Posted by SLS on January 13, 2008, at 14:53:43 [reposted on January 15, 2008, at 3:12:46 | original URL]
In reply to Re: placebo response » SLS, posted by Larry Hoover on January 13, 2008, at 11:19:28
Good Day, Mr. Hoover.
> I'm trying to recall, but I do believe this is the only study I've come across where the placebo group came out on top. However, I have to agree with Scott, that this can only be viewed as a failed study. The inclusion of an active comparator that also failed implicates the methodology, rather than the investigative drug. It's useful for generating new hypotheses, but worthless insofar as answering any.
I'm not sure my recollection is accurate, but I think a duloxetine study was failed after it resulted in fluoxetine, the active comparator, being less effective than placebo. This indicated to the FDA that more tests were obligatory before it would deem duloxetine "approvable".
You are so cool.
I'm glad you happen to be posting on the board while I'm here. I can't tell you what an INCREDIBLY valuable person you are. Of course, the same can be said of every living soul. I do consider you to be one of my personal favorites, though.