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Glycine and the NMDA receptor

Posted by Netch on August 29, 2007, at 8:46:58

Glycine is known to be a major inhibitory neurotransmitter in the brainstem and spinal cord
but it's also known to function as a coagonist at the NMDA receptor.
Studies have shown that glycine alleviate negative symptoms in schizophrenia, possibly through NMDA receptor stimulation.
On the other hand NMDA receptor antagonists have antidepressant-like activity.

Does this make sense?


 

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