to get her in a study in San
> Diego for Reboxetine, but again, she is too old.
> Do you have any idea how to get a doctor to prescribe Reboxetine, or how to get a package
> from England. We have been told that no doctor
> here would be willing to do this.
> > > I got more information about Endronax (Regboxetine) that may be of interest. I purchased a package through England to try (hoping to find one with out the sexual side effects). It came with a leaflet intended for patents only but included more information than I've seen to date.

> > > Listed side effects:
> > > Dry mouth, constipation, sweating, and insomnia

> > > ""Some men may have difficulty in having or maintaining an erection." (I found this to be all too true - could not even get started)

> > > Difficulty passing urine increased heart rate, feeling of pins and needles, orthopedic hypotension.

> > > Drug interactions:
> > > Drugs that lower blood pressure
> > > Other Ads
> > > Antibotics e.g. erythromycin, and fluvoxamine
> > > Azole antifungals e.g. fluconazole
> > > Heart drugs e.g. flecainide
> > > Cyclosporin
> > > Ergot derivatives

> > > From my subjective experience I found it to be quite similar to Bupropion but with a worse sexual side effect.

> > > I also tried reboxetine and had the same problem - I could not so much as begin to get an erection. I also found it very difficult to urinate, and a maximum dose of bethanecol was only partly helpful.
> > >
I've been on Wellbutrin, aderall, etc, both for depression and ADD, on and off (when they stop working) for years, I would really apreciate any information on how to get Reboxetin in the U.S., throught studies or prescribed.
Thank you

 

Re: Reboxetine (Edronax)

Posted by Dina on March 16, 1999, at 2:57:30

In reply to Re: Reboxetine (Edronax) , posted by Teri on March 14, 1999, at 2:04:51

I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)

Thanks,
-dina.
dgamboni@juno.com

 

Re: Reboxetine (Edronax) / bethanecol

Posted by dina on March 16, 1999, at 3:02:12

In reply to Re: Reboxetine (Edronax) / bethanecol , posted by steve on January 14, 1999, at 11:41:47

> someone mentioned bethanecol. What's this?

It's used to help with urinary retention and some sexual side effects.

It helped me a teeny tiny itsy bitsy bit with urinary retent. & inorgasmia (I think that's the proper term...) but you have to take it like all the time.

Although, I hear it works pretty well for some folks. Plus, the situation is different for men & women.

For sexual side effects, I've heard that some herbal remedies work quite well-- Yohimbe, especially. Also Ginko bilobo.

-dina.

 

Re: Reboxetine (Edronax) / bethanecol

Posted by Elizabeth on March 17, 1999, at 17:20:26

In reply to Re: Reboxetine (Edronax) / bethanecol , posted by dina on March 16, 1999, at 3:02:12

Bethanechol is a muscarinic cholinergic agonist - so it acts in opposition to certain drug effects, namely the *anti*cholinergic ones. The prototypical anticholinergic drugs are atropine and scopolamine, which can be found in deadly nightshade (Belladonna).

The major anticholinergic symptoms are dry mouth, constipation, blurred vision, urinary retention, cognitive impairment, and rapid heartbeat.

Antipsychotics, tricyclic antidepressants, some antihistamines (Benadryl, Atarax), and some of the drugs used to treat Parkinsonism (Cogentin, Artane) are some classes of drugs that have prominent anticholinergic effects.

-elizabeth

 

Re: Reboxetine (Edronax)

Posted by ZZbottom on March 29, 1999, at 17:17:39

In reply to Re: Reboxetine (Edronax) , posted by Nick on March 7, 1999, at 16:35:08

How can I get Reboxetine in U.S.?

 

Re: Reboxetine (Edronax)

Posted by Jeff on April 15, 1999, at 3:15:04

In reply to Re: Reboxetine (Edronax) , posted by Dina on March 16, 1999, at 2:57:30

> I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
>
> Thanks,
> -dina.
> dgamboni@juno.com

I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
even with increases in dosage. (This is my normal
pattern with medications and may not apply to others.)

