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Re: TO ED UK - IS 1600 IU safe each day? » Jeroen

Posted by Larry Hoover on October 25, 2005, at 12:09:11

In reply to TO ED UK - IS 1600 IU safe each day?, posted by Jeroen on October 25, 2005, at 9:40:29

> TO ED UK - IS 1600 IU safe each day of those mixed tocepherol the link i showed you?

Yes. Absolutely.

I can't think of any subject that has become more prone to scare tactics than is vitamin supplementation.

The Upper Limit for daily intake of alpha-tocopherol is set at 1410 IU (1000 mg/day).

How was that number determined? From studying rats. Rats were given 500 mg/kg/day throughout their lives. After about 24 weeks, subtle changes in blood clotting capacity emerged. Despite clear evidence that the changes were due to vitamin K deficiency, these changes were accepted as the Lowest Observeable Adverse Effects Level indicator symptoms for adverse effects of vitamin E intake.

But how do you determine safe human intakes from chronic massive intake effects in rats? You apply various safety factors (mathematical reduction), which convert the rat threshold of effect into a safe threshold for humans. Using those safety factors, 500 mg/kg/day in rats is prudently equated to 14 mg/kg/day in humans (36-fold reduction). Just to be on the safe side. And ignoring the fact that the adverse effects were not due to vitamin E at all, but were signs of vitamin K deficiency.

Jeroen, I see no reason for you to be worried about trying to treat your symptoms with vitamin E, at your suggested dose level. Yes, I would recommend using the mixed tocopherols, like you have found at that website. It would be prudent to ensure that you also get good intake of vitamin C and alpha-lipoic acid, as they work in tandem with vitamin E. Also, one meal a week of dark green leafy vegetables would ensure that you are not deficient in vitamin K.

Good luck. I wish you success.

Lar

 

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URL: http://www.dr-bob.org/babble/alter/20051025/msgs/571707.html