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Re: Niacinamide for SA + Depression Christ_empowered

Posted by Escapee on September 6, 2016, at 18:57:02

In reply to Re: Niacinamide for SA + Depression, posted by Christ_empowered on September 6, 2016, at 17:26:35

> I think niacinamide potentiates BZD tranquilizers and some anticonvulsants because of its actions at GABA receptors. Niacinamide can help ease people off of BZD drugs during tapers.
> Vitamin C is an awesome nutrient. I take 2 doses of 10 grams each, time release tablet form. I think the large Vitamin C doses also help reduce anxiety and agitation for me. From what I understand...high dose vitamin C works on dopamine receptors and can make AP/AAP drugs work better (important for me), while niacinamide works at GABA receptors and does something beneficial with serotonin, tryptophan, melatonin levels, etc. Sooo...for me, the high dose C potentiates the neuroleptic (for me, Abilify) while the B3 is acting sort of like a BZD would (but w/o adverse effects), plus it probably potentiates my lamictal and/or Trileptal.
> The problem with vitamin C, especially instant release, is keeping a steady flow going and getting adjusted to higher doses. I imagine the orthomolecular people have info online about how to ramp up your dosage gradually and avoid adverse effects (mostly gastrointestinal). I use 2 doses of time release to get a more or less steady stream of C going with 2 doses, instead of 4+ with instant release or powders.
> Personally...I'd start the C and B3 together. The Hoffer stuff I read said that the combo reduces the risk of liver enzyme elevation, jaundice, etc., plus its...good for you, it seems. I'd recommend you throw in a b-50 or b-100, too, but that's me. The Orthomolecular people think that if you high dose your B3, you should probably supplement your other B complex vitamins, as well.
> Since I"m on a neuroleptic, I also take high dose natural form E with mixed tocopherols (1,000 IU per day, with a high fat meal). This is important for those of us on the AP/AAP drugs to reduce the risk of TD. Anybody can benefit from E, though, so maybe consider adding that, too (?).
> I don't take the B3 as needed. When I do take more than I usually do, I experience a calming effect. My wild *ss guess is that the extra B3 works because I've been on the baseline dosage B3 for so long. I don't think it would work if I only took the B3 PRN.

Hi and thanks again!

I do actually take a fair few supplements. Vit E 800iu, vit D 2500iu, 2 different multis (one is aimed at hair and skin) and together my B vits are optimal and especially the minerals which are all highly absorbable forms (amino chelated, citrates, gluconates etc). Plus extra chromium (600mcg total), zinc (45mg total), B1 (135mg total), biotin (1.3mg total) & 300mg magnesium citrate & also a B formula containing 17mg B6 as P-5-P (important when taking Nardil), 1mg B12 as methylcobalamine & 400mcg Folate as L-5-methyltetrahydrofolate. The enzyme activated forms.

What I plan on doing with the vit C is continue my 3g of timed release whilst adding the higher powder doses on top. Might keep the blood levels bit more even than powder alone.

And if it seems like I take too many different supplements, well you simply cannot fit all the nutrients you need or want into a few pills.

I take other supplements too like EAAs, Saw Palmetto, omega 3 & 6 EFAs and other things. Thankfully I have a large calendar pill organizer which can hold the majority of the supps & meds for a week. And I have a few herbs on stand-by, ready for battle against Nardil induced urine retention and impotence!

Finally 2 protein shakes each day as recently I've lost my appetite big-time!

Oh, I also have type 1 diabetes which is why I take high doses of certain supps like B1 and chromium. Hmm, isn't B3 part of GTF?

Funny how sometimes you get a 'speedy' effect from ADs before the mood lift kicks in. Touch wood.


Amitriptyline 100mg
Bupropion 150mg
Quetiapine 150mg
Clonazepam 2mg
Pregabalin 400mg
Phenelzine (Nardil) 45mg




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