 

Re: Reboxetine (Edronax)

Posted by Reg on April 15, 1999, at 7:50:22

In reply to Re: Reboxetine (Edronax) , posted by Dina on March 16, 1999, at 2:57:30

> I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
>
> Thanks,
> -dina.
> dgamboni@juno.com

I took Reboxetine for one day and felt severe anxiety, numbness (couldn't feel my legs), disorientation and slurring of speech. Heartbeat increased and I will never take this again

 

Re: Reboxetine (Edronax)

Posted by CC on April 20, 1999, at 8:46:32

In reply to Re: Reboxetine (Edronax) , posted by Jeff on April 15, 1999, at 3:15:04

> > I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
> >
> > Thanks,
> > -dina.
> > dgamboni@juno.com
>
> I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
> very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
> effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
> feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
> immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
> even with increases in dosage. (This is my normal
> pattern with medications and may not apply to others.)
>

Has anyone heard of reboxetine used in combination with
other medicines, specifically Zoloft and nortriptyline?

Are there dosage guidelines for such combinations?

 

Re: Reboxetine/refractory BD-1 depression

Posted by Nancy on April 21, 1999, at 9:58:00

In reply to Re: Reboxetine (Edronax) , posted by Jeff on April 15, 1999, at 3:15:04

> > I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
> >
> > Thanks,
> > -dina.
> > dgamboni@juno.com
>
> I was eager to try Reboxetine and ordered it online from a Swiss pharmacy in Zurich, Victoria Apotheke (www.access.ch/victoria_pharmacy) I am a
> very treatment-resistant BP2. I found the Reboxetine showed signs of working within 24-hours - but I am a quick responder. But it had positive
> effect after several days. I don't recall any major side-effects. I felt activated and motivated and had much more energy. I still had negative
> feelings and thoughts, so we added Prozac in conjunction after two weeks. The Prozac caused an
> immediate reversal of all the postive effects - within 24 hours. Prozac was stopped and - within 12 hours - the postive effects of the Reboxetine returned. After 5 weeks, the effects of the Reboxetine 'faded" away and could not be restarted
> even with increases in dosage. (This is my normal
> pattern with medications and may not apply to others.)
>

I'm severe bipolar-1, ultra-rapid cycling, anguished mixed states, treatment resistive, and chronically suicidal. No medication would work with my physiology until a brilliant pdoc insisted that my T3 and T4 thyroid levels MUST BOTH BE IN THE UPPER QUARTILE OF THE NORMAL RANGE. Once this was achieved, medication did what it was supposed to do. I was fortunate that the first AD (300mg Effexor XR) worked. Before upper quartile thyroid augmentation, I was treatment resistive in every trial on every US available AD (including 300mg Effexor XR).

I'm wondering if others with similar experience will compare their preferences for either Edronax or Effexor.

 

Re: Reboxetine (Edronax)

Posted by Bren on April 25, 1999, at 18:23:04

In reply to Re: Reboxetine (Edronax) , posted by ZZbottom on March 29, 1999, at 17:17:39

I've been on Edronax for 9 months.Vision is affected e.g. dry eyes and double vision.Since starting the maximum dose - noticed hair loss.

 

Re: Reboxetine (Edronax)

Posted by Eric on May 4, 1999, at 18:09:35

In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03

> I have been taking Reboxetine for 1 month for
chronic fatigue syndrome. I have suffered from CFS
for over 5 yrs after a sudden onset. I have tried
numerous SSRIs & MOI with little positive effect but
Reboxetine has given me a substantial energy boost.

Anyone out there have knowledge of Reboxetine/CFS?

 

Re: Reboxetine (Edronax)

Posted by GARY on May 6, 1999, at 19:38:30

In reply to Re: Reboxetine (Edronax) , posted by Eric on May 4, 1999, at 18:09:35

WHERE IS EDRONAX AVAILABLE? WHO MAKES IT?

 

Re: Reboxetine (Edronax)

Posted by Nick on May 9, 1999, at 12:48:47

In reply to Re: Reboxetine (Edronax) , posted by GARY on May 6, 1999, at 19:38:30

> WHERE IS EDRONAX AVAILABLE? WHO MAKES IT?

Its certainly available in the UK - its made by Pharmacia & Upjohn

Nick

 

Re: Reboxetine (Edronax)

Posted by Juan on May 9, 1999, at 17:18:08

In reply to Re: Reboxetine (Edronax) , posted by Nick on May 9, 1999, at 12:48:47

> When will Edronax be available in the U.S.A and is it helpfull for obsessional thinking as well as depression?

 

Re: Reboxetine (Edronax)

Posted by Betsy on May 9, 1999, at 22:30:18

In reply to Re: Reboxetine (Edronax) , posted by GARY on May 6, 1999, at 19:38:30

> WHERE IS EDRONAX AVAILABLE? WHO MAKES IT?

Edronax is available throughout most of Europe, but
is still in trials by the FDA here in the US.

