Posted by Larry Hoover on November 2, 2004, at 9:28:34
In reply to Re: dopamine oxidation » Larry Hoover, posted by raybakes on October 31, 2004, at 3:57:54
> > > Genetically i have high interleukin 1 and low glutathione (null gene), so I'm predisposed to autoimmune disease -
> >
> >How did you find out about the glutathione problem? And isn't IL-1 a response to oxidative stressors?
>
> That's OK Larry! The gene tests were from great smokies - I do have a couple of glutathione genes but have one that is a null gene.That redundancy is probably keeping you safe.
> Yes oxidative stress is a major factor in Il-1 release and as you say, PLA2 is a big problem - I do take max DHA by Jarrow, but some research says that pure EPA is a better inhibitor of PLA2.
Yes, but. The 2 in PLA2 is a positional specificity of the phospholipid hydrolysis. Whatever fatty acid is hanging there gets freed, and it is most likely to get cyclized. The eicosanoids arising from EPA do have that specific inhibitory effect, but as I understand it, the release of DHA from that position goes on to modulate gene expression. EPA has an acute suppressive effect, whereas DHA has a chronic down-regulatory effect.
http://www.pubmedcentral.gov/articlerender.fcgi?artid=122397Look at Table 5.
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=208755
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=139963
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=149905
> I'm interested in the caspases, that are releasing enzymes for the interleukins, and how mitochondrial damage can set neuronal apoptosis into action - interestingly, glutathione and creatine, inhibit caspases.
>
> Got to go to work now, so will reply more in full later - thanks for your concern!! hope you didn't lose too much sleep!!!
>
> RayBrain hum, Ray. I get involved....no, INVOLVED.
Lar
poster:Larry Hoover
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/410545.html