Posted by blueberry1 on December 24, 2006, at 18:12:49
This study is informal and 6 years old but sure looked interesting. I mean, of 11 patients who finished the study, 10 of them responded? When was the last time a pharmaceutical medication did that? Scores dropped on average from 27 to 9? That's not too shabby. Look at the doses though. 800mg to 3600mg? 3600mg? Wow. The highest I've heard of up until now is 1800mg. The patients had Parkinsons too, so maybe that is a clue that SAMe will work best in people who have some kind dopamine malfunction? Anyway, I started SAMe yesterday. Hope it goes ok.
1: Mov Disord. 2000 Nov;15(6):1225-9. Links
S-Adenosyl-Methionine improves depression in patients with Parkinson's disease in an open-label clinical trial.Di Rocco A, Rogers JD, Brown R, Werner P, Bottiglieri T.
Department of Neurology, Beth Israel Medical Center-Albert Einstein College of Medicine, New York, NY 10003, USA.We report a pilot study of S-adenosyl-methionine (SAM) in 13 depressed patients with Parkinson's disease. All patients had been previously treated with other antidepressant agents and had no significant benefit or had intolerable side effects. SAM was administered in doses of 800 to 3600 mg per day for a period of 10 weeks. Eleven patients completed the study, and 10 had at least a 50% improvement on the 17-point Hamilton Depression Scale (HDS). One patient did not improve. Two patients prematurely terminated participation in the study because of increased anxiety. One patient experienced mild nausea, and another two patients developed mild diarrhea, which resolved spontaneously. The mean HDS score before treatment was 27.09 +/- 6.04 (mean +/- standard deviation) and was 9.55 +/- 7.29 after SAM treatment (p < 0.0001). Although uncontrolled and preliminary, this study suggests that SAM is well tolerated and may be a safe and effective alternative to the antidepressant agents currently used in patients with Parkinson's disease.
PMID: 11104210 [PubMed - indexed for MEDLINE]
poster:blueberry1
thread:716212
URL: http://www.dr-bob.org/babble/alter/20061218/msgs/716212.html