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Chemist, a question for you please.....

Posted by WAKI on July 28, 2004, at 12:40:57

In reply to Re: Chemist... Missed you!!! » simus, posted by chemist on July 27, 2004, at 8:25:11

Hello Chemist,

I need your opinion on this subject thread. I will copy it here for you to understand the question and answer given.

The question to you will be to evaluate why Strattera could make someone depressed even though it works with the NE.

Heres the original question from another post:

An 8 week trial of Strattera for ADHD induced melancholic symptoms which abated upon withdrawal of it. What could possible be the mechanism for this? She has dysthymia, ADHD, anxiety/social phobia, and Fibromyalgia with atypical features. Thoughts/conjectures?

Another person replied with this answer:

One of the few clues we had was that NE reuptake inhibitors were THERAPEUTIC for melancholic depression, so it's ironic that while non-selective NE reuptake inhibitors (output hardly seems to be amenable to conjecture yet.TCA's) have real efficacy for this disorder, selective ones like reboxetine and Strattera can worsen or induce such symptoms.


Chemist,
You explain things really well. Could you take a shot at this original question please?

Thanks!


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poster:WAKI thread:370809
URL: http://www.dr-bob.org/babble/alter/20040718/msgs/371657.html