Posted by nocturnal1 on May 10, 2011, at 21:00:32
In reply to GABA does reduce anxiety and promotes sleep!, posted by nocturnal1 on July 27, 2010, at 9:28:10
> There has been only negative scientific reviews on GABA supplements really working to block neurotransmitters that I could find (internet, I'm sure there are better sources!). I have tried it a couple of times and it is the only supplement on the OTC market that I find really works for anxiety and sleep, however, a tolerance developes quickly with it. I find it has to be taken on an empty stomach (45 min after last foods)with no other supplements. I first took a 750mg tablet and it worked as well as Klonopin, but without the addiction component. I tried it again at 750mg the next night and it didn't seem to do much. The research says that GABA does not really cross the blood-brain barrier. Now, it is been published on the net(ok, not the best source!) that GABA has to be taken in amounts of 2-6mg a night! So I tried it a week later at 1500mg and it worked! I felt good the next day too, no Rx med hangovers! Though, I suspect a tolerance is happening, and it happens with me and all supplements and prescription meds. I suspect I would have to keep upping the dose if I take it nightly(but, I have never stayed on anything long term for sleep or anxiety-mostly cause nothing works on me after awhile!). I probably won't take it every night, either. Physically, I feel a difference with GABA-very relaxed, it is doing something in my body, whether its crossing the blood brain barrier or not! After trying it repeatedly night after night, I believe my body has built up a tolerance to it.