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Re: L-glutamine helped me with anxiety! » mmb

Posted by JLx on October 16, 2004, at 20:25:47

In reply to Re: L-glutamine helped me with anxiety!, posted by mmb on October 16, 2004, at 17:33:19

> Hi,
> here is one of dozens of articles about health benefits of L-glutamine:

I know there's lots of info about the benefits of glutamine. That's why I was taking it. When I reacted badly to it is when I started looking for a possible explanation. THis site notes that "glutamine is a substrate for the production of both excitatory and inhibitory neurotransmitters (glutamate and GABA)."
It sounds like in your experience, what was produced was GABA, in mine glutamate.

> Also, there is a book called "L-glutamine - The ultimate nutrient" By Judy Shabert, MD, RD and Nancy Ehrlich. You can find literally hundreds of links to health benefits of l-glutamine and to be honest the one that you provided is the first one that I read that mentions glutamine as possible problematic supplement (thanx for that always like to hear other view). Just notice that in this article it always says "high doses" which are never mentioned (how much is high dosage?).

1-2 grams?

"In order to maximize clearance of synaptic glutamate, it will also be necessary to avoid use of the nutritional supplement glutamine. The health food industry has promoted glutamine use for decades, often in multi-gram quantities. A 1994 book touts glutamine "to strengthen the immune system, improve muscle mass, and heal the digestive tract" (43). It is true that many studies do show benefits form short-term, often high dose, glutamine use. It must be remembered, however, that glutamine easily passes the blood-brain barrier and enters the astrocytes and neurons, where it can be converted to glutamate. And the excitotoxic damage from excess glutamate may take a lifetime to develop to the point of expressing itself as a stroke, Alzheimer’s or Parkinson's disease, etc. But high dose glutamine can cause excitotoxic problems even in the short term. ... glutamine supplementation should probably not exceed 1-2 grams daily, if it is used at all."





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