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Re: L-glutamine ..forgot to add,,,JLx..mmb

Posted by mmb on October 17, 2004, at 4:35:03

In reply to Re: L-glutamine ..forgot to add,,,JLx..mmb, posted by tealady on October 16, 2004, at 22:21:40

> >
> > That's good that you are taking capsules and liquid form ..and even dissolving them first to ensure absorption. (I'll have to stop being lazy <g>)
> >
> > I guess some people just tablet form and not on empty stomach for the amino acids..and either waste them or need huge doses comparatively for any effect.
> > From what I understand people who continue to feel great on l-glutamine are usually fairly active..even athletic.
> >
> > so Q1. Re you fairly active?

Well, I cycle for 3 KM every day and that's about it. What really depletes my storage of nutrients is stress and I often feel like I played basketball for 6 hours after coming from work. That's where glutamine helped - fueled my brain with energy so that I am not tired anymore and somehow it calms me down (just like JL said probably it converts to GABA).
> >
> > Q2. Are you fairly young under 35? This may be important as there is some thought that the higher levels of estrogen , progesterobne protect from glutamate toxicity

Yes, I am under 35 (32). However after my last post isn't dosage of 2000 mg ridicolous to talk about toxicity even in a long term when you know that the body stores 100.000 mg of it?
> >
> >
> > Q3. good cortisol levels? not too low at least!
> > (see abstract at bottom)

Cortisol was my main problem when stressed. It can have devastating power on your body during long periods of stress and again because L-glutamine calms me down I guess my cortisol levels are lower.

> > A deficiency in glutamine synthetase might be responsible for the high extracellular concentrations of glutamate that are indicted as a likely trigger of epileptic seizures, the researchers noted.
> >

Now, who can explain this? I read that L-glutamine is helpful with epilepsy but here I am confused (why don't these MDs and Phds write in understandable language)
> Q4. Great thyroid hormone levels? (that's the T3 in the article above)

Last time I checked my thyroid hormone levels were normal (actually I was feeling so bad that I tried to find explenation in my symptoms but turned out I was healthy - did not do amino acid test however). So nothing new there.

I just would like to mention another interesting thing - I also tried GABA (I told you I tried everything) and I felt terrible. Actually, the first hour I feel wonderful but then the anxiety attacks kept coming. After trying it for 2 days with minimal dosage (100 mg) I gave up. I still have GABA but maybe in the future when I feel confident I will try it again.

Also, do not forget diet. My diet is very poor in: milk, eggs, meat. Now, after trying amino acids I saw that they even further calm me down and get me more alert. After comparing my workload and diet that I take I understood that I do not get enough nutrients in to my body. I do not believe in perfect healthy diet. There is no such thing when you are stressed. I definitely needed to supplement and nothing had more impact than amino acids (together with minerals). BTW, this capsule of amino acid mix contains 822 mg of Glutamic acid together with all other amino acids.
> >
> >
> > Jan
> >
> > -------------------------------
> > Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> > Ved HS, Gustow E, Pieringer RA
> > Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
> > The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC.
> >
> >




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