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probiotics, lactobacillus rhamnosus, anxiety, etc.

Posted by qqqsimmons on October 14, 2011, at 9:33:30

i've been trying rhamnosus for a few weeks. it seems to work very well for my social anxiety.

i've actually began considering deliberating on making some life changes based on the lower anxiety and resulting confidence...(also, feeling very frustrated with the situation my shyness etc., has created in my life)...

i started with country life power-dophilus once daily plus a cup of yogurt with active rhamnosus cultures (i think only the "organic" brands had this culture at my local supermarket)...i also picked up some nature's way primadophilus, for when i'm too constipated for yogurt...all pills kept in fridge at store and home...

i would be curious if anyone can duplicate these results. i guess i'll find out before too long how much is placebo or if there's any unexpected side effects.

i felt a bit hypomanic yesterday and had sleep issues, not sure if this is going to be a detrimental side effect like natural mao-inhibitors and insomnia...


Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve


There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In addition, L. rhamnosus (JB-1) reduced GABAAα2 mRNA expression in the prefrontal cortex and amygdala, but increased GABAAα2 in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gutbrain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.




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