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Re: Increase MAO-A to reduce Neurontransmitters?

Posted by farshad on December 3, 2017, at 14:54:31

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by linkadge on December 3, 2017, at 13:07:45

> Oh I'm sorry. I am not a diagnostician, but you seem to want one who doesn't ask questions?
> The MAO variants that are reported by common genetic tests are only weakly associated with functional brain MAO levels.
> Also, in many cases, higher MAO levels are associated with depression and social stress induced anhedonia (remarkably reversed by MAO inhibitors).
> Mood stabilizers (lithium, valproate) and other GSK3 inhibitors may increase monoamine oxidase levels, over time, through downstream interactions with per2.
> However, genetic tests are only in their infancy. The actual functional level of brain serotonin depends on the activity of likely hundreds of receptors, enzymes, neurotransmitters etc. Tryptophan hydroxylase, SERT, 5-ht1a, 5-ht1b, GSK3, just to scratch the surface.
> Also, increasing MAO-A may leave you with lower levels of norepinephrine and dopamine (in addition to serotonin) as this enzyme catabolizes all three.
> Linkadge

yeah I know it increasing MAO will decrease dopamine also.
Progesterone increases both MAO a and B from what I have read.
Progesterone also increases COMT which I think also reduces neurontransmitters? not sure. Anyway ... I just want this to work. I just wanna reduce my serotonin levels. Progesterone also increases GABA which decreases neuron firing so less active serotonin.Well im like on day 3 now on progesterone cream applying it on my skin.. I do feel the effect somewhat. Do you know if it takes time when you introduce something that increases MAO for the neurontransmitters to start depleting hard?




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