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Re: Why would desipramine's effect on sleep change? » mtdewcmu

Posted by TriedEveryDrug on January 11, 2010, at 17:00:01

In reply to Re: Why would desipramine's effect on sleep change?, posted by mtdewcmu on December 18, 2009, at 4:55:03

> Another possibility is that perhaps tolerance occurs to the various effects of desipramine at different rates. Maybe you have developed a tolerance to the anti-histamine effect of desipramine, but not the pro-norepinphrine or pro-serotonin effect.


Do you think such a tolerance would last for months or years?

Browsing wikipedia just now I see desipramine's Kd is higher (less affinity) for Histamine1 than most of the other TCAs. interesting...

Thanks.

 

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poster:TriedEveryDrug thread:927870
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/933273.html