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Re: Please explain agomelatine action on 5HT? desolationrower

Posted by Franz on March 25, 2011, at 13:37:42

In reply to Re: Please explain agomelatine action on 5HT?, posted by desolationrower on March 25, 2011, at 6:29:46

> > Hello, Doc suggested switching from escitalopram 10 mg to agomelatine.
> >
> > It is very expensive so I have to evaluate it.
> agomelatine seems to be bit faster working than some other drugs. the best way to know is spend a week or three with it.

I took it for 11 days.
> > As I understand it enhances melatonin "reception" or sensitivity. When I used melatonin to sleep I had nightmares. Will this happen with agomelatine?
> maybe, maybe not. the 5ht2c antagonism should decrease time spent in REM so there should be less 'dreaming' than with pure melatonin.

Unfortunately not. I experience shortened sleep (4, 2, 5 hours) and frequent nightmares.

The good part is that it is easier to fall asleep.

> > The supposed (I read articles negating this) 5-HT2C receptor antagonism affects serotonin?. How does this compare to escitalopram. Can this also have an anti obsessive effect?
> serotonin=5ht. ssris are blunt, whereas blocking a certain receptor is a more specific effect. this can be good or bad; it can avoid side effects, or not do the useful thing you need. I think there is some evidence on 5ht2c in OCD though most looks at 5ht2a.

It seems that escitalopram is better for ruminarions.





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