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Re: Do not do it!

Posted by MoonageDaydream on December 15, 2009, at 23:51:35

In reply to Re: Do not do it! MoonageDaydream, posted by babak on December 15, 2009, at 20:53:22

> I would like to suggest that your lack of energy, anhedonia, apathy and/or lethargy could have something to do with your metabolism either already compromised or compromised through long term use of Subutex.
> It could also have something to do with your liver functions.

Babak, aside from a couple of papers/case reports reporting hepatic issues with buprenorphine, I can't find much info on this. I thought that buprenorphine was generally safe and the few reports likely involved prior liver damage (from Hepatitis C or damage from acetaminophen) or from improper use of the drug (particularly, intravenous use). Am I incorrect in my assumptions? Any links about this would be appreciated.

Why do you think Subutex affected your liver function?

For what it's worth, I had my liver function checked 6 months ago, with the results being normal. Regarding metabolism, I will note that buprenorphine inhibits CYP3A4, as does Prozac and a number of other antidepressants. When I took Prozac, a 10 mg dose seemed much more potent than pre-Suboxone. Anyone taking Suboxone/Subutex with other medications should ask their doctor if a dosage alteration is necessary.




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