Posted by Larry Hoover on April 27, 2005, at 9:14:43
In reply to Re: NIACINAMIDE for Anxiety, SP/PD, posted by sdb on April 26, 2005, at 15:41:15
> Thats interesting. I have never heard it would inhibit mast cell "degranulation". I think that could be useful especially for me in the spring. But perhaps it could sensibilize (through IgE globulins) your immunsystem once you stop the niacinamide. If you take a not cardioselecive betablocker you should be cautious not to have inflammation and therefore spastic constriction of the bronchioli.
It's a direct, receptor-stabilizing inhibitory effect. Niacinamide "raises the threshold" for mast cell histamine release. All the relevant research was done in Eastern Europe, during the Cold War. They had a totally different philosophy over there. E.g., Picamilon is a result of the research into niacinamide modulating the GABA(A) receptor. Anyway, here are some suggestive titles of papers in the Pubmed archives....no abstracts (though I've found bits of the contents, in other places).
Chyrek-Borowska S, Gruszecka M, Hofman J.
[Combined treatment with hypostamine and nicotinamide of allergic reactions and asthma]
Pol Tyg Lek. 1978 Jan 16;33(3):107-8.
Bekier E, Maslinski C.
Antihistaminic action of nicotinamide.
Agents Actions. 1974 Aug;4(3):196.
Bekier E, Wyczolkowska J, Szyc H, Maslinski C.
The inhibitory effect of nicotinamide on asthma-like symptoms and eosinophilia in guinea pigs, anaphylactic mast cell degranulation in mice, and histamine release from rat isolated peritoneal mast cells by compound 48-80.
Int Arch Allergy Appl Immunol. 1974;47(5):737-48.
Bekier E, Czerwinska U.
The effect of nicotinamide on the experimental asthma in guinea pigs.
Acta Physiol Pol. 1973 Nov-Dec;24(6):887-9.
Bekier E, Szyc H, Czerwinska U, Maslinski C.
The influence of nicotinamide on the course of experimental bronchial asthma in guinea pig.
Agents Actions. 1973 Oct;3(3):176.
Czezowska Z, Kowal-Gierczak B, Wrzyszcz M.
The effect of nicotinamide on the urinary 17-hydroxysteroid excretion in patients with allergic bronchial asthma.
Pol Med J. 1971;10(1):42-6.
Wyczolkowska J, Maslinski C.
Inhibition by nicotinamide of an homologous PCA reaction and antigen-induced histamine release from rat peritoneal mast cells.
Int Arch Allergy Appl Immunol. 1975;49(3):285-92.