Posted by Larry Hoover on April 21, 2007, at 11:59:44
In reply to Pregenalone, posted by Tom Twilight on April 19, 2007, at 11:42:27
> Pregenalone really calms me down
>
> Its bizare since DHEA makes me anxious, I thought they were more or less the same thing?With respect to neuroactive steroids, it is the difference between the substances that makes all the difference. It is a mistake to assume that because they are hard to tell apart by chemical structure, that they also have similar function. As far as their effects go, they are very different.
One immediate effect of pregnenolone is to stimulate the same dopaminergic reward pathway as does morphine. However, a chronic effect is to downregulate GABA-A receptor sensitivity. I would assume there are numerous other effects, both primary and secondary, because that is a basic property of a hormone, to have huge effects at tiny doses. I think you're playing with fire.
Lar
poster:Larry Hoover
thread:751328
URL: http://www.dr-bob.org/babble/alter/20070410/msgs/751984.html