Posted by linkadge on August 29, 2010, at 21:01:59 [reposted on August 30, 2010, at 0:49:14 | original URL]
Agents which act as both trk-b agonistand sigma-1r agonists would exhibit potent neurotrophic activity.
Fluvoxamine is a sigma agonist but not a trk-b agonist. Amitriptyline is a potent trk-b agonist but has lesser effect on sigma receptors.
what about combining fluvoxamine and amitriptyline? This would theoretically be potently neurotrophic.