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Re: Please explain agomelatine action on 5HT? desolationrower

Posted by Franz on March 25, 2011, at 13:37:42

In reply to Re: Please explain agomelatine action on 5HT?, posted by desolationrower on March 25, 2011, at 6:29:46

> > Hello, Doc suggested switching from escitalopram 10 mg to agomelatine.
> >
> > It is very expensive so I have to evaluate it.
>
> agomelatine seems to be bit faster working than some other drugs. the best way to know is spend a week or three with it.


I took it for 11 days.
>
> > As I understand it enhances melatonin "reception" or sensitivity. When I used melatonin to sleep I had nightmares. Will this happen with agomelatine?
>
> maybe, maybe not. the 5ht2c antagonism should decrease time spent in REM so there should be less 'dreaming' than with pure melatonin.

Unfortunately not. I experience shortened sleep (4, 2, 5 hours) and frequent nightmares.

The good part is that it is easier to fall asleep.

>
> > The supposed (I read articles negating this) 5-HT2C receptor antagonism affects serotonin?. How does this compare to escitalopram. Can this also have an anti obsessive effect?
>
> serotonin=5ht. ssris are blunt, whereas blocking a certain receptor is a more specific effect. this can be good or bad; it can avoid side effects, or not do the useful thing you need. I think there is some evidence on 5ht2c in OCD though most looks at 5ht2a.
>

It seems that escitalopram is better for ruminarions.

Thanks.

 

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Psycho-Babble Neurotransmitters | Framed

poster:Franz thread:980083
URL: http://www.dr-bob.org/babble/neuro/20100607/msgs/981110.html