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Re: niacinamide for asthma? » Larry Hoover

Posted by green willow on March 3, 2005, at 22:45:02

In reply to Re: niacinamide for asthma? » green willow, posted by Larry Hoover on March 2, 2005, at 15:23:56

Thanks, Lar. Maybe you can help me with a few more questions: Does it matter what dosage I use? The only kind of niacinamide I could find was 500 mg. If I need a smaller dose, is it allright to open the capsule and take some it out, or does that change the way it is absorbed? Is it rough on the stomach taken that way? Should I continue to use my pulmicort? I am on MTX also, niacinamide won't interfere with it, will it? Thanks!
> > I am trying niacinamide to reduce my asthma and so far have not had positive results. I had actually read about it on this board. Can anyone direct me to any online medical information or other resources which might support that niacinamide can be helpful for asthma?
> > Thanks much, Green Willow
>
> Most of the primary research was done over thirty years ago, and much of it in the former Soviet Union. Abstracts or other references are very hard to come by.
>
> Niacinamide does two things. One, it directly inhibits mast cell degranulation, which would release histamine in response to exposure to an allergen. Secondly, it helps restore sensitivity to glucosteroids, and can thereby inhibit inhaled steroid dependency in chronic asthma.
>
> Probl Tuberk. 1996;(5):41-4.
>
> [Recovery of immunological responsiveness in patients with bronchial asthma during nicotinamide treatment]
>
> [Article in Russian]
>
> Kosogorova LS, Kovalenko NN, Liubenko VA, Novosad FI.
>
> Institute of Phthisiology and Pulmonology of FG Ianovskogo, Ukraine AMN, Kiev.
>
> It has been found that among patients with bronchial asthma (BA) there are individuals with primary complete or partial lymphocytic resistance to glucocorticoid hormones (GC), which is apparently to be associated with cellular immunodeficiency and lower counts of young cortisol-sensitive cells in these patients. This condition may be aggravated with GC use and may appear as steroid dependence with all its clinical manifestations. It has been demonstrated that cellular steroid dependence may be either decreased or completely eliminated by special therapy aimed at enhancing lymphocytic sensitivity to hormones. Nicotinamide served as the drug of choice, which promoted the recovery of GC lymphocytic sensitivity, which may be attributed to the positive effects of the drug on the systemic immunity of BA patients.
>
>
> Lar
>


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