Posted by Tomatheus on January 14, 2007, at 23:31:04
In reply to How to increase monoamine oxidase (?), posted by linkadge on January 12, 2007, at 20:24:45
> I asked before but don't remember the answer.
>
> Does anyone know any supplements that might increase MAO activity?Hi Linkadge,
I responded to your original post on increasing MAO activity with some thoughts on copper supplementation. Here's a link to my response:
http://www.dr-bob.org/babble/alter/20061013/msgs/702120.html
Another type of supplement that might increase MAO activity would be something with anti-estrogenic properties. Holschneider et al. (1998) found that estrogen administration significantly decreased MAO-A activity in the hypothalamus (-28%) and amygdala (-21%) of female rats. The researchers also detected significant reductions in MAO-B activity in the liver (-30%), kidney (-22%), and uterus (-57%) of the rats. Another group of researchers (Gundlah et al., 2002) found that estrogen treatment reduced the optical density of MAO-A mRNA in the dorsal raphe nucleus and in the hypothalamic paraventricular nucleus, lateral hypothalamus, and ventromedial nucleus of spayed rhesus monkeys.
So, if you're willing to try a supplement with anti-estrogenic properties, then that should theoretically raise MAO activity (assuming that the supplement doesn't also reduce MAO activity by some other mechanism). And that's assuming that such a supplement exists. I'm not sure if there are any commercially available supplements that reduce estrogen activity, but then again, I haven't looked.
Hope this helps a little.
Tomatheus
==
REFERENCES
Gundlah, C., Lu, N. Z., & Bethea, C. L. (2002). Ovarian steroid regulation of monoamine oxidase-A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology, 160, 271-282. Abstract: http://www.springerlink.com/content/xnynf4ywfnj1ywwb/
Holschneider, D. P., Kumazawa, T., Chen, K., & Shih, J. C. (1998). Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. Life Sciences, 63, 155-160. Abstract: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9698044&dopt=Citation
poster:Tomatheus
thread:721832
URL: http://www.dr-bob.org/babble/alter/20070114/msgs/722395.html