Psycho-Babble Neurotransmitters | advanced medication issues | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Prestiq vs Cymbalta Conundrum

Posted by mtdewcmu on April 19, 2011, at 15:46:36

In reply to Re: Prestiq vs Cymbalta Jean brady, posted by Conundrum on March 21, 2011, at 13:59:31

> I found pristiq to be slightly better than Pristiq, although not a miracle drug.

There have been no miracle drugs in psychiatry since thorazine and lithium in the 1950s.

> I'm on Cymbalta now and it doesn't seem to do anything, except messing w/ my bowels and causing male problems. Pristiq actually helped in that area.

I grew to hate Paxil due to the bowel issues. Needless to say, I chose a different drug.

It seems like the jury is still out on the merits of hitting norepinephrine as a treatment for depression. None of the specific NE reuptake inhibitors have even come close in efficacy to SSRIs and older drugs. So, until someone can persuade me otherwise, I will believe that SNRIs are just SSRIs with more side effects.

You might think Effexor is a counterexample, in that it affects both 5-ht and NE and is as good of an AD as anything else. But venlafaxine itself operates mostly on 5-ht. Only the active metabolite has significant effects on NE. So, my gut feeling is that Effexor's effectiveness stems almost entirely from its SSRI-like properties.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Neurotransmitters | Framed

poster:mtdewcmu thread:980216