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osteoporosis and hormones

Posted by raybakes on November 29, 2004, at 6:30:58

Was looking up the effects of horny goat weed (epimedium) after I tried it and felt wonderful. Found it reduces an inflammatory chemical called interleukin 6 that is involved osteoporosis...think interleukin 6 also regulates tsh, acth and vasopressin.

Role of Interleukin-6 and Its Receptors in the Osteoporosis of Sex-Steroid Deficiency

The production of interleukin-6 by cells of the stromal-osteoblastic lineage is inhibited in vitro by estrogen and androgen [51,75] through receptor-mediated actions on the transcriptional activity of the interleukin-6 gene promoter [51,76-78]. Conversely, estrogen loss results in increased production of interleukin-6 by ex vivo bone marrow cell cultures, and increased production of interleukin-6 follows the withdrawal of estradiol from primary cultures of calvarial cells [79]. In agreement with in vitro evidence, circulating levels of interleukin-6 are elevated in estrogen-deficient mice, rats, and humans [74]. Direct support for the contention that interleukin-6 is responsible for increased bone resorption after loss of sex steroids is derived from studies showing that injections of an interleukin-6-neutralizing antibody in female or male mice that have had gonadectomy prevents the increase in osteoclastogenesis in bone marrow and the increase in the number of osteoclasts in sections of trabecular bone [51,80]. Furthermore, unlike wild-type controls, interleukin-6 knockout mice do not show cellular changes in the marrow and trabecular bone sections and are protected from the loss of trabecular bone after the loss of sex steroids [48,51].


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poster:raybakes thread:421735
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/421735.html