Posted by MM on April 29, 2007, at 3:50:18
In reply to Re: Myelination? » MM, posted by Larry Hoover on April 21, 2007, at 11:31:19
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> I hadn't come across this hypothesis before. Thanks for bringing it up. Rather a recent angle for studying mood disorders, from what I can surmise.
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> Other posters have already given you good advice, in omega-3, B12, vitamin D. You're also correct that lecithin couldn't hurt, being a source of phospholipids. Interesting enough, though, is a recent finding of the direct stimulatory effect of the omega-6 fatty acid, gamma-linolenic acid (GLA, found abundantly in borage, evening primrose and black currant oils), on maturation of oligodendrocytes and thus myelin sheet formation.
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> Lar
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> Reference:
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> Dev Neurosci. 2006;28(3):196-208.
> Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells.
> van Meeteren ME, Baron W, Beermann C, Dijkstra CD, van Tol EA.
> Biomedical Research Department, Numico Research B.V., Wageningen, The Netherlands.
>
> Dietary polyunsaturated fatty acids (PUFAs) have been postulated as alternative supportive treatment for multiple sclerosis, since they may promote myelin repair. We set out to study the effect of supplementation with n-3 and n-6 PUFAs on OLN-93 oligodendroglia and rat primary oligodendrocyte differentiation in vitro. It appeared that OLN-93 cells actively incorporate and metabolise the supplemented PUFAs in their cell membrane. The effect of PUFAs on OLN-93 differentiation was further assessed by morphological and Western blot evaluation of markers of oligodendroglia differentiation: 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), zonula occludens-1 (ZO-1) and myelin-associated glycoprotein (MAG). Supplementation of the OLN-93 cells with n-3 and n-6 PUFAs increased the degree of differentiation determined by morphological analysis. Moreover, CNP protein expression was significantly increased by gamma-linolenic acid (GLA, 18:3n-6) supplementation. In accordance with the OLN-93 results, studies with rat primary oligodendrocytes, a more advanced model of cell differentiation, showed GLA supplementation to promote oligodendrocyte differentiation. Following GLA supplementation, increased numbers of proteolipid protein (PLP)-positive oligodendrocytes and increased myelin sheet formation was observed during differentiation of primary oligodendrocytes. Moreover, increased CNP, and enhanced PLP and myelin basic protein expression were found after GLA administration. These studies provide support for the dietary supplementation of specific PUFAs to support oligodendrocyte differentiation and function.
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>Hmm, I've been taking EPO for a while, off and on...I can't say I've noticed a mood "stabilizing" effect really but I don't feel like it's making me worse so I'll keep taking it and hope I guess. Still having trouble with the fish oil. Thanks for the reply/help!
poster:MM
thread:749968
URL: http://www.dr-bob.org/babble/alter/20070410/msgs/754349.html