Posted by Babak on September 23, 2011, at 13:02:23
In reply to Re: Do SSRI's cause dopamine depletion, posted by metafunj on September 12, 2009, at 11:23:47
> Just thought I'd throw this in here. I posted it in the tread about dopamine depletion on SSRIs being a myth. I hope this helps to answer the initial question.
> Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]β-CIT and single photon emission computed tomography in subjects with obsessivecompulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
> Keywords: Serotonin and dopamine transporters; Single photon emission computed tomography; β-CIT; Serotonin reuptake inhibitor; Obsessivecompulsive disorder
I think different SSRIs have different effects on dopamine availablity. Citolopram is very different to Paxil.