Posted by Larry Hoover on October 25, 2005, at 12:09:11
In reply to TO ED UK - IS 1600 IU safe each day?, posted by Jeroen on October 25, 2005, at 9:40:29
> TO ED UK - IS 1600 IU safe each day of those mixed tocepherol the link i showed you?
Yes. Absolutely.
I can't think of any subject that has become more prone to scare tactics than is vitamin supplementation.
The Upper Limit for daily intake of alpha-tocopherol is set at 1410 IU (1000 mg/day).
How was that number determined? From studying rats. Rats were given 500 mg/kg/day throughout their lives. After about 24 weeks, subtle changes in blood clotting capacity emerged. Despite clear evidence that the changes were due to vitamin K deficiency, these changes were accepted as the Lowest Observeable Adverse Effects Level indicator symptoms for adverse effects of vitamin E intake.
But how do you determine safe human intakes from chronic massive intake effects in rats? You apply various safety factors (mathematical reduction), which convert the rat threshold of effect into a safe threshold for humans. Using those safety factors, 500 mg/kg/day in rats is prudently equated to 14 mg/kg/day in humans (36-fold reduction). Just to be on the safe side. And ignoring the fact that the adverse effects were not due to vitamin E at all, but were signs of vitamin K deficiency.
Jeroen, I see no reason for you to be worried about trying to treat your symptoms with vitamin E, at your suggested dose level. Yes, I would recommend using the mixed tocopherols, like you have found at that website. It would be prudent to ensure that you also get good intake of vitamin C and alpha-lipoic acid, as they work in tandem with vitamin E. Also, one meal a week of dark green leafy vegetables would ensure that you are not deficient in vitamin K.
Good luck. I wish you success.
Lar
poster:Larry Hoover
thread:568348
URL: http://www.dr-bob.org/babble/alter/20051025/msgs/571707.html