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Re: PS, wellbutrin, cortisol » Jakeman

Posted by KaraS on June 7, 2005, at 15:09:51

In reply to Re: PS, wellbutrin, cortisol, posted by Jakeman on June 7, 2005, at 12:00:54

> Forgot to mention, I take Wellbutrin. Could PS have an augmenting or synergistic effect with Wellbutrin?
>
> This study mentions the cortisol blunting and mood improving effect:
>
> Nutr Neurosci. 2001;4(3):169-78. Related Articles, Links
>
> The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor.
>
> Benton D, Donohoe RT, Sillance B, Nabb S.
>
> Department of Psychology, University of Wales Swansea, United Kingdom. d.benton@swansea.ac.uk
>
> There have been previous reports that supplements of phosphatidylserine (PS) blunted the release of cortisol in response to exercise stress and that it improved mood. The present study extended these observations by considering whether PS supplementation influenced subjective feelings of stress and the change in heart rate when a stressful mental arithmetic task was performed. In young adults, with neuroticism scores above rather than below the median, the taking of 300mg PS each day for a month was associated with feeling less stressed and having a better mood. The study for the first time reports an improvement in mood following PS supplementation in a sub-group of young healthy adults.
>
> PMID: 11842886 [PubMed - indexed for MEDLINE]
>


I wouldn't be surprised if the PS works well with Wellbutrin. Dr. Priscilla Slagle lists these properties of PS on her web site:

-Improve the fluidity & permeability of brain & all cell membranes (critical to proper cell functioning).

-Stimulate neurotransmitter release.

-Increase brain glucose consumption & utilization.

It would make sense that these things would help an antidepressant to work better.

I have a feeling that I would get more of a response if I took 300 mg. a day for a few months but I can't afford to try that now. But it's definitely on my list just as soon as I win that lottery!

k



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