I know someone in Austria who was taking it, but had
to stop due to excessive sweating - a common side-effect.

 

Re: Reboxetine source

Posted by George O on May 10, 1999, at 3:32:01

In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03

> For treating dysthmic disorder Effexor has worked much better than other SSRI have. Works well except for the sexual side effects. I am planning to try Reboxetine (Edronax) any information on this norepinephrine re-uptake inhibitor would be appreciated. I am hoping to get a good response minus the side effect.


I obtaine reboxetine from IAS, email ias@antiaging-systems.com, they also have the best price on SAMe. George

 

Re: Reboxetine (Edronax)

Posted by Ruy Sant'Anna on May 11, 1999, at 11:34:59

In reply to Re: Reboxetine (Edronax) , posted by Bren on April 25, 1999, at 18:23:04

> I've been on Edronax for 9 months.Vision is affected e.g. dry eyes and double vision.Since starting the maximum dose - noticed hair loss.

Is Edronax available in USA? Where can it be found? When Edronax will be available in Brazil?

 

Re: Reboxetine (Edronax)

Posted by Ruy Sant'nna on May 11, 1999, at 11:41:22

In reply to Re: Reboxetine (Edronax) , posted by Ruy Sant'Anna on May 11, 1999, at 11:34:59

> > I've been on Edronax for 9 months.Vision is affected e.g. dry eyes and double vision.Since starting the maximum dose - noticed hair loss.
>
> Is Edronax available in USA? Where can it be found? When Edronax will be available in Brazil?
Sorry I was mistaken, I believed I was asking my
question and not answering yours.Apologyzes.

 

Re: Reboxetine (Edronax)

Posted by Emma on May 15, 1999, at 17:22:09

In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03

Anyone heard when reboxetine is going to be relased in the US?

 

Re: Reboxetine (Edronax)

Posted by Jorge Gonzalez on May 15, 1999, at 20:55:36

In reply to Re: Reboxetine (Edronax) , posted by paulk on August 7, 1998, at 12:03:25

I need information about reboxetine in my country (Argentina). IŽd been taken efexxor for a long time but the result was partial.

Thanks

 

Re: Reboxetine (Edronax)

Posted by mary on May 16, 1999, at 18:05:29

In reply to Re: Reboxetine (Edronax) , posted by Emma on May 15, 1999, at 17:22:09

My psy doc said that he would be attending some meetings this week and would be asking for info re a release date. His feeling is that the advertising doesn't seem to be following the usual routine and his guess that it may be a while before the ddrug is on the market in the US. But as he says, "You never know."
Mary
> Anyone heard when reboxetine is going to be relased in the US?

 

Re: Reboxetine (Edronax)

Posted by Elizabeth on May 18, 1999, at 3:04:34

In reply to Re: Reboxetine (Edronax) , posted by mary on May 16, 1999, at 18:05:29

> My psy doc said that he would be attending some meetings this week and would be asking for info re a release date.

I imagine that he was referring to the APA meeting which is going on as we speak in DC. (Well, maybe not right now, as it's 4am eastern time!)

>His feeling is that the advertising doesn't seem to be following the usual routine and his guess that it may be a while before the ddrug is on the market in the US. But as he says, "You never know."

Yeah, that's the impression I get. But I wonder what's delaying it.

 

Re: Reboxetine (Edronax)

Posted by Jane on May 20, 1999, at 18:56:16

In reply to Re: Reboxetine (Edronax) , posted by Jeff on April 15, 1999, at 3:15:04

. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
> >
> > Thanks,
> > -dina.
> > dgamboni@juno.com
>
I'd like to know if anyone has any info on reboxetine and migraine. I have tried many of the SSRI's and they increase and cause migraines (for me). I noticed that one of the side effects listed for reboxetine was headache but am wondering if any one with migraine has tried it?!

 

Re: Reboxetine (Edronax)

Posted by Anne-Marie on May 22, 1999, at 14:55:46

In reply to Re: Reboxetine (Edronax) , posted by CC on April 20, 1999, at 8:46:32

> Has anyone heard of reboxetine used in combination with
> other medicines, specifically Zoloft and nortriptyline?
>
> Are there dosage guidelines for such combinations?

Hello,

Excuse me for my bad English, but I'm from Belgium.

About Edronax (reboxetine), my friend takes a combination of 2 MAOI's (Iprocloside and Nardalzine) in combination with Edronax. She responds very well to this combination therapy.
She's had major depression for several years now, and this is the first time she could be helped. She feels much better now and only has few side effects.


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