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Re: any valerian/valium link?

Posted by nolvas on September 25, 2006, at 19:09:30

In reply to Re: any valerian/valium link?, posted by sregan on September 25, 2006, at 16:17:55

The mechanism of action with regard to Valerian is debateable >

"Mechanism of Action

Due to valerian's historical use as a sedative, anti-convulsant, migraine treament and pain reliever, most basic science research has been directed at the interaction of valerian constituents with the GABA neurotransmitter receptor system. These studies remain inconclusive and all require independent replication. The mechanism of action of valerian in general, as a mild sedative in particular, remains unknown. Valerian extracts appear to have some affinity for the GABAA (benzodiazepine) receptor, [1][2] but this activity does not appear to be mediated by valerenic acid, but rather by the relatively high content of GABA itself."


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