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Re: More Niacinamide questions » Larry Hoover

Posted by KaraS on December 24, 2004, at 13:16:52

In reply to Re: More Niacinamide questions » KaraS, posted by Larry Hoover on December 24, 2004, at 9:28:21

> > Larry,
> >
> > I wasn't clear as to whether you were saying that niacinamide could be taken with an MAOI or not. I think you were inferring that it could be but I wanted to make absolutely sure in this case.
>
> I can't think of a single reason why there should be any problem combining them.

Great!

> > The niacinamide is still working really well for me. After the first couple of days where it would wear off in a few hours, now it seems to linger for quite a while. I found the dose that keeps me calm enough and yet allows me some cognitive functioning. It's between 1/3 - 1/4 of a 500 mg. capsule and I take it twice a day. It gives me continuous coverage without any rebound anxiety. It's really a huge help for the time being. The anxiety is at least 90% under control now and I can function at the temporary jobs.
>
> I'm so very glad. That is a Christmas gift, hearing the good news.


Thanks. That's very sweet of you to say.

>
> > Speaking of cognitive functioning, do you notice the anticholinergic effects of the trimipramine negatively impacting your cognitive functioning? I used to feel that the low dose doxepin, and to a lesser extent maprotiline, that I took for sleep, did make it harder to concentrate. I wonder why you decided on trimipramine rather than doxepin or maprotiline to help you sleep since I think that both of them are supposed to be less anticholinergic?
> >
> > K
>
> It's kind of a fluke, and kind of an experimental outcome.
>
> When I went to my family doctor seeking a histaminergic sleep augmentative med, I presented a list of the three most histaminergic tricyclics (doxepin, trimipramine, amitryptiline), and basically said, "Pick one, but don't pick amitryptiline." He confused doxepin for a different drug, so I ended up with trimipramine. This was added to Zoloft, at the time. It seemed to be losing efficacy, even at 50 mg, but I found the anticholinergic aspects too strong at 50 mg, so a dose increase was out of the question. At that point, my doc allowed a trial of doxepin (apparently, the confusion had disappeared by then). Despite its stronger histaminergic activity, it worked less well than did the trimipramine, so I switched back. At this point, I had withdrawn from Zoloft, and I'm back at 25 mg trimip.
>
> I didn't even consider maprotiline. What is its claim to fame? Doesn't it have a very long half-life?
>
> Lar

I didn't realize that it's half-life was that long but it didn't really adversely affect me. I thought that MAP was one of the most anithistaminic of the sedating TCAs and yet less anticholinergic. I used to take doxepin for years for sleep but then I switched to MAP. MAP was much better for me. I didn't feel as much of a groggy hangover in the morning. It may be too subtle for your sleep problems though.

K


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URL: http://www.dr-bob.org/babble/alter/20041212/msgs/433773.html