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Re: Lar, Undermethylators and Folate » Ron Hill

Posted by MoparFan91 on August 8, 2007, at 8:54:42

In reply to Lar, Undermethylators and Folate, posted by Ron Hill on July 30, 2007, at 20:00:49

Yes, Folic Acid is said to increase depression in histadelics (undermethylators). Reason for this is that it increases histamine levels (reason it's recommended for histapenics), and this, inturn, can block serotonin production. The reason for the high Folate levels in histadelics is a problem in converting it to the active Folinic Acid form, which is required for methylation. I've read that the active Folinic Acid form is fine for undermethylators as it's commonly given to autistics with this condition.

I fit virtually all the symptoms of pyrrole disorder (ultra rapid-cycling bipolar being a hallmark of it), and for histadelia (undermethylation), I fit the second most for that (OCD being a hallmark of it).

I've always thought that the pyrrole disorder was the only one I have, which I was hoping, but I believe I certainly have histadelia (undermethylation) as well in part due to bad reactions I've had to Folic Acid. Additionally, I found that I've had negative reactions to Niacin, protein w/ high amounts of histidine, and also acetylcholine-boosting supplements.

A couple nights ago, I ate 3 eggs as part of my dinner. Eggs (mainly the yolk part) are one of the highest food sources of Folic Acid. Well, not long after that, my felt my mood sink into immense depression, and I started to feel agitated along with it. Before all of this, my mood had been pretty much even. I took Magnesium Glycinate and Taurine, and it the depression went away within about 2 hours.

I took Niacin months back, and I was also pitched into severe depression. I think it cause blood sugar problems, too. I've read of Niacin increasing histamine levels, and therefore, being a methyl-eater. It's one of the main supplements along with Folic Acid recommended for histapenia (overmethylation). Niacinamide caused a big rash.

On the other hand, I get benefits from SAM-e. I seem to be able to sleep more easily on it, and it's easier to let go of OCD stuff. It's quickly given me relief when in severe depressions as well. I use 800mg (400mg Elemental), but 400mg (200mg Elemental) seems to still give results as well. So, I use the lower amount as maintenance.
I started taking it again because I know for sure that I need it since I don't have just the pyrrole disorder alone.


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